Dietary fish oil supplementation reduces myocardial infarct size in a canine model of ischemia and reperfusion

Objectives. This study was conducted to determine whether the long-term administration of ish foil attenuates myocardial necrosis in an occlusion-reperfusion model of myocardial ischemia. Background. Omega-3 fatty acids found in fish oil have various biologic properties that may modify myocardial in...

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Veröffentlicht in:Journal of the American College of Cardiology 1993-04, Vol.21 (5), p.1280-1285
Hauptverfasser: Oskarsson, Helgi J., Godwin, John, Gunnar, Rolf M., Thomas, John X.
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container_issue 5
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container_title Journal of the American College of Cardiology
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creator Oskarsson, Helgi J.
Godwin, John
Gunnar, Rolf M.
Thomas, John X.
description Objectives. This study was conducted to determine whether the long-term administration of ish foil attenuates myocardial necrosis in an occlusion-reperfusion model of myocardial ischemia. Background. Omega-3 fatty acids found in fish oil have various biologic properties that may modify myocardial injury caused by severe ischemia and reperfusion. Methods. Of 21 dogs fed an identical diet, 10 were given supplemental fish oil containing 0.06 g/kg per day of eicosapentaenoic acid for 6 weeks. Under anesthesia and open chest conditions, the left circumflex coronary artery was occluded for 90 min, followed by 6 h of reperfusion. Regional myocardial blood flow was measured with 15-μm spheres before and during occlusion and during reperfusion. The area at risk and infarct size were measured using standard staining techniques. Results. In the dogs receiving supplemental fish oil, the platelet cell membrane content of eicosapentaenoic acid increased from 0.9 ± 0.56% to 7.1 ± 4.0% (p < 0.001). Infarct size was 29 ± 7% in the control group and 13 ± 3% in the fish oil group (p < 0.05). There was no significant difference in the myocardial area at risk or rate-pressure product between the control and fish oil groups. There was no difference in regional myocardial blood flow between the groups at baseline study or during coronary occlusion and reperfusion. Conclusions. Dietary fish oil supplementation significantly reduced myocardial infarct size in this model. The difference in infarct size did not appear to be related to dissimilarities in regional myocardial blood flow or determinants of oxygen consumption. Further investigation is needed to determine the nature of the protective mechanisms of omega-3 fatty acids on myocardial infarct size.
doi_str_mv 10.1016/0735-1097(93)90257-2
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This study was conducted to determine whether the long-term administration of ish foil attenuates myocardial necrosis in an occlusion-reperfusion model of myocardial ischemia. Background. Omega-3 fatty acids found in fish oil have various biologic properties that may modify myocardial injury caused by severe ischemia and reperfusion. Methods. Of 21 dogs fed an identical diet, 10 were given supplemental fish oil containing 0.06 g/kg per day of eicosapentaenoic acid for 6 weeks. Under anesthesia and open chest conditions, the left circumflex coronary artery was occluded for 90 min, followed by 6 h of reperfusion. Regional myocardial blood flow was measured with 15-μm spheres before and during occlusion and during reperfusion. The area at risk and infarct size were measured using standard staining techniques. Results. In the dogs receiving supplemental fish oil, the platelet cell membrane content of eicosapentaenoic acid increased from 0.9 ± 0.56% to 7.1 ± 4.0% (p &lt; 0.001). Infarct size was 29 ± 7% in the control group and 13 ± 3% in the fish oil group (p &lt; 0.05). There was no significant difference in the myocardial area at risk or rate-pressure product between the control and fish oil groups. There was no difference in regional myocardial blood flow between the groups at baseline study or during coronary occlusion and reperfusion. Conclusions. Dietary fish oil supplementation significantly reduced myocardial infarct size in this model. The difference in infarct size did not appear to be related to dissimilarities in regional myocardial blood flow or determinants of oxygen consumption. Further investigation is needed to determine the nature of the protective mechanisms of omega-3 fatty acids on myocardial infarct size.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/0735-1097(93)90257-2</identifier><identifier>PMID: 8459088</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Case-Control Studies ; Coronary Circulation - drug effects ; Diseases of the cardiovascular system ; Docosahexaenoic Acids - pharmacology ; Docosahexaenoic Acids - therapeutic use ; Dogs ; Eicosapentaenoic Acid - pharmacology ; Eicosapentaenoic Acid - therapeutic use ; Fatty Acids - blood ; Female ; Fish Oils - pharmacology ; Fish Oils - therapeutic use ; Male ; Medical sciences ; Myocardial Infarction - blood ; Myocardial Infarction - etiology ; Myocardial Infarction - therapy ; Myocardial Ischemia - complications ; Myocardial Reperfusion ; Myocardium - pathology ; Necrosis ; Radiotherapy. 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This study was conducted to determine whether the long-term administration of ish foil attenuates myocardial necrosis in an occlusion-reperfusion model of myocardial ischemia. Background. Omega-3 fatty acids found in fish oil have various biologic properties that may modify myocardial injury caused by severe ischemia and reperfusion. Methods. Of 21 dogs fed an identical diet, 10 were given supplemental fish oil containing 0.06 g/kg per day of eicosapentaenoic acid for 6 weeks. Under anesthesia and open chest conditions, the left circumflex coronary artery was occluded for 90 min, followed by 6 h of reperfusion. Regional myocardial blood flow was measured with 15-μm spheres before and during occlusion and during reperfusion. The area at risk and infarct size were measured using standard staining techniques. Results. In the dogs receiving supplemental fish oil, the platelet cell membrane content of eicosapentaenoic acid increased from 0.9 ± 0.56% to 7.1 ± 4.0% (p &lt; 0.001). Infarct size was 29 ± 7% in the control group and 13 ± 3% in the fish oil group (p &lt; 0.05). There was no significant difference in the myocardial area at risk or rate-pressure product between the control and fish oil groups. There was no difference in regional myocardial blood flow between the groups at baseline study or during coronary occlusion and reperfusion. Conclusions. Dietary fish oil supplementation significantly reduced myocardial infarct size in this model. The difference in infarct size did not appear to be related to dissimilarities in regional myocardial blood flow or determinants of oxygen consumption. Further investigation is needed to determine the nature of the protective mechanisms of omega-3 fatty acids on myocardial infarct size.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Coronary Circulation - drug effects</subject><subject>Diseases of the cardiovascular system</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Docosahexaenoic Acids - therapeutic use</subject><subject>Dogs</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Eicosapentaenoic Acid - therapeutic use</subject><subject>Fatty Acids - blood</subject><subject>Female</subject><subject>Fish Oils - pharmacology</subject><subject>Fish Oils - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Reperfusion</subject><subject>Myocardium - pathology</subject><subject>Necrosis</subject><subject>Radiotherapy. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oskarsson, Helgi J.</creatorcontrib><creatorcontrib>Godwin, John</creatorcontrib><creatorcontrib>Gunnar, Rolf M.</creatorcontrib><creatorcontrib>Thomas, John X.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oskarsson, Helgi J.</au><au>Godwin, John</au><au>Gunnar, Rolf M.</au><au>Thomas, John X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary fish oil supplementation reduces myocardial infarct size in a canine model of ischemia and reperfusion</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>21</volume><issue>5</issue><spage>1280</spage><epage>1285</epage><pages>1280-1285</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>Objectives. This study was conducted to determine whether the long-term administration of ish foil attenuates myocardial necrosis in an occlusion-reperfusion model of myocardial ischemia. Background. Omega-3 fatty acids found in fish oil have various biologic properties that may modify myocardial injury caused by severe ischemia and reperfusion. Methods. Of 21 dogs fed an identical diet, 10 were given supplemental fish oil containing 0.06 g/kg per day of eicosapentaenoic acid for 6 weeks. Under anesthesia and open chest conditions, the left circumflex coronary artery was occluded for 90 min, followed by 6 h of reperfusion. Regional myocardial blood flow was measured with 15-μm spheres before and during occlusion and during reperfusion. The area at risk and infarct size were measured using standard staining techniques. Results. In the dogs receiving supplemental fish oil, the platelet cell membrane content of eicosapentaenoic acid increased from 0.9 ± 0.56% to 7.1 ± 4.0% (p &lt; 0.001). Infarct size was 29 ± 7% in the control group and 13 ± 3% in the fish oil group (p &lt; 0.05). There was no significant difference in the myocardial area at risk or rate-pressure product between the control and fish oil groups. There was no difference in regional myocardial blood flow between the groups at baseline study or during coronary occlusion and reperfusion. Conclusions. Dietary fish oil supplementation significantly reduced myocardial infarct size in this model. The difference in infarct size did not appear to be related to dissimilarities in regional myocardial blood flow or determinants of oxygen consumption. Further investigation is needed to determine the nature of the protective mechanisms of omega-3 fatty acids on myocardial infarct size.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8459088</pmid><doi>10.1016/0735-1097(93)90257-2</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Animals
Biological and medical sciences
Case-Control Studies
Coronary Circulation - drug effects
Diseases of the cardiovascular system
Docosahexaenoic Acids - pharmacology
Docosahexaenoic Acids - therapeutic use
Dogs
Eicosapentaenoic Acid - pharmacology
Eicosapentaenoic Acid - therapeutic use
Fatty Acids - blood
Female
Fish Oils - pharmacology
Fish Oils - therapeutic use
Male
Medical sciences
Myocardial Infarction - blood
Myocardial Infarction - etiology
Myocardial Infarction - therapy
Myocardial Ischemia - complications
Myocardial Reperfusion
Myocardium - pathology
Necrosis
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
title Dietary fish oil supplementation reduces myocardial infarct size in a canine model of ischemia and reperfusion
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