A comprehensive algorithm for determining whether a run-in strategy will be a cost-effective design modification in a randomized clinical trial

In randomized clinical trials, poor compliance and treatment intolerance lead to reduced between‐group differences, increased sample size requirements, and increased cost. A run‐in strategy is intended to reduce these problems. In this paper, we develop a comprehensive set of measures specifically s...

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Veröffentlicht in:	Statistics in medicine 1993-01, Vol.12 (2), p.111-128
Hauptverfasser:	Schechtman, Kenneth B., Gordon, Mae E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Clinical Trials as Topic - economics Cost-Benefit Analysis Humans Patient Compliance Randomized Controlled Trials as Topic - economics Research Design
Online-Zugang:	Volltext
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