Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig
In passively sensitized anesthetized guinea pigs, intravenous infusion of low doses of antigen ovalbumin induced a marked increased responsivity of the airways to intravenous injection of leukotriene C 4. Sustained infusion of racemic salbutamol intensified responses to leukotriene C 4 both before a...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1993-04, Vol.91 (4), p.909-916 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | Hoshiko, Ken-ichiro Kristersson, Anne Morley, John |
| description | In passively sensitized anesthetized guinea pigs, intravenous infusion of low doses of antigen ovalbumin induced a marked increased responsivity of the airways to intravenous injection of leukotriene C
4. Sustained infusion of racemic salbutamol intensified responses to leukotriene C
4 both before and after infusion of ovalbumin. Hyperreactivity as a result of infusion of ovalbumin was inhibited by intraduodenal injection of either hydrocortisone or ketotifen at doses that did not diminish responses to leukotriene C
4 in animals not exposed to antigen. Ketotifen, but not hydrocortisone, inhibited the enhanced hyperreactivity associated with infusion of racemic salbutamol. |
| doi_str_mv | 10.1016/0091-6749(93)90349-K |
| format | Article |
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4. Sustained infusion of racemic salbutamol intensified responses to leukotriene C
4 both before and after infusion of ovalbumin. Hyperreactivity as a result of infusion of ovalbumin was inhibited by intraduodenal injection of either hydrocortisone or ketotifen at doses that did not diminish responses to leukotriene C
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4. Sustained infusion of racemic salbutamol intensified responses to leukotriene C
4 both before and after infusion of ovalbumin. Hyperreactivity as a result of infusion of ovalbumin was inhibited by intraduodenal injection of either hydrocortisone or ketotifen at doses that did not diminish responses to leukotriene C
4 in animals not exposed to antigen. Ketotifen, but not hydrocortisone, inhibited the enhanced hyperreactivity associated with infusion of racemic salbutamol.</description><subject>Albuterol - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity - prevention & control</subject><subject>bronchospasm</subject><subject>Dose-Response Relationship, Drug</subject><subject>Guinea Pigs</subject><subject>hydrocortisone</subject><subject>Hydrocortisone - pharmacology</subject><subject>hyperreactivity</subject><subject>Ketotifen</subject><subject>Ketotifen - pharmacology</subject><subject>leukotriene C 4</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Ovalbumin - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiratory system</subject><subject>salbutamol</subject><subject>SRS-A - pharmacology</subject><subject>Stereoisomerism</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1EVZbCPwDJB4TgELDXsRNfkFDFR7WVuMDZmjiT3anysdhOIf--Xna1R3qyxvO8r2beYeyVFB-kkOajEFYWpirtO6veW6FKW2yesJUUtipMvdZP2eqMPGPPY7wTuVa1vWSXdVkpU4sVu9tgmhJ1OHIad9RQihz_gsfQQKJp5FPHoe8xbMlzoPAHFr5b9hgCgk90T2nhzcJDVgyZiNA3c4Jh6rMdTzvk25lGBL6n7Qt20UEf8eXpvWK_vn75ef29uP3x7eb6823hS6NS0SnfaNMo1a1rVVet9HWLaHQFVuXppbbae28k1EaVa4GAupPo2yb_a7RaXbG3R999mH7PGJMbKHrsexhxmqOrtDFSK_UoKE21VkbJDJZH0IcpxoCd2wcaICxOCne4hTsE7Q5BO6vcv1u4TZa9PvnPzYDtWXQKP_ffnPoQPfRdgNFTPGNllZetDvt8OmKYQ7snDC56wtFjSwF9cu1E_5_jAUnCpzk</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Hoshiko, Ken-ichiro</creator><creator>Kristersson, Anne</creator><creator>Morley, John</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig</title><author>Hoshiko, Ken-ichiro ; Kristersson, Anne ; Morley, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-f3cb56b33f28387d1c8dee657a939381595ccc61a863420eae5f1ecdb95c5e953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Albuterol - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchial Hyperreactivity - prevention & control</topic><topic>bronchospasm</topic><topic>Dose-Response Relationship, Drug</topic><topic>Guinea Pigs</topic><topic>hydrocortisone</topic><topic>Hydrocortisone - pharmacology</topic><topic>hyperreactivity</topic><topic>Ketotifen</topic><topic>Ketotifen - pharmacology</topic><topic>leukotriene C 4</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Ovalbumin - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiratory system</topic><topic>salbutamol</topic><topic>SRS-A - pharmacology</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoshiko, Ken-ichiro</creatorcontrib><creatorcontrib>Kristersson, Anne</creatorcontrib><creatorcontrib>Morley, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of allergy and clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoshiko, Ken-ichiro</au><au>Kristersson, Anne</au><au>Morley, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>91</volume><issue>4</issue><spage>909</spage><epage>916</epage><pages>909-916</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>In passively sensitized anesthetized guinea pigs, intravenous infusion of low doses of antigen ovalbumin induced a marked increased responsivity of the airways to intravenous injection of leukotriene C
4. Sustained infusion of racemic salbutamol intensified responses to leukotriene C
4 both before and after infusion of ovalbumin. Hyperreactivity as a result of infusion of ovalbumin was inhibited by intraduodenal injection of either hydrocortisone or ketotifen at doses that did not diminish responses to leukotriene C
4 in animals not exposed to antigen. Ketotifen, but not hydrocortisone, inhibited the enhanced hyperreactivity associated with infusion of racemic salbutamol.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>8473680</pmid><doi>10.1016/0091-6749(93)90349-K</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0091-6749 |
| ispartof | Journal of allergy and clinical immunology, 1993-04, Vol.91 (4), p.909-916 |
| issn | 0091-6749 1097-6825 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Albuterol - pharmacology Animals Biological and medical sciences Bronchial Hyperreactivity - prevention & control bronchospasm Dose-Response Relationship, Drug Guinea Pigs hydrocortisone Hydrocortisone - pharmacology hyperreactivity Ketotifen Ketotifen - pharmacology leukotriene C 4 Male Medical sciences Ovalbumin - immunology Pharmacology. Drug treatments Respiratory system salbutamol SRS-A - pharmacology Stereoisomerism |
| title | Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig |
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