Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients
Serum thrombomodulin (sTM) is an endothelial cell marker which would reflect the endothelial damage. In order to examine whether some antiplatelet agents decrease the endothelial damage in diabetic patients, sTM concentrations were measured by enzyme-linked immunosorbant assay before and after oral...
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| Veröffentlicht in: | Thrombosis research 1993, Vol.69 (1), p.153-158 |
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| container_title | Thrombosis research |
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| creator | Tani, Nagayuki Hada, Kumiko Kitami, Akemi Nakano, Masahiko Takahashi, Hoyu Ito, Seiki Sato, Iwao Shibata, Akira |
| description | Serum thrombomodulin (sTM) is an endothelial cell marker which would reflect the endothelial damage. In order to examine whether some antiplatelet agents decrease the endothelial damage in diabetic patients, sTM concentrations were measured by enzyme-linked immunosorbant assay before and after oral administration of a daily 100 mg of cilostazol for 4 weeks in 9 diabetics or a daily 81 mg of acetyl salicylic acids (ASA) for 4 weeks in 8 diabetics. Basal concentrations of sTM were elevated in most of these patients as compared with healthy subjects. The sTM concentrations were decreased after administration of cilostazol from 28.1 ± 7.1 ng/ml to 23.6 ± 5.4 ng/ml (p |
| doi_str_mv | 10.1016/0049-3848(93)90012-D |
| format | Article |
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In order to examine whether some antiplatelet agents decrease the endothelial damage in diabetic patients, sTM concentrations were measured by enzyme-linked immunosorbant assay before and after oral administration of a daily 100 mg of cilostazol for 4 weeks in 9 diabetics or a daily 81 mg of acetyl salicylic acids (ASA) for 4 weeks in 8 diabetics. Basal concentrations of sTM were elevated in most of these patients as compared with healthy subjects. The sTM concentrations were decreased after administration of cilostazol from 28.1 ± 7.1 ng/ml to 23.6 ± 5.4 ng/ml (p<0.01), and after ASA from 30.7 ± 10.9 ng/ml to 27.9 ± 11.6 ng/ml (p<0.05). These results suggest that such drugs can decrease the endothelial damage, resulting in the reduced risk of diabetic vascular complications.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(93)90012-D</identifier><identifier>PMID: 8385368</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>acetyl salicylic acid ; Aged ; Aspirin - pharmacology ; Associated diseases and complications ; Biological and medical sciences ; Cilostazol ; Diabetes Mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - drug therapy ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium, Vascular - drug effects ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Receptors, Cell Surface - analysis ; Receptors, Thrombin ; Tetrazoles - pharmacology ; thrombomodulin</subject><ispartof>Thrombosis research, 1993, Vol.69 (1), p.153-158</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5691a9bbbd5f9fb10bd1f56b2cf1670eae5ef86b790ddf86026bc0ea8059d9543</citedby><cites>FETCH-LOGICAL-c386t-5691a9bbbd5f9fb10bd1f56b2cf1670eae5ef86b790ddf86026bc0ea8059d9543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/004938489390012D$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4661135$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8385368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tani, Nagayuki</creatorcontrib><creatorcontrib>Hada, Kumiko</creatorcontrib><creatorcontrib>Kitami, Akemi</creatorcontrib><creatorcontrib>Nakano, Masahiko</creatorcontrib><creatorcontrib>Takahashi, Hoyu</creatorcontrib><creatorcontrib>Ito, Seiki</creatorcontrib><creatorcontrib>Sato, Iwao</creatorcontrib><creatorcontrib>Shibata, Akira</creatorcontrib><title>Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Serum thrombomodulin (sTM) is an endothelial cell marker which would reflect the endothelial damage. In order to examine whether some antiplatelet agents decrease the endothelial damage in diabetic patients, sTM concentrations were measured by enzyme-linked immunosorbant assay before and after oral administration of a daily 100 mg of cilostazol for 4 weeks in 9 diabetics or a daily 81 mg of acetyl salicylic acids (ASA) for 4 weeks in 8 diabetics. Basal concentrations of sTM were elevated in most of these patients as compared with healthy subjects. The sTM concentrations were decreased after administration of cilostazol from 28.1 ± 7.1 ng/ml to 23.6 ± 5.4 ng/ml (p<0.01), and after ASA from 30.7 ± 10.9 ng/ml to 27.9 ± 11.6 ng/ml (p<0.05). These results suggest that such drugs can decrease the endothelial damage, resulting in the reduced risk of diabetic vascular complications.</description><subject>acetyl salicylic acid</subject><subject>Aged</subject><subject>Aspirin - pharmacology</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Cilostazol</subject><subject>Diabetes Mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - drug therapy</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Receptors, Cell Surface - analysis</subject><subject>Receptors, Thrombin</subject><subject>Tetrazoles - pharmacology</subject><subject>thrombomodulin</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModVv9Bwq5EKkXU5OZSSa5KUhb20LBG70O-cRIZrImGWH99Z51170UEhLe85xDeILQG0quKKH8IyGj7AYxiks5fJCE0L67fYY2VEyy68epf442J-QlOq_1BzATlewMnYlBsIGLDdrdheBtqzgHrK1vu4SrTtHuYEMQHdaLwzamXJv-nRPWbo5LrK3oFvOCYVVf1hm37yXPJs_ZrSku2ObF-uUfBYGL2vgGQ7cQQaW-Qi-CTtW_Pp4X6Nvnu683D93Tl_vHm09PnR0Ebx3jkmppjHEsyGAoMY4Gxk1vA-UT8dozHwQ3kyTOwYX03FiIBWHSSTYOF-j9Ye625J-rr03NsVqfkl58XquaGB8FFxOA4wG0JddafFDbEmdddooStTeu9jrVXqeSg_prXN1C29vj_NXM3p2ajoqh_u5Y19XqFIpebKwnbOSc0oEBdn3APLj4FX1R1YIn610s8EHK5fj_d_wBqSOgWg</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Tani, Nagayuki</creator><creator>Hada, Kumiko</creator><creator>Kitami, Akemi</creator><creator>Nakano, Masahiko</creator><creator>Takahashi, Hoyu</creator><creator>Ito, Seiki</creator><creator>Sato, Iwao</creator><creator>Shibata, Akira</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients</title><author>Tani, Nagayuki ; Hada, Kumiko ; Kitami, Akemi ; Nakano, Masahiko ; Takahashi, Hoyu ; Ito, Seiki ; Sato, Iwao ; Shibata, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5691a9bbbd5f9fb10bd1f56b2cf1670eae5ef86b790ddf86026bc0ea8059d9543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>acetyl salicylic acid</topic><topic>Aged</topic><topic>Aspirin - pharmacology</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Cilostazol</topic><topic>Diabetes Mellitus</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - drug therapy</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Receptors, Cell Surface - analysis</topic><topic>Receptors, Thrombin</topic><topic>Tetrazoles - pharmacology</topic><topic>thrombomodulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tani, Nagayuki</creatorcontrib><creatorcontrib>Hada, Kumiko</creatorcontrib><creatorcontrib>Kitami, Akemi</creatorcontrib><creatorcontrib>Nakano, Masahiko</creatorcontrib><creatorcontrib>Takahashi, Hoyu</creatorcontrib><creatorcontrib>Ito, Seiki</creatorcontrib><creatorcontrib>Sato, Iwao</creatorcontrib><creatorcontrib>Shibata, Akira</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tani, Nagayuki</au><au>Hada, Kumiko</au><au>Kitami, Akemi</au><au>Nakano, Masahiko</au><au>Takahashi, Hoyu</au><au>Ito, Seiki</au><au>Sato, Iwao</au><au>Shibata, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1993</date><risdate>1993</risdate><volume>69</volume><issue>1</issue><spage>153</spage><epage>158</epage><pages>153-158</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Serum thrombomodulin (sTM) is an endothelial cell marker which would reflect the endothelial damage. In order to examine whether some antiplatelet agents decrease the endothelial damage in diabetic patients, sTM concentrations were measured by enzyme-linked immunosorbant assay before and after oral administration of a daily 100 mg of cilostazol for 4 weeks in 9 diabetics or a daily 81 mg of acetyl salicylic acids (ASA) for 4 weeks in 8 diabetics. Basal concentrations of sTM were elevated in most of these patients as compared with healthy subjects. The sTM concentrations were decreased after administration of cilostazol from 28.1 ± 7.1 ng/ml to 23.6 ± 5.4 ng/ml (p<0.01), and after ASA from 30.7 ± 10.9 ng/ml to 27.9 ± 11.6 ng/ml (p<0.05). These results suggest that such drugs can decrease the endothelial damage, resulting in the reduced risk of diabetic vascular complications.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>8385368</pmid><doi>10.1016/0049-3848(93)90012-D</doi><tpages>6</tpages></addata></record> |
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| subjects | acetyl salicylic acid Aged Aspirin - pharmacology Associated diseases and complications Biological and medical sciences Cilostazol Diabetes Mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Female Humans Male Medical sciences Middle Aged Receptors, Cell Surface - analysis Receptors, Thrombin Tetrazoles - pharmacology thrombomodulin |
| title | Effects of acetyl salicylic acid and cilostazol administration on serum thrombomodulin concentration in diabetic patients |
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