Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy

Soluble human interleukin‐6 receptor (sIL‐6R) was measured in the serum of 30 healthy individuals, 32 individuals with monoclonal gammopathy of undetermined significance (MGUS), 20 patients with early multiple myeloma (MM) and 54 patients with overt MM. The serum activity recognized by an immunoradi...

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Veröffentlicht in:	European journal of immunology 1993-04, Vol.23 (4), p.820-824
Hauptverfasser:	Gaillard, Jean‐Philippe, Bataille, Régis, Brailly, Hervé, Zuber, Caroline, Yasukawa, Kiyoshi, Attal, Michel, Maruo, Naoko, Taga, Tetsuya, Kishimoto, Tadamitsu, Klein, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Female Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Interleukin-6 - metabolism Interleukin‐6 Male Medical sciences Monoclonal gammopathy Monoclonal Gammopathy of Undetermined Significance - blood Multiple Myeloma - blood Receptors, Immunologic - chemistry Receptors, Immunologic - metabolism Receptors, Interleukin-6 Solubility Soluble interleukin‐6 receptor Time Factors
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Zusammenfassung:	Soluble human interleukin‐6 receptor (sIL‐6R) was measured in the serum of 30 healthy individuals, 32 individuals with monoclonal gammopathy of undetermined significance (MGUS), 20 patients with early multiple myeloma (MM) and 54 patients with overt MM. The serum activity recognized by an immunoradiometric assay was determined to be sIL‐6R, because of its binding capacity to IL‐6 and its molecular mass of 55 kDa. All sera of healthy individuals contained sIL‐6R (mean value: 89 ng/ml, range 17‐300 ng/ml). Serum sIL‐6R levels were increased by 51% in patients with MGUS (mean value: 135 ng/ml, p
ISSN:	0014-2980 1521-4141
DOI:	10.1002/eji.1830230408