[ 3H]p-Aminoclonidine and [ 3H]idazoxan label different populations of imidazoline sites on rat kidney

In the presence of RS-15385-197 to preclude binding to α 2-adrenoceptors, [ 3H]p-aminoclonidine labelled a low affinity high capacity site, (K d = 127.6±19.7 nM, B max 978±172 fmol/mg proteins) whereas [ 3H]idazoxan labelled a high affinity low capacity site (K d = 1.66±0.28 nM, B max 45.3±11.4 fmol...

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