Effects of tissue plasminogen activator therapy on the frequency of acute right ventricular myocardial infarction associated with acute left ventricular infarction
To assess the effects of reperfusion therapy on acute right ventricular myocardial infarction, we studied at necropsy the hearts from 51 patients who died after receiving intravenous recombinant tissue plasminogen activator for acute left ventricular myocardial infarction as part of the Thrombolysis...
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| Veröffentlicht in: | International journal of cardiology 1993-02, Vol.38 (2), p.151-158 |
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| creator | Kalan, Jay M. David Gertz, S. Kragel, Amy H. Berger, Peter B. Roberts, William C. Ryan, Thomas J. |
| description | To assess the effects of reperfusion therapy on acute right ventricular myocardial infarction, we studied at necropsy the hearts from 51 patients who died after receiving intravenous recombinant tissue plasminogen activator for acute left ventricular myocardial infarction as part of the Thrombolysis in Myocardial Infarction (TIMI) study. Right ventricular infarction occurred in none of 29 patients with infarction of the anterior wall of the left ventricle and in 8 of 22 patients (36%) with infarction of the posterior (inferior) wall of the left ventricle. Of the 22 patients with posterior wall infarction, the 8 patients with right ventricular infarction were compared to the 14 patients without right ventricular infarction. The patients with right ventricular infarction had a longer mean interval from tissue plasminogen activator infusion to peak creatine phosphokinase level (19 vs. 11 h,
P < 0.03), a lower frequency of hemorrhagic necrosis (2 of 8 vs. 10 of 14,
P < 0.04) and higher frequency of luminal thrombus in the infarct-related coronary artery (6 of 8 vs. 3 of 14,
P = 0.054). Each of these findings is associated with the absence of coronary reperfusion. Thus, successful reperfusion following acute left ventricular myocardial infarction appears to be associated with a decreased frequency of concomitant right ventricular myocardial infarction. |
| doi_str_mv | 10.1016/0167-5273(93)90174-F |
| format | Article |
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P < 0.03), a lower frequency of hemorrhagic necrosis (2 of 8 vs. 10 of 14,
P < 0.04) and higher frequency of luminal thrombus in the infarct-related coronary artery (6 of 8 vs. 3 of 14,
P = 0.054). Each of these findings is associated with the absence of coronary reperfusion. Thus, successful reperfusion following acute left ventricular myocardial infarction appears to be associated with a decreased frequency of concomitant right ventricular myocardial infarction.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/0167-5273(93)90174-F</identifier><identifier>PMID: 8454377</identifier><language>eng</language><publisher>Netherlands: Elsevier Ireland Ltd</publisher><subject>Coronary artery disease ; Creatine Kinase - blood ; Female ; Heart Ventricles ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - drug therapy ; Myocardial Infarction - pathology ; Myocardium - pathology ; Necrosis ; Reperfusion ; Right ventricular infarction ; Thrombolysis ; Thrombolytic Therapy ; Tissue Plasminogen Activator - administration & dosage ; Tissue Plasminogen Activator - therapeutic use</subject><ispartof>International journal of cardiology, 1993-02, Vol.38 (2), p.151-158</ispartof><rights>1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-eb477c4046555c87eba45d4c4e72b2f451ab3e10387e6a370ab61dfe30666b443</citedby><cites>FETCH-LOGICAL-c357t-eb477c4046555c87eba45d4c4e72b2f451ab3e10387e6a370ab61dfe30666b443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0167-5273(93)90174-F$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8454377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalan, Jay M.</creatorcontrib><creatorcontrib>David Gertz, S.</creatorcontrib><creatorcontrib>Kragel, Amy H.</creatorcontrib><creatorcontrib>Berger, Peter B.</creatorcontrib><creatorcontrib>Roberts, William C.</creatorcontrib><creatorcontrib>Ryan, Thomas J.</creatorcontrib><title>Effects of tissue plasminogen activator therapy on the frequency of acute right ventricular myocardial infarction associated with acute left ventricular infarction</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>To assess the effects of reperfusion therapy on acute right ventricular myocardial infarction, we studied at necropsy the hearts from 51 patients who died after receiving intravenous recombinant tissue plasminogen activator for acute left ventricular myocardial infarction as part of the Thrombolysis in Myocardial Infarction (TIMI) study. Right ventricular infarction occurred in none of 29 patients with infarction of the anterior wall of the left ventricle and in 8 of 22 patients (36%) with infarction of the posterior (inferior) wall of the left ventricle. Of the 22 patients with posterior wall infarction, the 8 patients with right ventricular infarction were compared to the 14 patients without right ventricular infarction. The patients with right ventricular infarction had a longer mean interval from tissue plasminogen activator infusion to peak creatine phosphokinase level (19 vs. 11 h,
P < 0.03), a lower frequency of hemorrhagic necrosis (2 of 8 vs. 10 of 14,
P < 0.04) and higher frequency of luminal thrombus in the infarct-related coronary artery (6 of 8 vs. 3 of 14,
P = 0.054). Each of these findings is associated with the absence of coronary reperfusion. Thus, successful reperfusion following acute left ventricular myocardial infarction appears to be associated with a decreased frequency of concomitant right ventricular myocardial infarction.</description><subject>Coronary artery disease</subject><subject>Creatine Kinase - blood</subject><subject>Female</subject><subject>Heart Ventricles</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardium - pathology</subject><subject>Necrosis</subject><subject>Reperfusion</subject><subject>Right ventricular infarction</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy</subject><subject>Tissue Plasminogen Activator - administration & dosage</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-KFDEQxoMo67j6Bgo5yXpoTSb_pi-CLDsqLOxlPYfqdGUn0t0Zk_TIPI8vumlmWPEiJKSgvt8Xqj5C3nL2kTOuP9VrGrU24qoVH1rGjWy2z8iKb2rBjZLPyepJ8pK8yvknY0y27eaCXGykksKYFflz4z26kmn0tIScZ6T7AfIYpviAEwVXwgFKTLTsMMH-SOO0lNQn_DXj5I4LCG4uSFN42BV6wKmk4OYBEh2P0UHqAww0TB5SNas45BxdgII9_R3K7kwP6P-F_xKvyQsPQ8Y35_eS_Nje3F9_a27vvn6__nLbOKFMabCTxjjJpFZKuY3BDqTqpZNo1t3aS8WhE8iZqC0NwjDoNO89Cqa17qQUl-T9yXefYh0uFzuG7HAYYMI4Z2uUrpTmVShPQpdizgm93acwQjpazuySjV0Wb5fF27aeJRu7rdi7s__cjdg_Qecwav_zqY91yEPAZLMLdcfYh1Qzsn0M___gEVfYoxM</recordid><startdate>19930201</startdate><enddate>19930201</enddate><creator>Kalan, Jay M.</creator><creator>David Gertz, S.</creator><creator>Kragel, Amy H.</creator><creator>Berger, Peter B.</creator><creator>Roberts, William C.</creator><creator>Ryan, Thomas J.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930201</creationdate><title>Effects of tissue plasminogen activator therapy on the frequency of acute right ventricular myocardial infarction associated with acute left ventricular infarction</title><author>Kalan, Jay M. ; David Gertz, S. ; Kragel, Amy H. ; Berger, Peter B. ; Roberts, William C. ; Ryan, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-eb477c4046555c87eba45d4c4e72b2f451ab3e10387e6a370ab61dfe30666b443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Coronary artery disease</topic><topic>Creatine Kinase - blood</topic><topic>Female</topic><topic>Heart Ventricles</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - drug therapy</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardium - pathology</topic><topic>Necrosis</topic><topic>Reperfusion</topic><topic>Right ventricular infarction</topic><topic>Thrombolysis</topic><topic>Thrombolytic Therapy</topic><topic>Tissue Plasminogen Activator - administration & dosage</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalan, Jay M.</creatorcontrib><creatorcontrib>David Gertz, S.</creatorcontrib><creatorcontrib>Kragel, Amy H.</creatorcontrib><creatorcontrib>Berger, Peter B.</creatorcontrib><creatorcontrib>Roberts, William C.</creatorcontrib><creatorcontrib>Ryan, Thomas J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalan, Jay M.</au><au>David Gertz, S.</au><au>Kragel, Amy H.</au><au>Berger, Peter B.</au><au>Roberts, William C.</au><au>Ryan, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of tissue plasminogen activator therapy on the frequency of acute right ventricular myocardial infarction associated with acute left ventricular infarction</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>1993-02-01</date><risdate>1993</risdate><volume>38</volume><issue>2</issue><spage>151</spage><epage>158</epage><pages>151-158</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>To assess the effects of reperfusion therapy on acute right ventricular myocardial infarction, we studied at necropsy the hearts from 51 patients who died after receiving intravenous recombinant tissue plasminogen activator for acute left ventricular myocardial infarction as part of the Thrombolysis in Myocardial Infarction (TIMI) study. Right ventricular infarction occurred in none of 29 patients with infarction of the anterior wall of the left ventricle and in 8 of 22 patients (36%) with infarction of the posterior (inferior) wall of the left ventricle. Of the 22 patients with posterior wall infarction, the 8 patients with right ventricular infarction were compared to the 14 patients without right ventricular infarction. The patients with right ventricular infarction had a longer mean interval from tissue plasminogen activator infusion to peak creatine phosphokinase level (19 vs. 11 h,
P < 0.03), a lower frequency of hemorrhagic necrosis (2 of 8 vs. 10 of 14,
P < 0.04) and higher frequency of luminal thrombus in the infarct-related coronary artery (6 of 8 vs. 3 of 14,
P = 0.054). Each of these findings is associated with the absence of coronary reperfusion. Thus, successful reperfusion following acute left ventricular myocardial infarction appears to be associated with a decreased frequency of concomitant right ventricular myocardial infarction.</abstract><cop>Netherlands</cop><pub>Elsevier Ireland Ltd</pub><pmid>8454377</pmid><doi>10.1016/0167-5273(93)90174-F</doi><tpages>8</tpages></addata></record> |
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| ispartof | International journal of cardiology, 1993-02, Vol.38 (2), p.151-158 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Coronary artery disease Creatine Kinase - blood Female Heart Ventricles Humans Infusions, Intravenous Male Middle Aged Myocardial Infarction - blood Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardium - pathology Necrosis Reperfusion Right ventricular infarction Thrombolysis Thrombolytic Therapy Tissue Plasminogen Activator - administration & dosage Tissue Plasminogen Activator - therapeutic use |
| title | Effects of tissue plasminogen activator therapy on the frequency of acute right ventricular myocardial infarction associated with acute left ventricular infarction |
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