Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist

NON-PEPTIDE ligands for peptide receptors have been discovered in several systems through file screening programs 1–6 , but the mechanism of action for these candidate drugs is obscure as they do not chemically resemble the native peptides. The compound CP 96345 is a high-affinity, non-peptide antag...

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Veröffentlicht in:	Nature (London) 1993-03, Vol.362 (6418), p.345-348
Hauptverfasser:	Gether, Ulrik, Johansen, Teit E., Snider, R. Michael, Lowe, John A., Nakanishi, Shigetada, Schwartz, Thue W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Biological and medical sciences Biphenyl Compounds - chemistry Cell receptors Cell structures and functions Epitopes Fundamental and applied biological sciences. Psychology Genetic engineering Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humanities and Social Sciences letter Molecular and cellular biology Molecular Sequence Data multidisciplinary Proteins Receptors, Neurokinin-2 Receptors, Neurotransmitter - chemistry Recombinant Proteins - chemistry Science Tachykinins - chemistry
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