Synthesis and pharmacological evaluation of hexahydrofluorenamines as noncompetitive antagonists at the N-methyl-D-aspartate receptor

The noncompetitive (PCP) site of the N-methyl-D-aspartate (NMDA) receptor complex has been implicated in a number of pathologies, including the etiology of ischemic stroke. Recent testing has shown that cis-1,2,3,4,9,9a-hexahydro-N-methyl-4aH-fluoren-4a-amine (1), a rigid analog of PCP, is a potent...

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Veröffentlicht in:	Journal of medicinal chemistry 1993-03, Vol.36 (6), p.654-670
Hauptverfasser:	Hays, Sheryl J, Novak, Perry M, Ortwine, Daniel F, Bigge, Christopher F, Colbry, Norman L, Johnson, Graham, Lescosky, Leonard J, Malone, Thomas C, Michael, Andre
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Aliphatic, non-condensed and condensed benzenic, and alicyclic compounds Animals Binding Sites Chemistry Condensed matter: structure, mechanical and thermal properties Exact sciences and technology Fluorenes - chemical synthesis Fluorenes - chemistry Fluorenes - pharmacology Magnetic Resonance Spectroscopy Male Mice Models, Molecular Organic chemistry Organic compounds Phencyclidine - metabolism Physics Preparations and properties Rats Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Seizures - prevention & control Stereoisomerism Structure of solids and liquids crystallography Structure of specific crystalline solids Structure-Activity Relationship
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