Effect of Maternal Zinc Deficiency or Food Restriction on Rat Fetal Pancreas. I. Procarboxypeptidase A and Chymotrypsinogen
Maternal zinc deficiency lowered the protein, zinc and zymogen content of the day 19 rat fetal pancreas. Pregnant Sprague-Dawley rats were fed a zinc-deficient diet (0.4 ± 0.1 ppm zinc) ad libitum or a zinc-supplemented control diet (100 ppm zinc) either ad libitum or with restricted intake. At day...
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| Veröffentlicht in: | The Journal of nutrition 1981-05, Vol.111 (5), p.858-868 |
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| creator | Robinson, Leann K. Hurley, Lucille S. |
| description | Maternal zinc deficiency lowered the protein, zinc and zymogen content of the day 19 rat fetal pancreas. Pregnant Sprague-Dawley rats were fed a zinc-deficient diet (0.4 ± 0.1 ppm zinc) ad libitum or a zinc-supplemented control diet (100 ppm zinc) either ad libitum or with restricted intake. At day 19 of pregnancy, the pancreata from zinc-deficient fetuses contained 50% less zinc and 15% less cellular protein than did fetal pancreas from normal or restricted intake controls, although DNA content was normal. Zymogen granulation of pancreatic acinar cells from zinc-deficient fetuses was decreased. The two major proteolytic zymogens of the rat fetal pancreas—procarboxypeptidase A, a zinc metalloprotein, and chymotrypsinogen—were each 30% lower per cell in zinc-deficient fetuses than in controls. Zinc-deficient fetuses taken from large litters of seven or more young per litter had lower levels of procarboxypeptidase A and chymotrypsinogen in the pancreata than did fetuses taken from smaller litters. The results suggest that exocrine zymogen accumulation is lower than normal in the pancreata of zinc-deficient fetuses, irrespective of the zinc dependency of the enzyme proteins involved.
pancreatic development zinc deficiency procarboxypeptidase A chymotrypsinogen |
| doi_str_mv | 10.1093/jn/111.5.858 |
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pancreatic development zinc deficiency procarboxypeptidase A chymotrypsinogen</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/111.5.858</identifier><identifier>PMID: 7229736</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Carboxypeptidases - metabolism ; Carboxypeptidases A ; Chymotrypsinogen - metabolism ; Diet ; Energy Intake ; Enzyme Precursors - metabolism ; Female ; Food Deprivation - physiology ; Maternal-Fetal Exchange ; Pancreas - embryology ; Pancreas - enzymology ; Pregnancy ; Rats ; Zinc - deficiency ; Zinc - metabolism</subject><ispartof>The Journal of nutrition, 1981-05, Vol.111 (5), p.858-868</ispartof><rights>1981 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3098-eb03ab58dac9f8616d02d1f50585d563d845411b84696f0010dea63491af582e3</citedby><cites>FETCH-LOGICAL-c3098-eb03ab58dac9f8616d02d1f50585d563d845411b84696f0010dea63491af582e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7229736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, Leann K.</creatorcontrib><creatorcontrib>Hurley, Lucille S.</creatorcontrib><creatorcontrib>United States. Health Services Administration. Bureau of Community Health Services</creatorcontrib><title>Effect of Maternal Zinc Deficiency or Food Restriction on Rat Fetal Pancreas. I. Procarboxypeptidase A and Chymotrypsinogen</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Maternal zinc deficiency lowered the protein, zinc and zymogen content of the day 19 rat fetal pancreas. Pregnant Sprague-Dawley rats were fed a zinc-deficient diet (0.4 ± 0.1 ppm zinc) ad libitum or a zinc-supplemented control diet (100 ppm zinc) either ad libitum or with restricted intake. At day 19 of pregnancy, the pancreata from zinc-deficient fetuses contained 50% less zinc and 15% less cellular protein than did fetal pancreas from normal or restricted intake controls, although DNA content was normal. Zymogen granulation of pancreatic acinar cells from zinc-deficient fetuses was decreased. The two major proteolytic zymogens of the rat fetal pancreas—procarboxypeptidase A, a zinc metalloprotein, and chymotrypsinogen—were each 30% lower per cell in zinc-deficient fetuses than in controls. Zinc-deficient fetuses taken from large litters of seven or more young per litter had lower levels of procarboxypeptidase A and chymotrypsinogen in the pancreata than did fetuses taken from smaller litters. The results suggest that exocrine zymogen accumulation is lower than normal in the pancreata of zinc-deficient fetuses, irrespective of the zinc dependency of the enzyme proteins involved.
pancreatic development zinc deficiency procarboxypeptidase A chymotrypsinogen</description><subject>Animals</subject><subject>Carboxypeptidases - metabolism</subject><subject>Carboxypeptidases A</subject><subject>Chymotrypsinogen - metabolism</subject><subject>Diet</subject><subject>Energy Intake</subject><subject>Enzyme Precursors - metabolism</subject><subject>Female</subject><subject>Food Deprivation - physiology</subject><subject>Maternal-Fetal Exchange</subject><subject>Pancreas - embryology</subject><subject>Pancreas - enzymology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Zinc - deficiency</subject><subject>Zinc - metabolism</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkcFvFCEUh4nR1LV686rh5MmZwjAwcGzWrjapsan24oUw8KhsdmGEWePEf150N55MSN7hfe-9_D4QeklJS4liF9t4QSlteSu5fIRWlPe0EZSQx2hFSNc1jArxFD0rZUsIob2SZ-hs6Do1MLFCv668Bzvj5PFHM0OOZoe_hmjxO_DBBoh2wSnjTUoO30GZc7BzSBHXd2dmvIG5DtyaaDOY0uLrFt_mZE0e089lgmkOzhTAl9hEh9ffln2a8zKVENMDxOfoiTe7Ai9O9Rzdb66-rD80N5_eX68vbxrLiJINjISZkUtnrPJSUOFI56jnhEvuuGBO9jUyHWUvlPA1InFgBOsVNZ7LDtg5enPcO-X0_VBD6H0oFnY7EyEdih646CkfZAXfHkGbUykZvJ5y2Ju8aEr0H9d6G3V1rbmuriv-6rT3MO7B_YNPcmv_9bHvTdLmIYei7z9TJSkRismBV0AcAajpfwTIuvxVDi7k-inapfD_y78BtPOVPg</recordid><startdate>198105</startdate><enddate>198105</enddate><creator>Robinson, Leann K.</creator><creator>Hurley, Lucille S.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198105</creationdate><title>Effect of Maternal Zinc Deficiency or Food Restriction on Rat Fetal Pancreas. 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Procarboxypeptidase A and Chymotrypsinogen</title><author>Robinson, Leann K. ; Hurley, Lucille S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3098-eb03ab58dac9f8616d02d1f50585d563d845411b84696f0010dea63491af582e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Carboxypeptidases - metabolism</topic><topic>Carboxypeptidases A</topic><topic>Chymotrypsinogen - metabolism</topic><topic>Diet</topic><topic>Energy Intake</topic><topic>Enzyme Precursors - metabolism</topic><topic>Female</topic><topic>Food Deprivation - physiology</topic><topic>Maternal-Fetal Exchange</topic><topic>Pancreas - embryology</topic><topic>Pancreas - enzymology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Zinc - deficiency</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, Leann K.</creatorcontrib><creatorcontrib>Hurley, Lucille S.</creatorcontrib><creatorcontrib>United States. Health Services Administration. Bureau of Community Health Services</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, Leann K.</au><au>Hurley, Lucille S.</au><aucorp>United States. Health Services Administration. Bureau of Community Health Services</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Maternal Zinc Deficiency or Food Restriction on Rat Fetal Pancreas. I. Procarboxypeptidase A and Chymotrypsinogen</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1981-05</date><risdate>1981</risdate><volume>111</volume><issue>5</issue><spage>858</spage><epage>868</epage><pages>858-868</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Maternal zinc deficiency lowered the protein, zinc and zymogen content of the day 19 rat fetal pancreas. Pregnant Sprague-Dawley rats were fed a zinc-deficient diet (0.4 ± 0.1 ppm zinc) ad libitum or a zinc-supplemented control diet (100 ppm zinc) either ad libitum or with restricted intake. At day 19 of pregnancy, the pancreata from zinc-deficient fetuses contained 50% less zinc and 15% less cellular protein than did fetal pancreas from normal or restricted intake controls, although DNA content was normal. Zymogen granulation of pancreatic acinar cells from zinc-deficient fetuses was decreased. The two major proteolytic zymogens of the rat fetal pancreas—procarboxypeptidase A, a zinc metalloprotein, and chymotrypsinogen—were each 30% lower per cell in zinc-deficient fetuses than in controls. Zinc-deficient fetuses taken from large litters of seven or more young per litter had lower levels of procarboxypeptidase A and chymotrypsinogen in the pancreata than did fetuses taken from smaller litters. The results suggest that exocrine zymogen accumulation is lower than normal in the pancreata of zinc-deficient fetuses, irrespective of the zinc dependency of the enzyme proteins involved.
pancreatic development zinc deficiency procarboxypeptidase A chymotrypsinogen</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7229736</pmid><doi>10.1093/jn/111.5.858</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1981-05, Vol.111 (5), p.858-868 |
| issn | 0022-3166 1541-6100 |
| language | eng |
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| subjects | Animals Carboxypeptidases - metabolism Carboxypeptidases A Chymotrypsinogen - metabolism Diet Energy Intake Enzyme Precursors - metabolism Female Food Deprivation - physiology Maternal-Fetal Exchange Pancreas - embryology Pancreas - enzymology Pregnancy Rats Zinc - deficiency Zinc - metabolism |
| title | Effect of Maternal Zinc Deficiency or Food Restriction on Rat Fetal Pancreas. I. Procarboxypeptidase A and Chymotrypsinogen |
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