A Method of Dynamic Analysis of Iodine-123-Metaiodobenzylguanidine Scintigrams in Cardiac Mechanical Overload Hypertrophy and Failure
Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload....
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| Veröffentlicht in: | The Journal of nuclear medicine (1978) 1993-04, Vol.34 (4), p.589-600 |
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| container_end_page | 600 |
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| container_issue | 4 |
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| container_title | The Journal of nuclear medicine (1978) |
| container_volume | 34 |
| creator | Rabinovitch, Mark A Rose, Colin P Schwab, Andreas J Fitchett, David H Honos, George N Stewart, James A Chen, Luis F Castilla, Elia P Gomez, Alvaro A Abrahamowicz, Michal |
| description | Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yield a quantitative index of myocardial sympathetic neuronal function in this condition. We performed serial 123I-MIBG scintigraphy in 33 volunteers, 10 orthotopic cardiac transplant recipients and 26 patients with chronic mechanical overload of the left ventricle. We constructed a compartmental model in which total heart activity represents the sum of cardiac sympathetic vesicular and cytosolic pools. Patients with antecedent mechanical overload heart failure or myocardial dysfunction had accelerated myocardial egress of tracer that we ascribed to a specific impairment in vesicular storage rather than to a more rapid turnover of an intact vesicular pool. |
| format | Article |
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We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yield a quantitative index of myocardial sympathetic neuronal function in this condition. We performed serial 123I-MIBG scintigraphy in 33 volunteers, 10 orthotopic cardiac transplant recipients and 26 patients with chronic mechanical overload of the left ventricle. We constructed a compartmental model in which total heart activity represents the sum of cardiac sympathetic vesicular and cytosolic pools. Patients with antecedent mechanical overload heart failure or myocardial dysfunction had accelerated myocardial egress of tracer that we ascribed to a specific impairment in vesicular storage rather than to a more rapid turnover of an intact vesicular pool.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 8455075</identifier><language>eng</language><publisher>United States: Soc Nuclear Med</publisher><subject>3-Iodobenzylguanidine ; Clonidine - therapeutic use ; Female ; Heart - diagnostic imaging ; Heart - innervation ; Heart Failure - diagnostic imaging ; Heart Transplantation - diagnostic imaging ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Image Processing, Computer-Assisted ; Iodine Radioisotopes ; Iodobenzenes ; Male ; Middle Aged ; Premedication ; Radionuclide Imaging ; Reproducibility of Results ; Sympatholytics</subject><ispartof>The Journal of nuclear medicine (1978), 1993-04, Vol.34 (4), p.589-600</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8455075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rabinovitch, Mark A</creatorcontrib><creatorcontrib>Rose, Colin P</creatorcontrib><creatorcontrib>Schwab, Andreas J</creatorcontrib><creatorcontrib>Fitchett, David H</creatorcontrib><creatorcontrib>Honos, George N</creatorcontrib><creatorcontrib>Stewart, James A</creatorcontrib><creatorcontrib>Chen, Luis F</creatorcontrib><creatorcontrib>Castilla, Elia P</creatorcontrib><creatorcontrib>Gomez, Alvaro A</creatorcontrib><creatorcontrib>Abrahamowicz, Michal</creatorcontrib><title>A Method of Dynamic Analysis of Iodine-123-Metaiodobenzylguanidine Scintigrams in Cardiac Mechanical Overload Hypertrophy and Failure</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>Cardiac sympathetic neuronal degeneration accompanies mechanical overload heart failure. We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yield a quantitative index of myocardial sympathetic neuronal function in this condition. We performed serial 123I-MIBG scintigraphy in 33 volunteers, 10 orthotopic cardiac transplant recipients and 26 patients with chronic mechanical overload of the left ventricle. We constructed a compartmental model in which total heart activity represents the sum of cardiac sympathetic vesicular and cytosolic pools. Patients with antecedent mechanical overload heart failure or myocardial dysfunction had accelerated myocardial egress of tracer that we ascribed to a specific impairment in vesicular storage rather than to a more rapid turnover of an intact vesicular pool.</description><subject>3-Iodobenzylguanidine</subject><subject>Clonidine - therapeutic use</subject><subject>Female</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - innervation</subject><subject>Heart Failure - diagnostic imaging</subject><subject>Heart Transplantation - diagnostic imaging</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Image Processing, Computer-Assisted</subject><subject>Iodine Radioisotopes</subject><subject>Iodobenzenes</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Premedication</subject><subject>Radionuclide Imaging</subject><subject>Reproducibility of Results</subject><subject>Sympatholytics</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AURYMoWqs_QZiVu0Cm85UsS7VaqHSh-_CSeWlGJjN1JlHi3v9tigVXF-49nMU9S2ZUMJEKKdV5MsuopKkQmbhKrmN8z7JM5nl-mVzmfGqVmCU_S_KCfes18Q15GB10piZLB3aMJh67jdfGYUoXLJ1AMF77Ct33aPcDOHPcyGttXG_2AbpIjCMrCNpAPXnrdkJqsGT3icF60OR5PGDogz-0IwGnyRqMHQLeJBcN2Ii3p5wnb-vHt9Vzut09bVbLbdoumOrTuioWyIFKxUDxRjVNwxQqzfMmpwuZIVSaouYUlK7yrCikQi6lUEILxQo2T-7_tIfgPwaMfdmZWKO14NAPsVRCcpoVbALvTuBQdajLQzAdhLE83fYvas2-_TIBSzfUFiEc4XfXMV7yUuQF-wUZ1HkP</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>Rabinovitch, Mark A</creator><creator>Rose, Colin P</creator><creator>Schwab, Andreas J</creator><creator>Fitchett, David H</creator><creator>Honos, George N</creator><creator>Stewart, James A</creator><creator>Chen, Luis F</creator><creator>Castilla, Elia P</creator><creator>Gomez, Alvaro A</creator><creator>Abrahamowicz, Michal</creator><general>Soc Nuclear Med</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19930401</creationdate><title>A Method of Dynamic Analysis of Iodine-123-Metaiodobenzylguanidine Scintigrams in Cardiac Mechanical Overload Hypertrophy and Failure</title><author>Rabinovitch, Mark A ; 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We hypothesized that sympathetic nerve and myocyte failure share a common etiology and that 123I-metaiodobenzylguanidine (MIBG) might provide a precise method of detecting failure in chronic mechanical overload. Our aim was to develop a method for the dynamic analysis of 123I-MIBG scintigrams which could yield a quantitative index of myocardial sympathetic neuronal function in this condition. We performed serial 123I-MIBG scintigraphy in 33 volunteers, 10 orthotopic cardiac transplant recipients and 26 patients with chronic mechanical overload of the left ventricle. We constructed a compartmental model in which total heart activity represents the sum of cardiac sympathetic vesicular and cytosolic pools. Patients with antecedent mechanical overload heart failure or myocardial dysfunction had accelerated myocardial egress of tracer that we ascribed to a specific impairment in vesicular storage rather than to a more rapid turnover of an intact vesicular pool.</abstract><cop>United States</cop><pub>Soc Nuclear Med</pub><pmid>8455075</pmid><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0161-5505 |
| ispartof | The Journal of nuclear medicine (1978), 1993-04, Vol.34 (4), p.589-600 |
| issn | 0161-5505 1535-5667 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 3-Iodobenzylguanidine Clonidine - therapeutic use Female Heart - diagnostic imaging Heart - innervation Heart Failure - diagnostic imaging Heart Transplantation - diagnostic imaging Humans Hypertrophy, Left Ventricular - diagnostic imaging Image Processing, Computer-Assisted Iodine Radioisotopes Iodobenzenes Male Middle Aged Premedication Radionuclide Imaging Reproducibility of Results Sympatholytics |
| title | A Method of Dynamic Analysis of Iodine-123-Metaiodobenzylguanidine Scintigrams in Cardiac Mechanical Overload Hypertrophy and Failure |
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