In situ capture of mu-calpain activation in platelets

In situ detection of calpain activation in intact cells has not been possible to date. Here we present the first direct evidence, employing a novel approach, that mu-calpain is rapidly activated at cell membranes in platelets upon a rise in intracellular calcium concentration. Immunoelectron microsc...

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Veröffentlicht in:	The Journal of biological chemistry 1993-04, Vol.268 (10), p.7422-7426
Hauptverfasser:	SAIDO, T. C, SUZUKI, H, YAMAZAKI, H, TANOUE, K, SUZUKI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Analytical, structural and metabolic biochemistry Biological and medical sciences Blood Platelets - enzymology Blood Platelets - ultrastructure Blotting, Western calcium calpain Calpain - metabolism electron microscopy Enzyme Activation Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Humans Hydrolases man membranes Microscopy, Immunoelectron platelets
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