Sources of hydrogen abstraction by activated neocarzinostatin chromophore

Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA. Since hydrogen abstraction from DNA accounts for only part of the hyd...

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Veröffentlicht in:	Biochemistry (Easton) 1993-04, Vol.32 (14), p.3611-3616
Hauptverfasser:	Chin, Der Hang, Goldberg, Irving H
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid Deuterium DNA Damage Enediynes General pharmacology Glutathione - pharmacology Hydrogen - chemistry Hydrogen Bonding Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Solvents Stereoisomerism Sulfhydryl Compounds - pharmacology Zinostatin - analogs & derivatives Zinostatin - chemistry Zinostatin - pharmacology
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