Olfactory memory in unmedicated schizophrenics
Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory defici...
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| Veröffentlicht in: | Schizophrenia research 1993-03, Vol.9 (1), p.41-47 |
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| container_end_page | 47 |
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| container_title | Schizophrenia research |
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| creator | Wu, Joseph Buchsbaum, Monte S. Moy, Ken Denlea, Nancy Kesslak, Pat Tseng, Henry Plosnaj, Diane Hetu, Martin Potkin, Stephen Bracha, Stefan Cotman, Carl |
| description | Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four normal subjects and twenty unmedicated schizophrenic patients were examined with two tests of olfactory function: the University of Pennsylvania Smell Identification Test (UPSIT) and a match-to-sample olfactory memory test. Results indicated that schizophrenics did poorly on both the UPSIT and the olfactory match-to-sample memory test relative to sex and age-matched controls. ANCOVA showed that the deficit in performance on the olfactory match-to-sample test was still present even when the variance due to the UPSIT was taken out of the analysis. Deficits in olfactory identification and olfactory memory are consistent with the concept that schizophrenics have dysfunctional limbic systems. |
| doi_str_mv | 10.1016/0920-9964(93)90008-7 |
| format | Article |
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The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four normal subjects and twenty unmedicated schizophrenic patients were examined with two tests of olfactory function: the University of Pennsylvania Smell Identification Test (UPSIT) and a match-to-sample olfactory memory test. Results indicated that schizophrenics did poorly on both the UPSIT and the olfactory match-to-sample memory test relative to sex and age-matched controls. ANCOVA showed that the deficit in performance on the olfactory match-to-sample test was still present even when the variance due to the UPSIT was taken out of the analysis. Deficits in olfactory identification and olfactory memory are consistent with the concept that schizophrenics have dysfunctional limbic systems.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/0920-9964(93)90008-7</identifier><identifier>PMID: 8068050</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Blood Glucose - metabolism ; Brain - diagnostic imaging ; Deoxyglucose - analogs & derivatives ; Deoxyglucose - metabolism ; Discrimination Learning - physiology ; Fluorodeoxyglucose F18 ; Frontal lobe ; Frontal Lobe - diagnostic imaging ; Frontal Lobe - physiopathology ; Hippocampus ; Humans ; Mental Recall - physiology ; Positron emission tomography ; Schizophrenia - diagnostic imaging ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Sensory Thresholds - physiology ; Smell - physiology ; Smell Identification Test ; Tomography, Emission-Computed</subject><ispartof>Schizophrenia research, 1993-03, Vol.9 (1), p.41-47</ispartof><rights>1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-f36d9b4bde78b6b886daf183f77e8d99b0d53b7d9db3148cd89ca16ff6e18323</citedby><cites>FETCH-LOGICAL-c357t-f36d9b4bde78b6b886daf183f77e8d99b0d53b7d9db3148cd89ca16ff6e18323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0920-9964(93)90008-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8068050$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Joseph</creatorcontrib><creatorcontrib>Buchsbaum, Monte S.</creatorcontrib><creatorcontrib>Moy, Ken</creatorcontrib><creatorcontrib>Denlea, Nancy</creatorcontrib><creatorcontrib>Kesslak, Pat</creatorcontrib><creatorcontrib>Tseng, Henry</creatorcontrib><creatorcontrib>Plosnaj, Diane</creatorcontrib><creatorcontrib>Hetu, Martin</creatorcontrib><creatorcontrib>Potkin, Stephen</creatorcontrib><creatorcontrib>Bracha, Stefan</creatorcontrib><creatorcontrib>Cotman, Carl</creatorcontrib><title>Olfactory memory in unmedicated schizophrenics</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four normal subjects and twenty unmedicated schizophrenic patients were examined with two tests of olfactory function: the University of Pennsylvania Smell Identification Test (UPSIT) and a match-to-sample olfactory memory test. Results indicated that schizophrenics did poorly on both the UPSIT and the olfactory match-to-sample memory test relative to sex and age-matched controls. ANCOVA showed that the deficit in performance on the olfactory match-to-sample test was still present even when the variance due to the UPSIT was taken out of the analysis. Deficits in olfactory identification and olfactory memory are consistent with the concept that schizophrenics have dysfunctional limbic systems.</description><subject>Blood Glucose - metabolism</subject><subject>Brain - diagnostic imaging</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Deoxyglucose - metabolism</subject><subject>Discrimination Learning - physiology</subject><subject>Fluorodeoxyglucose F18</subject><subject>Frontal lobe</subject><subject>Frontal Lobe - diagnostic imaging</subject><subject>Frontal Lobe - physiopathology</subject><subject>Hippocampus</subject><subject>Humans</subject><subject>Mental Recall - physiology</subject><subject>Positron emission tomography</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Sensory Thresholds - physiology</subject><subject>Smell - physiology</subject><subject>Smell Identification Test</subject><subject>Tomography, Emission-Computed</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQKEr0cXUZDK5bQQp3qDQTfdhkpzQyFxqMhXq0zvTli5dncX_nXP4P4RuCZ4RTPgTVjnOlOLFg6KPCmMsM3GGxoQJmuUMq3M0PiGX6Cqlr54hDIsRGknMJWZ4jGbLype2a-NuWkM9jNBMt00NLtiyAzdNdh1-2806QhNsukYXvqwS3BznBK3eXlfzj2yxfP-cvywyS5noMk-5U6YwDoQ03EjJXemJpF4IkE4pgx2jRjjlDCWFtE4qWxLuPYeeyukE3R_ObmL7vYXU6TokC1VVNtBukxaMM5LvweIA2timFMHrTQx1GXeaYD1Y0oMCPSjQiuq9JS36tbvj_a3pq56Wjlr6_PmQQ9_xJ0DUyQZobG8lgu20a8P_D_4AmB12pQ</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Wu, Joseph</creator><creator>Buchsbaum, Monte S.</creator><creator>Moy, Ken</creator><creator>Denlea, Nancy</creator><creator>Kesslak, Pat</creator><creator>Tseng, Henry</creator><creator>Plosnaj, Diane</creator><creator>Hetu, Martin</creator><creator>Potkin, Stephen</creator><creator>Bracha, Stefan</creator><creator>Cotman, Carl</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Olfactory memory in unmedicated schizophrenics</title><author>Wu, Joseph ; Buchsbaum, Monte S. ; Moy, Ken ; Denlea, Nancy ; Kesslak, Pat ; Tseng, Henry ; Plosnaj, Diane ; Hetu, Martin ; Potkin, Stephen ; Bracha, Stefan ; Cotman, Carl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f36d9b4bde78b6b886daf183f77e8d99b0d53b7d9db3148cd89ca16ff6e18323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Blood Glucose - metabolism</topic><topic>Brain - diagnostic imaging</topic><topic>Deoxyglucose - analogs & derivatives</topic><topic>Deoxyglucose - metabolism</topic><topic>Discrimination Learning - physiology</topic><topic>Fluorodeoxyglucose F18</topic><topic>Frontal lobe</topic><topic>Frontal Lobe - diagnostic imaging</topic><topic>Frontal Lobe - physiopathology</topic><topic>Hippocampus</topic><topic>Humans</topic><topic>Mental Recall - physiology</topic><topic>Positron emission tomography</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Sensory Thresholds - physiology</topic><topic>Smell - physiology</topic><topic>Smell Identification Test</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Joseph</creatorcontrib><creatorcontrib>Buchsbaum, Monte S.</creatorcontrib><creatorcontrib>Moy, Ken</creatorcontrib><creatorcontrib>Denlea, Nancy</creatorcontrib><creatorcontrib>Kesslak, Pat</creatorcontrib><creatorcontrib>Tseng, Henry</creatorcontrib><creatorcontrib>Plosnaj, Diane</creatorcontrib><creatorcontrib>Hetu, Martin</creatorcontrib><creatorcontrib>Potkin, Stephen</creatorcontrib><creatorcontrib>Bracha, Stefan</creatorcontrib><creatorcontrib>Cotman, Carl</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Joseph</au><au>Buchsbaum, Monte S.</au><au>Moy, Ken</au><au>Denlea, Nancy</au><au>Kesslak, Pat</au><au>Tseng, Henry</au><au>Plosnaj, Diane</au><au>Hetu, Martin</au><au>Potkin, Stephen</au><au>Bracha, Stefan</au><au>Cotman, Carl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Olfactory memory in unmedicated schizophrenics</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>9</volume><issue>1</issue><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Previous studies have indicated that schizophrenic patients have olfactory deficits. The question as to whether olfactory deficits are due to chronic effects of medication has not been addressed. This is the first paper to report that never-medicated schizophrenic patients also have olfactory deficits. Twenty four normal subjects and twenty unmedicated schizophrenic patients were examined with two tests of olfactory function: the University of Pennsylvania Smell Identification Test (UPSIT) and a match-to-sample olfactory memory test. Results indicated that schizophrenics did poorly on both the UPSIT and the olfactory match-to-sample memory test relative to sex and age-matched controls. ANCOVA showed that the deficit in performance on the olfactory match-to-sample test was still present even when the variance due to the UPSIT was taken out of the analysis. Deficits in olfactory identification and olfactory memory are consistent with the concept that schizophrenics have dysfunctional limbic systems.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>8068050</pmid><doi>10.1016/0920-9964(93)90008-7</doi><tpages>7</tpages></addata></record> |
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| ispartof | Schizophrenia research, 1993-03, Vol.9 (1), p.41-47 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Blood Glucose - metabolism Brain - diagnostic imaging Deoxyglucose - analogs & derivatives Deoxyglucose - metabolism Discrimination Learning - physiology Fluorodeoxyglucose F18 Frontal lobe Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology Hippocampus Humans Mental Recall - physiology Positron emission tomography Schizophrenia - diagnostic imaging Schizophrenia - physiopathology Schizophrenic Psychology Sensory Thresholds - physiology Smell - physiology Smell Identification Test Tomography, Emission-Computed |
| title | Olfactory memory in unmedicated schizophrenics |
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