The induction of early response genes in rat smooth muscle cells by PDGF-AA is not sufficient to stimulate DNA-synthesis

The effect of the three platelet-derived growth factor (PDGF) isoforms AA, AB and BB on the induction of the early growth response genes c- fos, egr-1 and c- myc mRNA in vascular smooth muscle cells from rat was compared with their respective mitogenic potency. The three PDGF isoforms strongly stimu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEBS letters 1993-03, Vol.319 (3), p.221-224
Hauptverfasser:	Sachinidis, Agapios, Schulte, Kerstin, Ko, Yon, Meyer zu Brickwedde, Maria Katharina, Hoppe, Viviane, Hoppe, Jürgen, Vetter, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences c- fos c- myc Cell physiology Cells, Cultured DMEM, Dulbecco's modified Eagle's medium DNA - biosynthesis DNA-Binding Proteins - genetics Early Growth Response Protein 1 egr-1 egr-1, early growth response gene-1 Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genes, fos Genes, myc Immediate-Early Proteins In Vitro Techniques InsP3, inositoltrisphosphate Molecular and cellular biology Muscle, Smooth, Vascular - physiology PC, phosphatidylcholine PDGF, platelet-derived growth factor Phosphotyrosine PKC, protein kinase C Platelet-derived growth factor (PDGF) isoform Platelet-Derived Growth Factor - pharmacology PLC-γ, phospholipase Cγ Rats Rats, Inbred WKY Receptor autophosphorylation Receptors, Platelet-Derived Growth Factor - physiology Recombinant Proteins - pharmacology Responses to growth factors, tumor promotors, other factors SH2, src-kinase homologous region 2 Signal Transduction Transcription Factors - genetics Tyrosine - analogs & derivatives Tyrosine - metabolism VSMC, vascular smooth muscle cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!