Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2
Interleukin-8 (IL-8), neutrophil activating peptide-2 (NAP-2), and growth regulated gene (GRO, also known as melanoma growth stimulatory activity) are members of a family of peptides which are chemotactic agents for inflammatory cells such as neutrophils. Receptors have been identified for IL-8, GRO...
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| Veröffentlicht in: | Molecular immunology 1993-03, Vol.30 (4), p.359-367 |
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| creator | Pat Cerretti, Douglas Kozlosky, Carl J. Bos, Tim Vanden Nelson, Nicole Gearing, David P. Beckmann, M.Patricia |
| description | Interleukin-8 (IL-8), neutrophil activating peptide-2 (NAP-2), and growth regulated gene (GRO, also known as melanoma growth stimulatory activity) are members of a family of peptides which are chemotactic agents for inflammatory cells such as neutrophils. Receptors have been identified for IL-8, GRO and NAP-2 on human neutrophils and granulocytic cell lines, and it has been observed that these cytokines can cross-compete for binding to a common receptor. Using the recently characterized rabbit IL-8 receptor as a probe, two classes of cDNAs, termed type 1 and type 2, were isolated from a human neutrophil library. The type 1 receptor binds only IL-8 while the type 2 receptor binds IL-8, GRO and NAP-2 at high affinity when respective cDNAs are expressed in COS-7 cells. The two cDNAs encode proteins that have an amino acid sequence identity of 77% while the type 1 and 2 receptors have an identity of 84 and 74% with the rabbit IL-8 receptor. These receptors also show significant homology with receptors for other chemotactic agents and with potential coding regions from the human cytomegalovirus genome. |
| doi_str_mv | 10.1016/0161-5890(93)90065-J |
| format | Article |
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Receptors have been identified for IL-8, GRO and NAP-2 on human neutrophils and granulocytic cell lines, and it has been observed that these cytokines can cross-compete for binding to a common receptor. Using the recently characterized rabbit IL-8 receptor as a probe, two classes of cDNAs, termed type 1 and type 2, were isolated from a human neutrophil library. The type 1 receptor binds only IL-8 while the type 2 receptor binds IL-8, GRO and NAP-2 at high affinity when respective cDNAs are expressed in COS-7 cells. The two cDNAs encode proteins that have an amino acid sequence identity of 77% while the type 1 and 2 receptors have an identity of 84 and 74% with the rabbit IL-8 receptor. These receptors also show significant homology with receptors for other chemotactic agents and with potential coding regions from the human cytomegalovirus genome.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/0161-5890(93)90065-J</identifier><identifier>PMID: 8384312</identifier><identifier>CODEN: MOIMD5</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amino Acid Sequence ; Animals ; beta-Thromboglobulin ; Biological and medical sciences ; Cell Line ; Cell receptors ; Cell structures and functions ; Cells, Cultured ; Chemokine CXCL1 ; Chemokines, CXC ; Chemotactic Factors - metabolism ; DNA - isolation & purification ; Dose-Response Relationship, Drug ; Fundamental and applied biological sciences. 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These receptors also show significant homology with receptors for other chemotactic agents and with potential coding regions from the human cytomegalovirus genome.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>beta-Thromboglobulin</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cells, Cultured</subject><subject>Chemokine CXCL1</subject><subject>Chemokines, CXC</subject><subject>Chemotactic Factors - metabolism</subject><subject>DNA - isolation & purification</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Granulocytes - metabolism</subject><subject>Growth Substances - metabolism</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins</subject><subject>Interleukin-8 - metabolism</subject><subject>Leukemia, Myeloid</subject><subject>Mice</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Neutrophils - metabolism</subject><subject>Peptides - metabolism</subject><subject>Receptors, Cell Surface - chemistry</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Cytokine</subject><subject>Receptors, Immunologic - chemistry</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Interleukin-8A</subject><subject>Sequence Alignment</subject><subject>Sequence Homology, Amino Acid</subject><subject>Tumor Cells, Cultured</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdFqFDEUhoModVt9A4VciFRw7CSZyUxuBClaLZWC6HXIJme60ZlkmmQq9R18Z8-6y17qRUjI_53_JOcn5Bmr37CayTNcrGp7VZ8q8UrVtWyrywdkxfqOV4o1_CFZHZDH5Djn7zVCiB2Ro170jWB8RX5_jiPYZTSJ2o1JxhZI_pcpPgYaB5rAwlxiynSIiW6WyQTqAzIjLD98qPrX9OLL9dkEowlxMvQmxZ9lU-XiJ_TEwnuKlv7OFzwERwMsJcV548fdPTYKN3TGHt5BxZ-QR4MZMzzd7yfk24f3X88_VlfXF5_O311VthVNqXhTS-OsWHOmGmE6PnR9J5xlclgztVaiBQmyM0JCZ3vXoySd44PDebRGDuKEvNz5zineLpCLnny2MOIvIC5Zd61sOePyvyCTjRKy6xFsdqBNMecEg56Tn0y616zW27j0Ngu9zUIrof_GpS-x7Pnef1lP4A5F-3xQf7HXTbZmHJIJ1ucD1shOKiEQe7vDAId25yHpbD0EC85jgkW76P_9jj_UOrQ_</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Pat Cerretti, Douglas</creator><creator>Kozlosky, Carl J.</creator><creator>Bos, Tim Vanden</creator><creator>Nelson, Nicole</creator><creator>Gearing, David P.</creator><creator>Beckmann, M.Patricia</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2</title><author>Pat Cerretti, Douglas ; Kozlosky, Carl J. ; Bos, Tim Vanden ; Nelson, Nicole ; Gearing, David P. ; Beckmann, M.Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-2406adc3b21943a72f7873dc16fb19b935e6e67a36e7c8d83dc6dd2fd0165a6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>beta-Thromboglobulin</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cells, Cultured</topic><topic>Chemokine CXCL1</topic><topic>Chemokines, CXC</topic><topic>Chemotactic Factors - metabolism</topic><topic>DNA - isolation & purification</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Granulocytes - metabolism</topic><topic>Growth Substances - metabolism</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins</topic><topic>Interleukin-8 - metabolism</topic><topic>Leukemia, Myeloid</topic><topic>Mice</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Neutrophils - metabolism</topic><topic>Peptides - metabolism</topic><topic>Receptors, Cell Surface - chemistry</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Cytokine</topic><topic>Receptors, Immunologic - chemistry</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Interleukin-8A</topic><topic>Sequence Alignment</topic><topic>Sequence Homology, Amino Acid</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pat Cerretti, Douglas</creatorcontrib><creatorcontrib>Kozlosky, Carl J.</creatorcontrib><creatorcontrib>Bos, Tim Vanden</creatorcontrib><creatorcontrib>Nelson, Nicole</creatorcontrib><creatorcontrib>Gearing, David P.</creatorcontrib><creatorcontrib>Beckmann, M.Patricia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pat Cerretti, Douglas</au><au>Kozlosky, Carl J.</au><au>Bos, Tim Vanden</au><au>Nelson, Nicole</au><au>Gearing, David P.</au><au>Beckmann, M.Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>30</volume><issue>4</issue><spage>359</spage><epage>367</epage><pages>359-367</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><coden>MOIMD5</coden><abstract>Interleukin-8 (IL-8), neutrophil activating peptide-2 (NAP-2), and growth regulated gene (GRO, also known as melanoma growth stimulatory activity) are members of a family of peptides which are chemotactic agents for inflammatory cells such as neutrophils. Receptors have been identified for IL-8, GRO and NAP-2 on human neutrophils and granulocytic cell lines, and it has been observed that these cytokines can cross-compete for binding to a common receptor. Using the recently characterized rabbit IL-8 receptor as a probe, two classes of cDNAs, termed type 1 and type 2, were isolated from a human neutrophil library. The type 1 receptor binds only IL-8 while the type 2 receptor binds IL-8, GRO and NAP-2 at high affinity when respective cDNAs are expressed in COS-7 cells. The two cDNAs encode proteins that have an amino acid sequence identity of 77% while the type 1 and 2 receptors have an identity of 84 and 74% with the rabbit IL-8 receptor. 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| identifier | ISSN: 0161-5890 |
| ispartof | Molecular immunology, 1993-03, Vol.30 (4), p.359-367 |
| issn | 0161-5890 1872-9142 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75652126 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals beta-Thromboglobulin Biological and medical sciences Cell Line Cell receptors Cell structures and functions Cells, Cultured Chemokine CXCL1 Chemokines, CXC Chemotactic Factors - metabolism DNA - isolation & purification Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Granulocytes - metabolism Growth Substances - metabolism Humans Intercellular Signaling Peptides and Proteins Interleukin-8 - metabolism Leukemia, Myeloid Mice Miscellaneous Molecular and cellular biology Molecular Sequence Data Neoplasm Proteins - metabolism Neutrophils - metabolism Peptides - metabolism Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Receptors, Cytokine Receptors, Immunologic - chemistry Receptors, Immunologic - metabolism Receptors, Interleukin-8A Sequence Alignment Sequence Homology, Amino Acid Tumor Cells, Cultured |
| title | Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2 |
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