Markedly Prolonged Incubation Period of Hepatitis B in a Chimpanzee Passively Immunized with a Human Monoclonal Antibody to the a Determinant of Hepatitis B Surface Antigen
The protective efficacy of a human monoclonal antibody directed against the a determinant of hepatitis B virus (HBV) surface antigen was studied in a chimpanzee. A single high dose of 5 mg/kg (body weight) of monoclonal antibody SDZ OST 577 was intravenously administered to a chimpanzee, followed by...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1993-04, Vol.90 (7), p.3014-3018 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Ogata, Norio Ostberg, Lars Ehrlich, Paul H. Wong, Doris C. Miller, Roger H. Purcell, Robert H. |
| description | The protective efficacy of a human monoclonal antibody directed against the a determinant of hepatitis B virus (HBV) surface antigen was studied in a chimpanzee. A single high dose of 5 mg/kg (body weight) of monoclonal antibody SDZ OST 577 was intravenously administered to a chimpanzee, followed by intravenous challenge with 103.5chimpanzee infectious doses of a wild-type HBV, the MS-2 strain (ayw subtype). The passively acquired antibody to HBV surface antigen could be detected for 40 weeks. Serum HBV DNA tested by a "nested" polymerase chain reaction assay was negative through the 36th week after virus challenge but became positive by the 38th week. The chimpanzee subsequently developed acute hepatitis B ≈ 1 year after challenge. The nucleotide sequence of the a determinant of the surface gene of the replicated virus was identical with that of the inoculated wild-type virus. Thus, a human monoclonal antibody directed against the a determinant of HBV surface antigen delayed but did not prevent experimental infection of HBV and hepatitis in the chimpanzee. Our results indicate an incomplete ability of this antibody to protect against HBV infection in vivo after a single infusion. |
| doi_str_mv | 10.1073/pnas.90.7.3014 |
| format | Article |
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A single high dose of 5 mg/kg (body weight) of monoclonal antibody SDZ OST 577 was intravenously administered to a chimpanzee, followed by intravenous challenge with 103.5chimpanzee infectious doses of a wild-type HBV, the MS-2 strain (ayw subtype). The passively acquired antibody to HBV surface antigen could be detected for 40 weeks. Serum HBV DNA tested by a "nested" polymerase chain reaction assay was negative through the 36th week after virus challenge but became positive by the 38th week. The chimpanzee subsequently developed acute hepatitis B ≈ 1 year after challenge. The nucleotide sequence of the a determinant of the surface gene of the replicated virus was identical with that of the inoculated wild-type virus. Thus, a human monoclonal antibody directed against the a determinant of HBV surface antigen delayed but did not prevent experimental infection of HBV and hepatitis in the chimpanzee. Our results indicate an incomplete ability of this antibody to protect against HBV infection in vivo after a single infusion.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.90.7.3014</identifier><identifier>PMID: 8464917</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Animals ; Antibodies ; Antibodies, Monoclonal - administration & dosage ; Base Sequence ; Biological and medical sciences ; Chimpanzees ; DNA ; DNA, Viral - blood ; DNA, Viral - genetics ; DNA, Viral - isolation & purification ; Dosage ; Fundamental and applied biological sciences. Psychology ; Hepatitis ; Hepatitis antigens ; Hepatitis B ; Hepatitis B - blood ; Hepatitis B - immunology ; Hepatitis B - physiopathology ; Hepatitis B Surface Antigens - immunology ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Humans ; Immunization, Passive ; Infections ; Liver ; Medical research ; Microbiology ; Molecular Sequence Data ; Monkeys & apes ; Monoclonal antibodies ; Oligodeoxyribonucleotides ; Pan troglodytes ; Polymerase Chain Reaction - methods ; Time Factors ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Virology ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1993-04, Vol.90 (7), p.3014-3018</ispartof><rights>Copyright 1993 The National Academy of Sciences of the United States of America</rights><rights>1993 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Apr 1, 1993</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4594-7b187cab799a1fee3fc949fc55ec552ab2698e72b305b0750488ebb09c6c415e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/90/7.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2361669$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2361669$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4740133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8464917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogata, Norio</creatorcontrib><creatorcontrib>Ostberg, Lars</creatorcontrib><creatorcontrib>Ehrlich, Paul H.</creatorcontrib><creatorcontrib>Wong, Doris C.</creatorcontrib><creatorcontrib>Miller, Roger H.</creatorcontrib><creatorcontrib>Purcell, Robert H.</creatorcontrib><title>Markedly Prolonged Incubation Period of Hepatitis B in a Chimpanzee Passively Immunized with a Human Monoclonal Antibody to the a Determinant of Hepatitis B Surface Antigen</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The protective efficacy of a human monoclonal antibody directed against the a determinant of hepatitis B virus (HBV) surface antigen was studied in a chimpanzee. A single high dose of 5 mg/kg (body weight) of monoclonal antibody SDZ OST 577 was intravenously administered to a chimpanzee, followed by intravenous challenge with 103.5chimpanzee infectious doses of a wild-type HBV, the MS-2 strain (ayw subtype). The passively acquired antibody to HBV surface antigen could be detected for 40 weeks. Serum HBV DNA tested by a "nested" polymerase chain reaction assay was negative through the 36th week after virus challenge but became positive by the 38th week. The chimpanzee subsequently developed acute hepatitis B ≈ 1 year after challenge. The nucleotide sequence of the a determinant of the surface gene of the replicated virus was identical with that of the inoculated wild-type virus. Thus, a human monoclonal antibody directed against the a determinant of HBV surface antigen delayed but did not prevent experimental infection of HBV and hepatitis in the chimpanzee. Our results indicate an incomplete ability of this antibody to protect against HBV infection in vivo after a single infusion.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Chimpanzees</subject><subject>DNA</subject><subject>DNA, Viral - blood</subject><subject>DNA, Viral - genetics</subject><subject>DNA, Viral - isolation & purification</subject><subject>Dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatitis</subject><subject>Hepatitis antigens</subject><subject>Hepatitis B</subject><subject>Hepatitis B - blood</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B - physiopathology</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Humans</subject><subject>Immunization, Passive</subject><subject>Infections</subject><subject>Liver</subject><subject>Medical research</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Monkeys & apes</subject><subject>Monoclonal antibodies</subject><subject>Oligodeoxyribonucleotides</subject><subject>Pan troglodytes</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Time Factors</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Virology</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuO0zAYhSMEGsrAlhVIFkKza7EdJ44lNkO5tNKMqASsLcf907okdrCdgc4z8ZC4tFRlFrCwLPl85_h2suwpwROCef6qtypMBJ7wSY4Ju5eNCBZkXDKB72cjjCkfV4yyh9mjEDYYY1FU-Cw7q1giCB9lP6-V_wrLdosW3rXOrmCJ5lYPtYrGWbQAb9wSuQbNoE9L0QT0BhmLFJquTdcrewuAFioEcwMpZN51gzW3KeS7ietEzYZOWXTtrNMpXbXo0kZTu-UWRYfiGhLyFiL4zlhl492NPg2-URp-m1ZgH2cPGtUGeHKYz7Mv7999ns7GVx8_zKeXV2PNCsHGvCYV16rmQijSAOSNFkw0uiggDapqWooKOK1zXNSYF5hVFdQ1FrrUjBSQn2ev97n9UHew1GCjV63svemU30qnjPxbsWYtV-5GspJSnuwXB7t33wYIUXYmaGhbZcENQfKiLDgh_wdJ-iRaYJHAF3fAjRt8es4gKSa0xIKyBE32kPYuBA_N8cAEy11X5K4rUmDJ5a4ryfD89JpH_FCOpL886Cpo1TZeWW3CEWOcYZLnJzG7-D_q6TYX_9JlM7RthB8xgc_24CZE548kzUtSliL_BRV86vo</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Ogata, Norio</creator><creator>Ostberg, Lars</creator><creator>Ehrlich, Paul H.</creator><creator>Wong, Doris C.</creator><creator>Miller, Roger H.</creator><creator>Purcell, Robert H.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19930401</creationdate><title>Markedly Prolonged Incubation Period of Hepatitis B in a Chimpanzee Passively Immunized with a Human Monoclonal Antibody to the a Determinant of Hepatitis B Surface Antigen</title><author>Ogata, Norio ; Ostberg, Lars ; Ehrlich, Paul H. ; Wong, Doris C. ; Miller, Roger H. ; Purcell, Robert H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4594-7b187cab799a1fee3fc949fc55ec552ab2698e72b305b0750488ebb09c6c415e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Monoclonal - administration & dosage</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Chimpanzees</topic><topic>DNA</topic><topic>DNA, Viral - blood</topic><topic>DNA, Viral - genetics</topic><topic>DNA, Viral - isolation & purification</topic><topic>Dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepatitis</topic><topic>Hepatitis antigens</topic><topic>Hepatitis B</topic><topic>Hepatitis B - blood</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B - physiopathology</topic><topic>Hepatitis B Surface Antigens - immunology</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Humans</topic><topic>Immunization, Passive</topic><topic>Infections</topic><topic>Liver</topic><topic>Medical research</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Monkeys & apes</topic><topic>Monoclonal antibodies</topic><topic>Oligodeoxyribonucleotides</topic><topic>Pan troglodytes</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Time Factors</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogata, Norio</creatorcontrib><creatorcontrib>Ostberg, Lars</creatorcontrib><creatorcontrib>Ehrlich, Paul H.</creatorcontrib><creatorcontrib>Wong, Doris C.</creatorcontrib><creatorcontrib>Miller, Roger H.</creatorcontrib><creatorcontrib>Purcell, Robert H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogata, Norio</au><au>Ostberg, Lars</au><au>Ehrlich, Paul H.</au><au>Wong, Doris C.</au><au>Miller, Roger H.</au><au>Purcell, Robert H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Markedly Prolonged Incubation Period of Hepatitis B in a Chimpanzee Passively Immunized with a Human Monoclonal Antibody to the a Determinant of Hepatitis B Surface Antigen</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>90</volume><issue>7</issue><spage>3014</spage><epage>3018</epage><pages>3014-3018</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>The protective efficacy of a human monoclonal antibody directed against the a determinant of hepatitis B virus (HBV) surface antigen was studied in a chimpanzee. A single high dose of 5 mg/kg (body weight) of monoclonal antibody SDZ OST 577 was intravenously administered to a chimpanzee, followed by intravenous challenge with 103.5chimpanzee infectious doses of a wild-type HBV, the MS-2 strain (ayw subtype). The passively acquired antibody to HBV surface antigen could be detected for 40 weeks. Serum HBV DNA tested by a "nested" polymerase chain reaction assay was negative through the 36th week after virus challenge but became positive by the 38th week. The chimpanzee subsequently developed acute hepatitis B ≈ 1 year after challenge. The nucleotide sequence of the a determinant of the surface gene of the replicated virus was identical with that of the inoculated wild-type virus. Thus, a human monoclonal antibody directed against the a determinant of HBV surface antigen delayed but did not prevent experimental infection of HBV and hepatitis in the chimpanzee. Our results indicate an incomplete ability of this antibody to protect against HBV infection in vivo after a single infusion.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8464917</pmid><doi>10.1073/pnas.90.7.3014</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1993-04, Vol.90 (7), p.3014-3018 |
| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino Acid Sequence Animals Antibodies Antibodies, Monoclonal - administration & dosage Base Sequence Biological and medical sciences Chimpanzees DNA DNA, Viral - blood DNA, Viral - genetics DNA, Viral - isolation & purification Dosage Fundamental and applied biological sciences. Psychology Hepatitis Hepatitis antigens Hepatitis B Hepatitis B - blood Hepatitis B - immunology Hepatitis B - physiopathology Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Humans Immunization, Passive Infections Liver Medical research Microbiology Molecular Sequence Data Monkeys & apes Monoclonal antibodies Oligodeoxyribonucleotides Pan troglodytes Polymerase Chain Reaction - methods Time Factors Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Virology Viruses |
| title | Markedly Prolonged Incubation Period of Hepatitis B in a Chimpanzee Passively Immunized with a Human Monoclonal Antibody to the a Determinant of Hepatitis B Surface Antigen |
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