Characterisation of [ 3H]gabapentin binding to a novel site in rat brain: homogenate binding studies

The binding characteristics of [ 3H]gabapentin, the radiolabelled analogue of the novel anticonvulsant gabapentin (1-(aminomethyl)cyclohexaneacetic acid) were studied using purified synaptic plasma membranes prepared from rat cerebral cortex. In 10 mM HEPES buffer [ 3H]gabapentin bound to a single p...

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Veröffentlicht in:	European journal of pharmacology 1993-02, Vol.244 (3), p.293-301
Hauptverfasser:	Suman-Chauhan, Nirmala, Webdale, Louise, Hill, David R., Woodruff, Geoffrey N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - metabolism Acetates - pharmacology Amines Amino Acids - metabolism Amino Acids - pharmacology Animals Anticonvulsants Anticonvulsants - metabolism Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Baclofen Baclofen - metabolism Binding Sites - drug effects Biological and medical sciences Cell Membrane - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cyclohexanecarboxylic Acids GABA (γ-aminobutyric acid) GABA A receptors GABA B receptors Gabapentin gamma-Aminobutyric Acid - analogs & derivatives gamma-Aminobutyric Acid - pharmacology Glycine Hydrogen-Ion Concentration Medical sciences Neuropharmacology NMDA (N-methyl-D-aspartate) Pharmacology. Drug treatments Polyamines Rats Receptors, GABA-A - metabolism Receptors, Glycine Receptors, N-Methyl-D-Aspartate - metabolism Receptors, Neurotransmitter - metabolism Spermidine - pharmacology Spermine - pharmacology
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