Molybdenum hydroxylase super family shows circadian activity fluctuation in mice liver: emphasis on aldehyde hydroxylase and xanthine oxidase
Non-CYP oxidase enzymes are important system in biotransformation of drugs and environmental pollutants. Molybdenum containing oxidase enzymes such as aldehyde oxidase and xanthine oxidase are constitutive tissue enzymes that metabolize several drug moieties. Herein, we evaluated the circadian rhyth...
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| Veröffentlicht in: | Pakistan journal of pharmaceutical sciences 2010-10, Vol.23 (4), p.359-362 |
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| creator | Abbasi, Fahad Ahmed Al Sieni, Abdulbasit Ibraheem Al |
| description | Non-CYP oxidase enzymes are important system in biotransformation of drugs and environmental pollutants. Molybdenum containing oxidase enzymes such as aldehyde oxidase and xanthine oxidase are constitutive tissue enzymes that metabolize several drug moieties. Herein, we evaluated the circadian rhythm of these two enzymes in mice liver using different substrate/oxygen donor couples. Aldehyde oxidase showed typical rhythmic fluctuation with peak activity at night cycle and minimum activity at light cycle using pthalazine/ferricyanide and 3-methylisoquinoline/ferricyanide substrates. On the other hand, xanthine oxidase showed interrupted diurnal rhythm, however peak and minimum enzyme activities were similar to aldehyde oxidase circadian rhythm. In conclusion, diurnal rhythm of both molybdenum hydroxylase enzymes was confirmed and validated in mice liver tissue that might provide further insights in the experimental evaluation of phase-I pharmacokinetics for new drugs. |
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Molybdenum containing oxidase enzymes such as aldehyde oxidase and xanthine oxidase are constitutive tissue enzymes that metabolize several drug moieties. Herein, we evaluated the circadian rhythm of these two enzymes in mice liver using different substrate/oxygen donor couples. Aldehyde oxidase showed typical rhythmic fluctuation with peak activity at night cycle and minimum activity at light cycle using pthalazine/ferricyanide and 3-methylisoquinoline/ferricyanide substrates. On the other hand, xanthine oxidase showed interrupted diurnal rhythm, however peak and minimum enzyme activities were similar to aldehyde oxidase circadian rhythm. In conclusion, diurnal rhythm of both molybdenum hydroxylase enzymes was confirmed and validated in mice liver tissue that might provide further insights in the experimental evaluation of phase-I pharmacokinetics for new drugs.</description><identifier>ISSN: 1011-601X</identifier><identifier>PMID: 20884446</identifier><language>eng</language><publisher>Pakistan: Pakistan Journal of Pharmaceutical Sciences</publisher><subject>Aldehyde Oxidase - metabolism ; Aldehydes ; Animals ; Circadian Rhythm - physiology ; Environmental Pollutants - metabolism ; Enzymes ; Ferricyanides - metabolism ; Iron compounds ; Liver ; Liver - enzymology ; Male ; Mice ; Mixed Function Oxygenases - metabolism ; Molybdenum ; Molybdenum compounds ; Oxidases ; Oxidation-Reduction ; Oxygen Consumption - physiology ; Pharmaceutical Preparations - metabolism ; Phthalazines - metabolism ; Purines ; Xanthine Oxidase - metabolism</subject><ispartof>Pakistan journal of pharmaceutical sciences, 2010-10, Vol.23 (4), p.359-362</ispartof><rights>COPYRIGHT 2010 Pakistan Journal of Pharmaceutical Sciences</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20884446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abbasi, Fahad Ahmed Al</creatorcontrib><creatorcontrib>Sieni, Abdulbasit Ibraheem Al</creatorcontrib><title>Molybdenum hydroxylase super family shows circadian activity fluctuation in mice liver: emphasis on aldehyde hydroxylase and xanthine oxidase</title><title>Pakistan journal of pharmaceutical sciences</title><addtitle>Pak J Pharm Sci</addtitle><description>Non-CYP oxidase enzymes are important system in biotransformation of drugs and environmental pollutants. Molybdenum containing oxidase enzymes such as aldehyde oxidase and xanthine oxidase are constitutive tissue enzymes that metabolize several drug moieties. Herein, we evaluated the circadian rhythm of these two enzymes in mice liver using different substrate/oxygen donor couples. Aldehyde oxidase showed typical rhythmic fluctuation with peak activity at night cycle and minimum activity at light cycle using pthalazine/ferricyanide and 3-methylisoquinoline/ferricyanide substrates. On the other hand, xanthine oxidase showed interrupted diurnal rhythm, however peak and minimum enzyme activities were similar to aldehyde oxidase circadian rhythm. In conclusion, diurnal rhythm of both molybdenum hydroxylase enzymes was confirmed and validated in mice liver tissue that might provide further insights in the experimental evaluation of phase-I pharmacokinetics for new drugs.</description><subject>Aldehyde Oxidase - metabolism</subject><subject>Aldehydes</subject><subject>Animals</subject><subject>Circadian Rhythm - physiology</subject><subject>Environmental Pollutants - metabolism</subject><subject>Enzymes</subject><subject>Ferricyanides - metabolism</subject><subject>Iron compounds</subject><subject>Liver</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Mice</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>Molybdenum</subject><subject>Molybdenum compounds</subject><subject>Oxidases</subject><subject>Oxidation-Reduction</subject><subject>Oxygen Consumption - physiology</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>Phthalazines - metabolism</subject><subject>Purines</subject><subject>Xanthine Oxidase - metabolism</subject><issn>1011-601X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1OwzAMx3sAsTF4BRSJA6ehpM3Shts08SUNcQGJW-Um7haUJqNpYX0I3pmgjcMk5IMt--e_LfsoGTPK2FRQ9jZKTkN4p1RwKeVJMkppUXDOxTj5fvJ2qDS6viHrQbd-O1gISEK_wZbU0Bg7kLD2X4Eo0yrQBhwB1ZlP0w2ktr3qeuiMd8Q40hiFxJpPbG8INps1BBNILIHVGMXxYAI4TbbgurVxSPzW6Jg8S45rsAHP936SvN7dviwepsvn-8fFfDldMZl2U5EXWaohRWAZy2e0qnKpRcVpVVR1xWvNYigZZirTGZvlWZ5KRSkqLXPFlc4mydVOd9P6jx5DVzYmKLQWHPo-lPlMCJHyYhbJyx25AoulcbXvWlC_dDlPJS9kIXgeqet_qGga4028w9rE_EHDxX6BvmpQl5vWNNAO5d9jsh-GRIu-</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Abbasi, Fahad Ahmed Al</creator><creator>Sieni, Abdulbasit Ibraheem Al</creator><general>Pakistan Journal of Pharmaceutical Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Molybdenum hydroxylase super family shows circadian activity fluctuation in mice liver: emphasis on aldehyde hydroxylase and xanthine oxidase</title><author>Abbasi, Fahad Ahmed Al ; Sieni, Abdulbasit Ibraheem Al</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g192t-67832da2ea131750bb79d6b40b8bfb4fd140b91e3c3d31573729c00ecd97c4cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aldehyde Oxidase - metabolism</topic><topic>Aldehydes</topic><topic>Animals</topic><topic>Circadian Rhythm - physiology</topic><topic>Environmental Pollutants - metabolism</topic><topic>Enzymes</topic><topic>Ferricyanides - metabolism</topic><topic>Iron compounds</topic><topic>Liver</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Mice</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>Molybdenum</topic><topic>Molybdenum compounds</topic><topic>Oxidases</topic><topic>Oxidation-Reduction</topic><topic>Oxygen Consumption - physiology</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>Phthalazines - metabolism</topic><topic>Purines</topic><topic>Xanthine Oxidase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbasi, Fahad Ahmed Al</creatorcontrib><creatorcontrib>Sieni, Abdulbasit Ibraheem Al</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pakistan journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbasi, Fahad Ahmed Al</au><au>Sieni, Abdulbasit Ibraheem Al</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molybdenum hydroxylase super family shows circadian activity fluctuation in mice liver: emphasis on aldehyde hydroxylase and xanthine oxidase</atitle><jtitle>Pakistan journal of pharmaceutical sciences</jtitle><addtitle>Pak J Pharm Sci</addtitle><date>2010-10</date><risdate>2010</risdate><volume>23</volume><issue>4</issue><spage>359</spage><epage>362</epage><pages>359-362</pages><issn>1011-601X</issn><abstract>Non-CYP oxidase enzymes are important system in biotransformation of drugs and environmental pollutants. Molybdenum containing oxidase enzymes such as aldehyde oxidase and xanthine oxidase are constitutive tissue enzymes that metabolize several drug moieties. Herein, we evaluated the circadian rhythm of these two enzymes in mice liver using different substrate/oxygen donor couples. Aldehyde oxidase showed typical rhythmic fluctuation with peak activity at night cycle and minimum activity at light cycle using pthalazine/ferricyanide and 3-methylisoquinoline/ferricyanide substrates. On the other hand, xanthine oxidase showed interrupted diurnal rhythm, however peak and minimum enzyme activities were similar to aldehyde oxidase circadian rhythm. In conclusion, diurnal rhythm of both molybdenum hydroxylase enzymes was confirmed and validated in mice liver tissue that might provide further insights in the experimental evaluation of phase-I pharmacokinetics for new drugs.</abstract><cop>Pakistan</cop><pub>Pakistan Journal of Pharmaceutical Sciences</pub><pmid>20884446</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Pakistan journal of pharmaceutical sciences, 2010-10, Vol.23 (4), p.359-362 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aldehyde Oxidase - metabolism Aldehydes Animals Circadian Rhythm - physiology Environmental Pollutants - metabolism Enzymes Ferricyanides - metabolism Iron compounds Liver Liver - enzymology Male Mice Mixed Function Oxygenases - metabolism Molybdenum Molybdenum compounds Oxidases Oxidation-Reduction Oxygen Consumption - physiology Pharmaceutical Preparations - metabolism Phthalazines - metabolism Purines Xanthine Oxidase - metabolism |
| title | Molybdenum hydroxylase super family shows circadian activity fluctuation in mice liver: emphasis on aldehyde hydroxylase and xanthine oxidase |
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