Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension

An accumulating body of evidence incriminates Rho kinase (ROCK) in the pathogenesis of pulmonary hypertension (PH). The therapeutic efficacy of azaindole-1, a novel highly selective and orally active ROCK inhibitor, has not yet been investigated in PH. This study aimed to investigate the effects of...

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Veröffentlicht in:	The European respiratory journal 2010-10, Vol.36 (4), p.808-818
Hauptverfasser:	DAHAL, B. K, KOSANOVIC, D, GRIMMINGER, F, SEEGER, W, SCHERMULY, R. T, PAMARTHI, P. K, SYDYKOV, A, LAI, Y.-J, KAST, R, SCHIROK, H, STASCH, J.-P, GHOFRANI, H. A, WEISSMANN, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azabicyclo Compounds - therapeutic use Biological and medical sciences Cell Proliferation Disease Models, Animal Enzyme Inhibitors - pharmacology Hemodynamics Hypertension, Pulmonary - drug therapy Indoles - therapeutic use Lung - pathology Male Medical sciences Mice Pneumology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rats Rats, Sprague-Dawley rho-Associated Kinases - antagonists & inhibitors Telemetry - methods Tetrazolium Salts - pharmacology Thiazoles - pharmacology Thymidine - chemistry Treatment Outcome
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