Investigation of two new [ 99mTc]Tc-HEDP preparations that can be expected to give a better lesion-to-normal-bone uptake ratio when used as bone scanning agents
Two new potential bone scanning agents have been prepared and characterized. One of the agents, Tc(Sn,pH 12)-HEDP, is prepared at pH 12 (and subsequently neutralized). The other agent, Tc(Fe)-HEDP, is prepared by reducing [ 99mTc]TcO 4 − by a mixture of Fe(II) and Sn(II). From ion exchange chromatog...
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| Veröffentlicht in: | Nuclear medicine and biology 1993, Vol.20 (1), p.23-29 |
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| creator | de Ligny, C.L. Gelsema, W.J. Hoevelaken, T.P.M. Schuring, J. |
| description | Two new potential bone scanning agents have been prepared and characterized. One of the agents, Tc(Sn,pH 12)-HEDP, is prepared at pH 12 (and subsequently neutralized). The other agent, Tc(Fe)-HEDP, is prepared by reducing [
99mTc]TcO
4
− by a mixture of Fe(II) and Sn(II).
From ion exchange chromatography on Aminex A-28 it appeared that the proportion of early eluting components of the two new agents is larger than that of the usual agent, Tc(Sn,pH 7.4)-HEDP. The stabilities on storage, and in serum, of the three agents appeared to be equally good. The adsorption on tri-calciumphosphate of Tc(Fe)-HEDP and Tc(Sn,pH 7.4)-HEDP was determined at several values of concentrations of Sn(II) and HEDP. Further, the influence of the pH (1–12) during reduction of [
99mTc]TcO
4
− by Sn(II) on the adsorption of the agent on tri-calciumphosphate (at a fixed pH of 7.4) was investigated. It appeared that the adsorption of Tc(Sn,pH 12)-HEDP and Tc(Fe)-HEDP is less than that of Tc(Sn,pH 7.4)-HEDP.
It is argued that this result points to a better efficiency in lesion detection of the two new agents, compared to the usual one. |
| doi_str_mv | 10.1016/0969-8051(93)90133-F |
| format | Article |
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99mTc]TcO
4
− by a mixture of Fe(II) and Sn(II).
From ion exchange chromatography on Aminex A-28 it appeared that the proportion of early eluting components of the two new agents is larger than that of the usual agent, Tc(Sn,pH 7.4)-HEDP. The stabilities on storage, and in serum, of the three agents appeared to be equally good. The adsorption on tri-calciumphosphate of Tc(Fe)-HEDP and Tc(Sn,pH 7.4)-HEDP was determined at several values of concentrations of Sn(II) and HEDP. Further, the influence of the pH (1–12) during reduction of [
99mTc]TcO
4
− by Sn(II) on the adsorption of the agent on tri-calciumphosphate (at a fixed pH of 7.4) was investigated. It appeared that the adsorption of Tc(Sn,pH 12)-HEDP and Tc(Fe)-HEDP is less than that of Tc(Sn,pH 7.4)-HEDP.
It is argued that this result points to a better efficiency in lesion detection of the two new agents, compared to the usual one.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/0969-8051(93)90133-F</identifier><identifier>PMID: 8461877</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adsorption ; Bone and Bones - diagnostic imaging ; Calcium Phosphates - chemistry ; Etidronic Acid - chemistry ; Etidronic Acid - pharmacokinetics ; Humans ; Organotechnetium Compounds - chemistry ; Organotechnetium Compounds - pharmacokinetics ; Radionuclide Imaging</subject><ispartof>Nuclear medicine and biology, 1993, Vol.20 (1), p.23-29</ispartof><rights>1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-5ab302ace0658403f0131c80b7bd17a7bfbbe0919bcf94e1af8aba0df5d8e9f83</citedby><cites>FETCH-LOGICAL-c272t-5ab302ace0658403f0131c80b7bd17a7bfbbe0919bcf94e1af8aba0df5d8e9f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/096980519390133F$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8461877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Ligny, C.L.</creatorcontrib><creatorcontrib>Gelsema, W.J.</creatorcontrib><creatorcontrib>Hoevelaken, T.P.M.</creatorcontrib><creatorcontrib>Schuring, J.</creatorcontrib><title>Investigation of two new [ 99mTc]Tc-HEDP preparations that can be expected to give a better lesion-to-normal-bone uptake ratio when used as bone scanning agents</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>Two new potential bone scanning agents have been prepared and characterized. One of the agents, Tc(Sn,pH 12)-HEDP, is prepared at pH 12 (and subsequently neutralized). The other agent, Tc(Fe)-HEDP, is prepared by reducing [
99mTc]TcO
4
− by a mixture of Fe(II) and Sn(II).
From ion exchange chromatography on Aminex A-28 it appeared that the proportion of early eluting components of the two new agents is larger than that of the usual agent, Tc(Sn,pH 7.4)-HEDP. The stabilities on storage, and in serum, of the three agents appeared to be equally good. The adsorption on tri-calciumphosphate of Tc(Fe)-HEDP and Tc(Sn,pH 7.4)-HEDP was determined at several values of concentrations of Sn(II) and HEDP. Further, the influence of the pH (1–12) during reduction of [
99mTc]TcO
4
− by Sn(II) on the adsorption of the agent on tri-calciumphosphate (at a fixed pH of 7.4) was investigated. It appeared that the adsorption of Tc(Sn,pH 12)-HEDP and Tc(Fe)-HEDP is less than that of Tc(Sn,pH 7.4)-HEDP.
It is argued that this result points to a better efficiency in lesion detection of the two new agents, compared to the usual one.</description><subject>Adsorption</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Calcium Phosphates - chemistry</subject><subject>Etidronic Acid - chemistry</subject><subject>Etidronic Acid - pharmacokinetics</subject><subject>Humans</subject><subject>Organotechnetium Compounds - chemistry</subject><subject>Organotechnetium Compounds - pharmacokinetics</subject><subject>Radionuclide Imaging</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEURC0ECpPAH4B0V4gsDPb00xskFDIkUiRYDCuELNt9e2Lotju2ewb-hk_F81CWrCy5TpXlKkJecfaOM16_Z6IWtGUVfyuKS8F4UdDVE7LgbbOkoublU7J4RJ6T8xh_smwrOTsjZ21ZZ65ZkL-3bosx2Y1K1jvwPaSdB4c7-A5CjGvzY23ozfWnrzAFnFQ4YBHSvUpglAONgL8nNAk7SB42doug8m1KGGDAmGmaPHU-jGqg2juEeUrqF8IhCnb36GCO2a0iHOSYY511G1AbdCm-IM96NUR8eTovyLfV9frqht59-Xx79fGOmmWzTLRSumBLZZDVVVuyos99cNMy3eiON6rRvdbIBBfa9KJErvpWacW6vupaFH1bXJA3x9wp-Ic5VyJHGw0Og3Lo5yibqq5Z09QZLI-gCT7GgL2cgh1V-CM5k_th5L51uW9dikIehpGrbHt9yp_1iN2j6bRE1j8cdcyf3FoMMhqLzmBnQ65Xdt7-_4F_MGuf7A</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>de Ligny, C.L.</creator><creator>Gelsema, W.J.</creator><creator>Hoevelaken, T.P.M.</creator><creator>Schuring, J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Investigation of two new [ 99mTc]Tc-HEDP preparations that can be expected to give a better lesion-to-normal-bone uptake ratio when used as bone scanning agents</title><author>de Ligny, C.L. ; Gelsema, W.J. ; Hoevelaken, T.P.M. ; Schuring, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-5ab302ace0658403f0131c80b7bd17a7bfbbe0919bcf94e1af8aba0df5d8e9f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adsorption</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Calcium Phosphates - chemistry</topic><topic>Etidronic Acid - chemistry</topic><topic>Etidronic Acid - pharmacokinetics</topic><topic>Humans</topic><topic>Organotechnetium Compounds - chemistry</topic><topic>Organotechnetium Compounds - pharmacokinetics</topic><topic>Radionuclide Imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Ligny, C.L.</creatorcontrib><creatorcontrib>Gelsema, W.J.</creatorcontrib><creatorcontrib>Hoevelaken, T.P.M.</creatorcontrib><creatorcontrib>Schuring, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Ligny, C.L.</au><au>Gelsema, W.J.</au><au>Hoevelaken, T.P.M.</au><au>Schuring, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigation of two new [ 99mTc]Tc-HEDP preparations that can be expected to give a better lesion-to-normal-bone uptake ratio when used as bone scanning agents</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1993</date><risdate>1993</risdate><volume>20</volume><issue>1</issue><spage>23</spage><epage>29</epage><pages>23-29</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>Two new potential bone scanning agents have been prepared and characterized. One of the agents, Tc(Sn,pH 12)-HEDP, is prepared at pH 12 (and subsequently neutralized). The other agent, Tc(Fe)-HEDP, is prepared by reducing [
99mTc]TcO
4
− by a mixture of Fe(II) and Sn(II).
From ion exchange chromatography on Aminex A-28 it appeared that the proportion of early eluting components of the two new agents is larger than that of the usual agent, Tc(Sn,pH 7.4)-HEDP. The stabilities on storage, and in serum, of the three agents appeared to be equally good. The adsorption on tri-calciumphosphate of Tc(Fe)-HEDP and Tc(Sn,pH 7.4)-HEDP was determined at several values of concentrations of Sn(II) and HEDP. Further, the influence of the pH (1–12) during reduction of [
99mTc]TcO
4
− by Sn(II) on the adsorption of the agent on tri-calciumphosphate (at a fixed pH of 7.4) was investigated. It appeared that the adsorption of Tc(Sn,pH 12)-HEDP and Tc(Fe)-HEDP is less than that of Tc(Sn,pH 7.4)-HEDP.
It is argued that this result points to a better efficiency in lesion detection of the two new agents, compared to the usual one.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>8461877</pmid><doi>10.1016/0969-8051(93)90133-F</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Nuclear medicine and biology, 1993, Vol.20 (1), p.23-29 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_75660776 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adsorption Bone and Bones - diagnostic imaging Calcium Phosphates - chemistry Etidronic Acid - chemistry Etidronic Acid - pharmacokinetics Humans Organotechnetium Compounds - chemistry Organotechnetium Compounds - pharmacokinetics Radionuclide Imaging |
| title | Investigation of two new [ 99mTc]Tc-HEDP preparations that can be expected to give a better lesion-to-normal-bone uptake ratio when used as bone scanning agents |
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