Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia
Changes in the nuclear magnetic resonance (NMR) parameters of spin-lattice relaxation ( T 1), spin-spin relaxation ( T 2), proton density (ϱ), and water diffusion ( D NMR) were measured over time together with the histopathological status in three regions of rat brain cortex after permanent middle c...
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| Veröffentlicht in: | Magnetic resonance imaging 1993, Vol.11 (2), p.241-246 |
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| container_title | Magnetic resonance imaging |
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| creator | Helpern, J.A. Dereski, M.O. Knight, R.A. Ordidge, R.J. Chopp, M. Qing, Z.X. |
| description | Changes in the nuclear magnetic resonance (NMR) parameters of spin-lattice relaxation (
T
1), spin-spin relaxation (
T
2), proton density (ϱ), and water diffusion (
D
NMR) were measured over time together with the histopathological status in three regions of rat brain cortex after permanent middle cerebral artery occlusion (MCA-O). Histological response ranged from severe irreversible damage (necrosis and cavitation) to relatively mild and apparently reversible damage.
D
NMR was the only NMR parameter which demonstrated a statistically significant change in all three regions of brain studied. Additionally, ϱ was significantly increased only in the region of brain studied which eventually progressed to necrosis and cavitation. Finally, data are presented which indicate that changes in
T
2,
D
NMR, and ϱ can occur independently of one another. |
| doi_str_mv | 10.1016/0730-725X(93)90028-C |
| format | Article |
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T
1), spin-spin relaxation (
T
2), proton density (ϱ), and water diffusion (
D
NMR) were measured over time together with the histopathological status in three regions of rat brain cortex after permanent middle cerebral artery occlusion (MCA-O). Histological response ranged from severe irreversible damage (necrosis and cavitation) to relatively mild and apparently reversible damage.
D
NMR was the only NMR parameter which demonstrated a statistically significant change in all three regions of brain studied. Additionally, ϱ was significantly increased only in the region of brain studied which eventually progressed to necrosis and cavitation. Finally, data are presented which indicate that changes in
T
2,
D
NMR, and ϱ can occur independently of one another.</description><identifier>ISSN: 0730-725X</identifier><identifier>EISSN: 1873-5894</identifier><identifier>DOI: 10.1016/0730-725X(93)90028-C</identifier><identifier>PMID: 8455433</identifier><identifier>CODEN: MRIMDQ</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Brain - pathology ; Brain Damage, Chronic - pathology ; Brain Ischemia - pathology ; Cardiovascular system ; Cerebral ischemia ; Diffusion ; Histopathology ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; MRI ; Necrosis ; Neurons - pathology ; NMR ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rats ; Rats, Inbred F344 ; Stroke ; Time Factors</subject><ispartof>Magnetic resonance imaging, 1993, Vol.11 (2), p.241-246</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-60be82d55298e4b941e4305f4daecee32f977808a0aa267427f5698701080b8d3</citedby><cites>FETCH-LOGICAL-c452t-60be82d55298e4b941e4305f4daecee32f977808a0aa267427f5698701080b8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0730-725X(93)90028-C$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4667533$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8455433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helpern, J.A.</creatorcontrib><creatorcontrib>Dereski, M.O.</creatorcontrib><creatorcontrib>Knight, R.A.</creatorcontrib><creatorcontrib>Ordidge, R.J.</creatorcontrib><creatorcontrib>Chopp, M.</creatorcontrib><creatorcontrib>Qing, Z.X.</creatorcontrib><title>Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia</title><title>Magnetic resonance imaging</title><addtitle>Magn Reson Imaging</addtitle><description>Changes in the nuclear magnetic resonance (NMR) parameters of spin-lattice relaxation (
T
1), spin-spin relaxation (
T
2), proton density (ϱ), and water diffusion (
D
NMR) were measured over time together with the histopathological status in three regions of rat brain cortex after permanent middle cerebral artery occlusion (MCA-O). Histological response ranged from severe irreversible damage (necrosis and cavitation) to relatively mild and apparently reversible damage.
D
NMR was the only NMR parameter which demonstrated a statistically significant change in all three regions of brain studied. Additionally, ϱ was significantly increased only in the region of brain studied which eventually progressed to necrosis and cavitation. Finally, data are presented which indicate that changes in
T
2,
D
NMR, and ϱ can occur independently of one another.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain Damage, Chronic - pathology</subject><subject>Brain Ischemia - pathology</subject><subject>Cardiovascular system</subject><subject>Cerebral ischemia</subject><subject>Diffusion</subject><subject>Histopathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MRI</subject><subject>Necrosis</subject><subject>Neurons - pathology</subject><subject>NMR</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Stroke</subject><subject>Time Factors</subject><issn>0730-725X</issn><issn>1873-5894</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo6-zqP1DIQWQ9tFbno5O-LMigrrDgRcFbSKerZyPdSW-SEf33ZnaGOXpKkXrq5eUh5FUL71touw-gODSKyZ_XPX_XAzDdbJ-QTasVb6TuxVOyOSPPyWXOvwBAMi4vyIUWUgrON-Th1ucSV1vu4xx33tmZupgSzrb4GDKNEw17N6NNdLG7gMU7mjDHYIND6uufDzu62mQXLJgy9YHinxWTXzCUQxomHFIdfHb3uHj7gjyb7Jzx5em9Ij8-f_q-vW3uvn35uv141zghWWk6GFCzUUrWaxRDL1oUHOQkRosOkbOpV0qDtmAt65RgapJdrxW0oGHQI78ib4-5a4oPe8zFLLUCzrMNGPfZKNlJ3XFWQXEEXYo5J5zMWtvb9Ne0YA6mzUGjOWg0PTePps22nr0-5e-HBcfz0Ult3b857W2uWqdUjfl8xkTXKfmI3RwxrC5-e0wmO49V7ugTumLG6P_f4x9SLpyE</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Helpern, J.A.</creator><creator>Dereski, M.O.</creator><creator>Knight, R.A.</creator><creator>Ordidge, R.J.</creator><creator>Chopp, M.</creator><creator>Qing, Z.X.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia</title><author>Helpern, J.A. ; Dereski, M.O. ; Knight, R.A. ; Ordidge, R.J. ; Chopp, M. ; Qing, Z.X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-60be82d55298e4b941e4305f4daecee32f977808a0aa267427f5698701080b8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain Damage, Chronic - pathology</topic><topic>Brain Ischemia - pathology</topic><topic>Cardiovascular system</topic><topic>Cerebral ischemia</topic><topic>Diffusion</topic><topic>Histopathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MRI</topic><topic>Necrosis</topic><topic>Neurons - pathology</topic><topic>NMR</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Stroke</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helpern, J.A.</creatorcontrib><creatorcontrib>Dereski, M.O.</creatorcontrib><creatorcontrib>Knight, R.A.</creatorcontrib><creatorcontrib>Ordidge, R.J.</creatorcontrib><creatorcontrib>Chopp, M.</creatorcontrib><creatorcontrib>Qing, Z.X.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helpern, J.A.</au><au>Dereski, M.O.</au><au>Knight, R.A.</au><au>Ordidge, R.J.</au><au>Chopp, M.</au><au>Qing, Z.X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia</atitle><jtitle>Magnetic resonance imaging</jtitle><addtitle>Magn Reson Imaging</addtitle><date>1993</date><risdate>1993</risdate><volume>11</volume><issue>2</issue><spage>241</spage><epage>246</epage><pages>241-246</pages><issn>0730-725X</issn><eissn>1873-5894</eissn><coden>MRIMDQ</coden><abstract>Changes in the nuclear magnetic resonance (NMR) parameters of spin-lattice relaxation (
T
1), spin-spin relaxation (
T
2), proton density (ϱ), and water diffusion (
D
NMR) were measured over time together with the histopathological status in three regions of rat brain cortex after permanent middle cerebral artery occlusion (MCA-O). Histological response ranged from severe irreversible damage (necrosis and cavitation) to relatively mild and apparently reversible damage.
D
NMR was the only NMR parameter which demonstrated a statistically significant change in all three regions of brain studied. Additionally, ϱ was significantly increased only in the region of brain studied which eventually progressed to necrosis and cavitation. Finally, data are presented which indicate that changes in
T
2,
D
NMR, and ϱ can occur independently of one another.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8455433</pmid><doi>10.1016/0730-725X(93)90028-C</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Magnetic resonance imaging, 1993, Vol.11 (2), p.241-246 |
| issn | 0730-725X 1873-5894 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75658632 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Brain - pathology Brain Damage, Chronic - pathology Brain Ischemia - pathology Cardiovascular system Cerebral ischemia Diffusion Histopathology Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences MRI Necrosis Neurons - pathology NMR Radiodiagnosis. Nmr imagery. Nmr spectrometry Rats Rats, Inbred F344 Stroke Time Factors |
| title | Histopathological correlations of nuclear magnetic resonance imaging parameters in experimental cerebral ischemia |
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