TH1 and TH2 cell antigen receptors in experimental leishmaniasis
The complexity and chronicity of parasitic infections have obscured the identification of biologically relevant antigens. Analysis of the T cell receptor repertoire used by mice infected with Leishmania major revealed the expansion of a restricted population of CD4+ cells. These cells expressed the...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1993-03, Vol.259 (5100), p.1457-1460 |
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| container_issue | 5100 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | REINER, S. L ZHI-EN WANG FARAH HATAM SCOTT, P LOCKSLEY, R. M |
| description | The complexity and chronicity of parasitic infections have obscured the identification of biologically relevant antigens. Analysis of the T cell receptor repertoire used by mice infected with Leishmania major revealed the expansion of a restricted population of CD4+ cells. These cells expressed the V alpha 8-J alpha TA72, V beta 4 heterodimer in both progressive infection and protective immunity and across several major histocompatibility haplotypes. Thus, the same immunodominant parasite epitope drives the disparate outcomes of this infectious process, suggesting that candidate vaccine antigens selected by screening of immune individuals may be capable of exacerbating disease in genetically susceptible individuals. |
| doi_str_mv | 10.1126/science.8451641 |
| format | Article |
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Thus, the same immunodominant parasite epitope drives the disparate outcomes of this infectious process, suggesting that candidate vaccine antigens selected by screening of immune individuals may be capable of exacerbating disease in genetically susceptible individuals.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.8451641</identifier><identifier>PMID: 8451641</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Base Sequence ; Biological and medical sciences ; CD4 Antigens - analysis ; Cloning, Molecular ; Human protozoal diseases ; Infectious diseases ; Leishmania tropica ; Leishmaniasis, Cutaneous - immunology ; Leshmaniasis ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Oligodeoxyribonucleotides ; Parasitic diseases ; Polymerase Chain Reaction - methods ; Protozoal diseases ; Receptors, Antigen, T-Cell - analysis ; Receptors, Antigen, T-Cell - genetics ; Receptors, Antigen, T-Cell - metabolism ; Receptors, Antigen, T-Cell, alpha-beta - analysis ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, alpha-beta - metabolism ; Reference Values ; RNA, Messenger - genetics ; RNA, Messenger - isolation & purification ; T-Lymphocyte Subsets - immunology ; Tropical medicine</subject><ispartof>Science (American Association for the Advancement of Science), 1993-03, Vol.259 (5100), p.1457-1460</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4643150$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8451641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>REINER, S. 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Thus, the same immunodominant parasite epitope drives the disparate outcomes of this infectious process, suggesting that candidate vaccine antigens selected by screening of immune individuals may be capable of exacerbating disease in genetically susceptible individuals.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens - analysis</subject><subject>Cloning, Molecular</subject><subject>Human protozoal diseases</subject><subject>Infectious diseases</subject><subject>Leishmania tropica</subject><subject>Leishmaniasis, Cutaneous - immunology</subject><subject>Leshmaniasis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Molecular Sequence Data</subject><subject>Oligodeoxyribonucleotides</subject><subject>Parasitic diseases</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Protozoal diseases</subject><subject>Receptors, Antigen, T-Cell - analysis</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Receptors, Antigen, T-Cell - metabolism</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - analysis</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - metabolism</subject><subject>Reference Values</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - isolation & purification</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Tropical medicine</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j0tLw0AUhQdRaq2uXQmzEHepdx6Zx04paoWCm7oOk8mNHUmmMZOC_vtGDK4ul-_jcA4h1wyWjHF1n3zA6HFpZM6UZCdkzsDmmeUgTskcQKjMgM7PyUVKnwAjs2JGZpM-Jw_bNaMuVnS75tRj04zPED4w0h49dsO-TzREit8d9qHFOLiGNhjSrnUxuBTSJTmrXZPwaroL8v78tF2ts83by-vqcZPtuNRDJkGUXqtcmbp0lQcvuTTMG86sBidKUzEBzJRcei_LSiP31nKLtRZmZFosyN1fbtfvvw6YhqIN6bewi7g_pELnSigxzl6Qm0k8lC1WRTf2dv1PMU0e-e3EXfKuqXsXfUj_mlRSsBzEEdboZIw</recordid><startdate>19930305</startdate><enddate>19930305</enddate><creator>REINER, S. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h247t-403bc76568fbadc0c42481c821970a3b8d13018b24cc4bd7e2c9929ef7388d173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>CD4 Antigens - analysis</topic><topic>Cloning, Molecular</topic><topic>Human protozoal diseases</topic><topic>Infectious diseases</topic><topic>Leishmania tropica</topic><topic>Leishmaniasis, Cutaneous - immunology</topic><topic>Leshmaniasis</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Molecular Sequence Data</topic><topic>Oligodeoxyribonucleotides</topic><topic>Parasitic diseases</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Protozoal diseases</topic><topic>Receptors, Antigen, T-Cell - analysis</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Receptors, Antigen, T-Cell - metabolism</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - analysis</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - metabolism</topic><topic>Reference Values</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - isolation & purification</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REINER, S. L</creatorcontrib><creatorcontrib>ZHI-EN WANG</creatorcontrib><creatorcontrib>FARAH HATAM</creatorcontrib><creatorcontrib>SCOTT, P</creatorcontrib><creatorcontrib>LOCKSLEY, R. M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REINER, S. L</au><au>ZHI-EN WANG</au><au>FARAH HATAM</au><au>SCOTT, P</au><au>LOCKSLEY, R. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>TH1 and TH2 cell antigen receptors in experimental leishmaniasis</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1993-03-05</date><risdate>1993</risdate><volume>259</volume><issue>5100</issue><spage>1457</spage><epage>1460</epage><pages>1457-1460</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>The complexity and chronicity of parasitic infections have obscured the identification of biologically relevant antigens. Analysis of the T cell receptor repertoire used by mice infected with Leishmania major revealed the expansion of a restricted population of CD4+ cells. These cells expressed the V alpha 8-J alpha TA72, V beta 4 heterodimer in both progressive infection and protective immunity and across several major histocompatibility haplotypes. Thus, the same immunodominant parasite epitope drives the disparate outcomes of this infectious process, suggesting that candidate vaccine antigens selected by screening of immune individuals may be capable of exacerbating disease in genetically susceptible individuals.</abstract><cop>Washington, DC</cop><pub>American Association for the Advancement of Science</pub><pmid>8451641</pmid><doi>10.1126/science.8451641</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1993-03, Vol.259 (5100), p.1457-1460 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75636320 |
| source | MEDLINE; Science Online_科学在线; JSTOR |
| subjects | Animals Base Sequence Biological and medical sciences CD4 Antigens - analysis Cloning, Molecular Human protozoal diseases Infectious diseases Leishmania tropica Leishmaniasis, Cutaneous - immunology Leshmaniasis Medical sciences Mice Mice, Inbred BALB C Molecular Sequence Data Oligodeoxyribonucleotides Parasitic diseases Polymerase Chain Reaction - methods Protozoal diseases Receptors, Antigen, T-Cell - analysis Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism Receptors, Antigen, T-Cell, alpha-beta - analysis Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism Reference Values RNA, Messenger - genetics RNA, Messenger - isolation & purification T-Lymphocyte Subsets - immunology Tropical medicine |
| title | TH1 and TH2 cell antigen receptors in experimental leishmaniasis |
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