Analogues of Arachidonic Acid Used To Evaluate Structural Determinants of Prostaglandin Receptor and Enzyme Specificities

Using 14 C-labeled fatty acids (19:4 ω6, 19:4 ω5, 21:4 ω6, and 21:4 ω7), radiochemical evidence of the formation of α-nor-, ω-nor-, α-homo-, and ω-homoprostaglandin endoperoxides (PGH 2 ), prostacyclins (PGI 2 ), and thromboxanes (TA 2 ) was obtained. Investigation of the biological activiti...

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Veröffentlicht in:	Molecular pharmacology 1981-03, Vol.19 (2), p.242-247
Hauptverfasser:	LeDuc, L E, Wyche, A A, Sprecher, H, Sankarappe, S K, Needleman, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aorta - metabolism Arachidonic Acids Humans In Vitro Techniques Microsomes - metabolism Muscle, Smooth - drug effects Muscle, Smooth, Vascular - drug effects Platelet Aggregation - drug effects Prostaglandin Endoperoxides - pharmacology Prostaglandins - metabolism Receptors, Cell Surface - metabolism Receptors, Prostaglandin - drug effects Receptors, Prostaglandin - metabolism Substrate Specificity Thromboxanes - pharmacology
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