Effect on Virulence and Pathogenicity of H5N1 Influenza A Virus through Truncations of NS1 eIF4GI Binding Domain

To study the effect of NS1 eIF4GI binding domain on virulence and pathogenicity of H5N1 influenza A virus, 5 recombinant H5N1 viruses encoding eIF4GI binding domain—truncated NS1 proteins and parental NS1 (NS1-wt) were generated by an 8-plasmid—based reverse genetics system. The results indicated th...

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Veröffentlicht in:	The Journal of infectious diseases 2010-11, Vol.202 (9), p.1338-1346
Hauptverfasser:	Zhou, Hongbo, Zhu, Jiping, Tu, Jiagang, Zou, Wei, Hu, Yong, Yu, Zhengjun, Yin, Wensi, Li, Yongtao, Zhang, Anding, Wu, Yurong, Yu, Ziniu, Chen, Huanchun, Jin, Meilin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Chick Embryo Chickens Dogs Eukaryotic Initiation Factor-4G - metabolism Female Fundamental and applied biological sciences. Psychology H5N1 subtype influenza A virus Infections Infectious diseases Influenza A virus Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - pathogenicity Influenza in Birds - pathology Influenza in Birds - virology Interferons - antagonists & inhibitors Interferons - immunology Medical sciences Messenger RNA Mice Mice, Inbred BALB C Microbiology Orthomyxoviridae Orthomyxoviridae Infections - pathology Orthomyxoviridae Infections - virology Protein Binding Sequence Deletion Transcriptional regulatory elements Vero cells Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virulence Virulence Factors - genetics Virulence Factors - metabolism Virus Replication Viruses
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