A Peptidomics Strategy for Discovering Endogenous Bioactive Peptides

Peptide hormones and neuropeptides constitute an important class of naturally occurring peptides that are generated from precursor proteins by limited proteolytic processing. An important but unaddressed issue in peptidomics is to pin down novel bioactive peptides in a bulk of peptide sequences prov...

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Veröffentlicht in:	Journal of proteome research 2010-10, Vol.9 (10), p.5047-5052
Hauptverfasser:	Sasaki, Kazuki, Takahashi, Noriyuki, Satoh, Mitsuo, Yamasaki, Motoo, Minamino, Naoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Aequorin - genetics Aequorin - metabolism Amino Acid Sequence Animals Apoproteins - genetics Apoproteins - metabolism Cell Line, Tumor Chromatography, Liquid Humans Mice Mice, Transgenic Molecular Sequence Data Neuropeptides - genetics Neuropeptides - metabolism Organ Specificity Peptides - genetics Peptides - metabolism Proteomics - methods Rats Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Homology, Amino Acid Tandem Mass Spectrometry
Online-Zugang:	Volltext
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