TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

Abstract In diet-induced obesity, hypothalamic inflammation is triggered as an outcome of prolonged exposure to dietary fats. Toll-like receptor 4 (TLR4) activation plays a central role in this process, inducing endoplasmic reticulum stress and activating inflammatory cytokine gene transcription. Al...

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Veröffentlicht in:	Neuroscience 2010-11, Vol.170 (4), p.1035-1044
Hauptverfasser:	Denis, R.G, Arruda, A.P, Romanatto, T, Milanski, M, Coope, A, Solon, C, Razolli, D.S, Velloso, L.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences cytokine diabetes Endoplasmic Reticulum - physiology food intake Fundamental and applied biological sciences. Psychology Hypothalamus - drug effects Hypothalamus - metabolism Hypothalamus - pathology Inflammation - pathology insulin leptin Lipopolysaccharides - pharmacology Male Medical sciences Membrane Proteins - antagonists & inhibitors Membrane Proteins - biosynthesis Membrane Proteins - genetics Metabolic diseases Mice Mice, Knockout Neurology Obesity Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - genetics Rats Rats, Wistar Receptors, Tumor Necrosis Factor, Type I - genetics Toll-Like Receptor 4 - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology Unfolded Protein Response Vertebrates: nervous system and sense organs
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