Cholinergic hyperactivity and negative symptoms: behavioral effects of physostigmine in normal controls

Intravenous infusion of physostigmine (a centrally active anticholinesterase agent) in normal subjects leads to a syndrome of psychomotor inhibition; this has been proposed as a model for selected symptoms of depression. In view of its similarity to the negative schizophrenic syndrome, we compared t...

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Veröffentlicht in:	Schizophrenia research 1993-03, Vol.9 (1), p.19-23
Hauptverfasser:	Tandon, Rajiv, Greden, John F., Haskett, Roger F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Affect - drug effects Arousal - drug effects Biological and medical sciences Cholinergic Cholinergic Fibers - drug effects Depression Humans Infusions, Intravenous Male Medical sciences Motivation N-Methylscopolamine Negative symptom Parasympatholytics - pharmacology Physostigmine Physostigmine - analogs & derivatives Physostigmine - pharmacology Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychopathology. Psychiatry Psychoses Reaction Time - drug effects Receptors, Cholinergic - drug effects Schizophrenia Schizophrenic Psychology Scopolamine Derivatives - pharmacology Single-Blind Method Social Behavior
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