Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP

Acetoxymethyl esters of alkyl or aryl phosphates can be prepared by reacting their trialkylammonium or silver salts with acetoxymethyl bromide. Because acetoxymethyl esters are rapidly cleaved intracellularly, they facilitate the delivery of organophosphates into the cytoplasm without puncturing or...

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Veröffentlicht in:	The Journal of biological chemistry 1993-03, Vol.268 (9), p.6316-6322
Hauptverfasser:	SCHULTZ, C, MANA VAJANAPHANICH, HAROOTUNIAN, A. T, SAMMAK, P. J, BARRETT, K. E, TSIEN, R. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	acetoxymethyl Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Biological Transport Cell Line Cell Membrane Permeability cell membranes Chlorides - metabolism cyclic AMP Cyclic AMP - metabolism Cyclic GMP - metabolism Enzyme Activation epithelium esters Esters - chemistry Esters - metabolism fibroblasts Fishes Fundamental and applied biological sciences. Psychology Humans Hydrolysis intestine man Melanophores - metabolism Molecular Structure Nucleic acids Nucleic bases, nucleotides permeability Protein Kinases - metabolism Second Messenger Systems
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