Effect of embryonic hippocampal transplantation in amygdaloid kindled rat
Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocort...
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| Veröffentlicht in: | Brain research 1993-02, Vol.603 (1), p.143-147 |
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| creator | Miyamoto, Osamu Itano, Toshifumi Yamamoto, Yoshitaka Tokuda, Masaaki Matsui, Hideki Janjua, Najma A. Suwaki, Hiroshi Okada, Yasushi Murakami, Tetuhide H. Negi, Tetsuro Nakahara, Sukita Hatase, Osamu |
| description | Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies. |
| doi_str_mv | 10.1016/0006-8993(93)91312-G |
| format | Article |
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A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(93)91312-G</identifier><identifier>PMID: 8453471</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Amygdala - physiology ; Animals ; Biological and medical sciences ; Brain Tissue Transplantation - physiology ; Cerebral Cortex - cytology ; Cerebral Cortex - physiology ; Cerebral Cortex - transplantation ; Epilepsy ; Female ; Fetal Tissue Transplantation - physiology ; Hippocampus ; Hippocampus - anatomy & histology ; Hippocampus - embryology ; Hippocampus - transplantation ; Kindling ; Kindling, Neurologic - physiology ; Male ; Medical sciences ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Transplantation</subject><ispartof>Brain research, 1993-02, Vol.603 (1), p.143-147</ispartof><rights>1993 Elsevier Science Publishers B.V. All rights reserved</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-c68e5b3cb5dad6d68053c15281a5646c0631424006d5dfa3a9fd5b14d47a3ffa3</citedby><cites>FETCH-LOGICAL-c483t-c68e5b3cb5dad6d68053c15281a5646c0631424006d5dfa3a9fd5b14d47a3ffa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000689939391312G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4557438$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8453471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyamoto, Osamu</creatorcontrib><creatorcontrib>Itano, Toshifumi</creatorcontrib><creatorcontrib>Yamamoto, Yoshitaka</creatorcontrib><creatorcontrib>Tokuda, Masaaki</creatorcontrib><creatorcontrib>Matsui, Hideki</creatorcontrib><creatorcontrib>Janjua, Najma A.</creatorcontrib><creatorcontrib>Suwaki, Hiroshi</creatorcontrib><creatorcontrib>Okada, Yasushi</creatorcontrib><creatorcontrib>Murakami, Tetuhide H.</creatorcontrib><creatorcontrib>Negi, Tetsuro</creatorcontrib><creatorcontrib>Nakahara, Sukita</creatorcontrib><creatorcontrib>Hatase, Osamu</creatorcontrib><title>Effect of embryonic hippocampal transplantation in amygdaloid kindled rat</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Embryonic neural tissue was transplanted into previously kindled rats. A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.</description><subject>Amygdala - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Tissue Transplantation - physiology</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - physiology</subject><subject>Cerebral Cortex - transplantation</subject><subject>Epilepsy</subject><subject>Female</subject><subject>Fetal Tissue Transplantation - physiology</subject><subject>Hippocampus</subject><subject>Hippocampus - anatomy & histology</subject><subject>Hippocampus - embryology</subject><subject>Hippocampus - transplantation</subject><subject>Kindling</subject><subject>Kindling, Neurologic - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Transplantation</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVtL5DAUgIO46OjuP1Dog4g-dDdpLk1fBJFxVhB82X0Op7lotG1q0hHm35sywzwqBELO-c6FLwidEfybYCL-YIxFKZuGXjX0uiGUVOXqAC2IrKtSVAwfosUeOUYnKb3mJ6UNPkJHknHKarJAD0vnrJ6K4Arbt3ETBq-LFz-OQUM_QldMEYY0djBMMPkwFH4ooN88G-iCN8WbH0xnTRFh-ol-OOiS_bW7T9H_--W_u7_l49Pq4e72sdRM0qnUQlreUt1yA0YYITGnmvBKEuCCCY0FJSxvj4XhxgGFxhneEmZYDdTlwCm63PYdY3hf2zSp3idtu7yiDeukai6oxDX9FiR5HKOyyiDbgjqGlKJ1aoy-h7hRBKtZtZo9qtmjms-sWq1y2fmu_7rtrdkX7dzm_MUuD0lD57JI7dMeY5zXeXzGbraYzdI-vI0qaW8HbY2P-WeUCf7rPT4B56WaPA</recordid><startdate>19930212</startdate><enddate>19930212</enddate><creator>Miyamoto, Osamu</creator><creator>Itano, Toshifumi</creator><creator>Yamamoto, Yoshitaka</creator><creator>Tokuda, Masaaki</creator><creator>Matsui, Hideki</creator><creator>Janjua, Najma A.</creator><creator>Suwaki, Hiroshi</creator><creator>Okada, Yasushi</creator><creator>Murakami, Tetuhide H.</creator><creator>Negi, Tetsuro</creator><creator>Nakahara, Sukita</creator><creator>Hatase, Osamu</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19930212</creationdate><title>Effect of embryonic hippocampal transplantation in amygdaloid kindled rat</title><author>Miyamoto, Osamu ; Itano, Toshifumi ; Yamamoto, Yoshitaka ; Tokuda, Masaaki ; Matsui, Hideki ; Janjua, Najma A. ; Suwaki, Hiroshi ; Okada, Yasushi ; Murakami, Tetuhide H. ; Negi, Tetsuro ; Nakahara, Sukita ; Hatase, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-c68e5b3cb5dad6d68053c15281a5646c0631424006d5dfa3a9fd5b14d47a3ffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amygdala - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Tissue Transplantation - physiology</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - physiology</topic><topic>Cerebral Cortex - transplantation</topic><topic>Epilepsy</topic><topic>Female</topic><topic>Fetal Tissue Transplantation - physiology</topic><topic>Hippocampus</topic><topic>Hippocampus - anatomy & histology</topic><topic>Hippocampus - embryology</topic><topic>Hippocampus - transplantation</topic><topic>Kindling</topic><topic>Kindling, Neurologic - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. 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A thirteen- to fourteen-day embryonic hippocampal cell suspension was grafted in the stratum oriens near the CA2 area of the hippocampus. Almost 80% of the animals had a good recovery and became seizure-free. Injection of neocortical cells or saline did not show any positive effect on the kindling susceptibility. Although 20 day embryonic cell transplantation was also effective, the effect did not last as long as the 13- to 14-day embryonic transplantation. These observations open the possibility that the neural grafts may be used for therapy of medically intractable epilepsies.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>8453471</pmid><doi>10.1016/0006-8993(93)91312-G</doi><tpages>5</tpages></addata></record> |
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| ispartof | Brain research, 1993-02, Vol.603 (1), p.143-147 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amygdala - physiology Animals Biological and medical sciences Brain Tissue Transplantation - physiology Cerebral Cortex - cytology Cerebral Cortex - physiology Cerebral Cortex - transplantation Epilepsy Female Fetal Tissue Transplantation - physiology Hippocampus Hippocampus - anatomy & histology Hippocampus - embryology Hippocampus - transplantation Kindling Kindling, Neurologic - physiology Male Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Pregnancy Rats Rats, Sprague-Dawley Transplantation |
| title | Effect of embryonic hippocampal transplantation in amygdaloid kindled rat |
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