Conformational influence of the ribose 2'-hydroxyl group: Crystal structures of DNA-RNA chimeric duplexes

We have crystallized three double-helical DNA-RNA chimeric duplexes and determined their structures by X-ray crystallography at resolutions between 2 and 2.25 A. The two self-complementary duplexes [r(G)d(CGTATACGC)]2 and [d(GCGT)r(A)d(TACGC)]2, as well as the Okazaki fragment d(GGGTATACGC).r(GCG)d(...

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Veröffentlicht in:	Biochemistry (Easton) 1993-04, Vol.32 (13), p.3221-3237
Hauptverfasser:	Egli, Martin, Usman, Nassim, Rich, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Base Sequence Biological and medical sciences Crystallography Deoxyribose - chemistry DNA - chemistry Dna, deoxyribonucleoproteins Exobiology Fundamental and applied biological sciences. Psychology Hydrogen Bonding Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Nucleic acids Ribose - chemistry RNA - chemistry Space life sciences X-Rays
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