Modulation of Neuronal Migration by NMDA Receptors
The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is essential for neuronal differentiation and establishment or elimination of synapses in a developing brain. The activity of the NMDA receptor has now been shown to also regulate the migration of granule cells in slice preparations o...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1993-04, Vol.260 (5104), p.95-97 |
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| creator | Komuro, Hitoshi Rakic, Pasko |
| description | The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is essential for neuronal differentiation and establishment or elimination of synapses in a developing brain. The activity of the NMDA receptor has now been shown to also regulate the migration of granule cells in slice preparations of the developing mouse cerebellum. First, blockade of NMDA receptors by specific antagonists resulted in the curtailment of cell migration. Second, enhancement of NMDA receptor activity by the removal of magnesium or by the application of glycine increased the rate of cell movement. Third, increase of endogenous extracellular glutamate by inhibition of its uptake accelerated the rate of cell migration. These results suggest that NMDA receptors may play an early role in the regulation of calcium-dependent cell migration before neurons reach their targets and form synaptic contacts. |
| doi_str_mv | 10.1126/science.8096653 |
| format | Article |
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The activity of the NMDA receptor has now been shown to also regulate the migration of granule cells in slice preparations of the developing mouse cerebellum. First, blockade of NMDA receptors by specific antagonists resulted in the curtailment of cell migration. Second, enhancement of NMDA receptor activity by the removal of magnesium or by the application of glycine increased the rate of cell movement. Third, increase of endogenous extracellular glutamate by inhibition of its uptake accelerated the rate of cell migration. 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Psychology ; Genes ; Glutamates - pharmacology ; Glutamic Acid ; Glycine - pharmacology ; Magnesium - pharmacology ; Methyl aspartate ; Mice ; Migration ; N methyl D aspartate receptors ; N-methyl-D-aspartate ; N-Methylaspartate - pharmacology ; Neural receptors ; Neurons ; Neurons - cytology ; Neuroscience ; Physiological aspects ; Receptors ; Receptors, GABA-A - physiology ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - physiology ; Rodents ; Statistical significance ; Synapses ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 1993-04, Vol.260 (5104), p.95-97</ispartof><rights>Copyright 1993 American Association for the Advancement of Science</rights><rights>1993 INIST-CNRS</rights><rights>COPYRIGHT 1993 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1993 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Apr 2, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c739t-6831fd01405f90a07da4559453a7165dd69e0847636b98c58f4561eff15c46af3</citedby><cites>FETCH-LOGICAL-c739t-6831fd01405f90a07da4559453a7165dd69e0847636b98c58f4561eff15c46af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2881130$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2881130$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4690761$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8096653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komuro, Hitoshi</creatorcontrib><creatorcontrib>Rakic, Pasko</creatorcontrib><title>Modulation of Neuronal Migration by NMDA Receptors</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>The N-methyl-D-aspartate (NMDA) subtype of the glutamate receptor is essential for neuronal differentiation and establishment or elimination of synapses in a developing brain. 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The activity of the NMDA receptor has now been shown to also regulate the migration of granule cells in slice preparations of the developing mouse cerebellum. First, blockade of NMDA receptors by specific antagonists resulted in the curtailment of cell migration. Second, enhancement of NMDA receptor activity by the removal of magnesium or by the application of glycine increased the rate of cell movement. Third, increase of endogenous extracellular glutamate by inhibition of its uptake accelerated the rate of cell migration. These results suggest that NMDA receptors may play an early role in the regulation of calcium-dependent cell migration before neurons reach their targets and form synaptic contacts.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8096653</pmid><doi>10.1126/science.8096653</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1993-04, Vol.260 (5104), p.95-97 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75645376 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | 2-Amino-5-phosphonovalerate - pharmacology 4-Chloromercuribenzenesulfonate - pharmacology Animals Biochemistry Biological and medical sciences Brain Calcium - metabolism Cell migration Cell motility Cell Movement - physiology Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum Cerebellum - cytology Cerebellum - drug effects Cultured cells Dizocilpine Maleate - pharmacology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Fundamental and applied biological sciences. Psychology Genes Glutamates - pharmacology Glutamic Acid Glycine - pharmacology Magnesium - pharmacology Methyl aspartate Mice Migration N methyl D aspartate receptors N-methyl-D-aspartate N-Methylaspartate - pharmacology Neural receptors Neurons Neurons - cytology Neuroscience Physiological aspects Receptors Receptors, GABA-A - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Rodents Statistical significance Synapses Vertebrates: nervous system and sense organs |
| title | Modulation of Neuronal Migration by NMDA Receptors |
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