EFFECTS OF rHuEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS PATIENTS WITH CORONARY ARTERY DISEASE
We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9±0.7g/dl, (me...
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| Veröffentlicht in: | JAPANESE CIRCULATION JOURNAL 1993/05/20, Vol.57(2), pp.131-137 |
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| container_title | JAPANESE CIRCULATION JOURNAL |
| container_volume | 57 |
| creator | HASE, HIROKI IMAMURA, YOSHIHIKO NAKAMURA, RYOICHI INISHI, YOJI MACHII, KIYOSHI MAGUCHI, TETSUYA |
| description | We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9±0.7g/dl, (mean±S.D.) rose to 10.4±1.1 g/dl, (p |
| doi_str_mv | 10.1253/jcj.57.131 |
| format | Article |
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The initial hemoglobin concentration of 7.9±0.7g/dl, (mean±S.D.) rose to 10.4±1.1 g/dl, (p<0.01) after three months of rHuEPO therapy. The partial correction of renal anemia resulted in a significant increase in exercise duration (from 278±84 sec to 384±74 sec, p<0.01) and maximum pressure-rate product (from 228.3±50.3mmHg·bpm/l02 to 262.8±40.4 mmHg·bpm/102, p<0.01). The maximum exercise-induced ST segment depression significantly decreased after treatment (from 1.3 ±0.5 mm to 0.5±0.5 mm, p<0.05). These results suggest that the improvement in maximum coronary oxygen supply exceeded the increased maximum myocardial oxygen requirements after the partial correction of renal anemia by rHuEPO therapy in hemodialysis patients with coronary artery disease.</description><identifier>ISSN: 0047-1828</identifier><identifier>EISSN: 1347-4839</identifier><identifier>DOI: 10.1253/jcj.57.131</identifier><identifier>PMID: 8450597</identifier><identifier>CODEN: JCIRA2</identifier><language>eng</language><publisher>Kyoto: The Japanese Circulation Society</publisher><subject>Adult ; Anemia - etiology ; Anemia - prevention & control ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Coronary artery disease ; Coronary Disease - complications ; Erythropoietin - therapeutic use ; Exercise Test ; Exercise-induced ST depression ; Female ; Hemodialysis ; Humans ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Physical Endurance - drug effects ; Recombinant human erythropoietin ; Recombinant Proteins - therapeutic use ; Renal Dialysis - methods ; Treadmill exercise testing</subject><ispartof>JAPANESE CIRCULATION JOURNAL, 1993/05/20, Vol.57(2), pp.131-137</ispartof><rights>Japanese Circulation Society</rights><rights>1993 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-b281174f038c47707c2a6c2f0df9180a97e5be478eb01d110b9ced8741a4e8603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4743387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8450597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HASE, HIROKI</creatorcontrib><creatorcontrib>IMAMURA, YOSHIHIKO</creatorcontrib><creatorcontrib>NAKAMURA, RYOICHI</creatorcontrib><creatorcontrib>INISHI, YOJI</creatorcontrib><creatorcontrib>MACHII, KIYOSHI</creatorcontrib><creatorcontrib>MAGUCHI, TETSUYA</creatorcontrib><title>EFFECTS OF rHuEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS PATIENTS WITH CORONARY ARTERY DISEASE</title><title>JAPANESE CIRCULATION JOURNAL</title><addtitle>JAPANESE CIRCULATION JOURNAL</addtitle><description>We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9±0.7g/dl, (mean±S.D.) rose to 10.4±1.1 g/dl, (p<0.01) after three months of rHuEPO therapy. The partial correction of renal anemia resulted in a significant increase in exercise duration (from 278±84 sec to 384±74 sec, p<0.01) and maximum pressure-rate product (from 228.3±50.3mmHg·bpm/l02 to 262.8±40.4 mmHg·bpm/102, p<0.01). The maximum exercise-induced ST segment depression significantly decreased after treatment (from 1.3 ±0.5 mm to 0.5±0.5 mm, p<0.05). These results suggest that the improvement in maximum coronary oxygen supply exceeded the increased maximum myocardial oxygen requirements after the partial correction of renal anemia by rHuEPO therapy in hemodialysis patients with coronary artery disease.</description><subject>Adult</subject><subject>Anemia - etiology</subject><subject>Anemia - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - complications</subject><subject>Erythropoietin - therapeutic use</subject><subject>Exercise Test</subject><subject>Exercise-induced ST depression</subject><subject>Female</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Endurance - drug effects</subject><subject>Recombinant human erythropoietin</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>Renal Dialysis - methods</subject><subject>Treadmill exercise testing</subject><issn>0047-1828</issn><issn>1347-4839</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEGL2zAQhUXpss1ue-m9oEPpYSGpZEmWfDRepTZk42C7tDkJWZZbGyfZSsmh_74KCellZuB97w08AD5itMARI19HMy4YX2CC34AZJpTPqSDJWzBDKNxYROIdePB-RCjilLF7cC8oQyzhM9DJ5VJmTQ3LJXT5SW5K2OSySjdbWK6h_CmrrKglzNJNmhXNFhZrmMuX8rlIV9u6qOEmbQq5Dv4fRZPDrKzKdVptYVo1Mqzn4E1r-R7c9Xry9sN1P4LvS9lk-XxVfiuydDU3DNHjvI0Expz2iAhDOUfcRDo2UY-6PsEC6YRb1lrKhW0R7jBGbWJsJzjFmloRI_IIvlxyX93hz8n6o9oN3thp0nt7OHnFWUwIiXEAny6gcQfvne3Vqxt22v1VGKlzpSpUqhhXodIAf7qmntqd7W7otcOgf77q2hs99U7vzeBvGOWUEHHG5AUb_VH_sjddu-NgJqvM4MyIkxid_0aXEd7_139rp-ye_AMyg424</recordid><startdate>19930201</startdate><enddate>19930201</enddate><creator>HASE, HIROKI</creator><creator>IMAMURA, YOSHIHIKO</creator><creator>NAKAMURA, RYOICHI</creator><creator>INISHI, YOJI</creator><creator>MACHII, KIYOSHI</creator><creator>MAGUCHI, TETSUYA</creator><general>The Japanese Circulation Society</general><general>Japanese Circulation Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19930201</creationdate><title>EFFECTS OF rHuEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS PATIENTS WITH CORONARY ARTERY DISEASE</title><author>HASE, HIROKI ; IMAMURA, YOSHIHIKO ; NAKAMURA, RYOICHI ; INISHI, YOJI ; MACHII, KIYOSHI ; MAGUCHI, TETSUYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-b281174f038c47707c2a6c2f0df9180a97e5be478eb01d110b9ced8741a4e8603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Anemia - etiology</topic><topic>Anemia - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - complications</topic><topic>Erythropoietin - therapeutic use</topic><topic>Exercise Test</topic><topic>Exercise-induced ST depression</topic><topic>Female</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Endurance - drug effects</topic><topic>Recombinant human erythropoietin</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>Renal Dialysis - methods</topic><topic>Treadmill exercise testing</topic><toplevel>online_resources</toplevel><creatorcontrib>HASE, HIROKI</creatorcontrib><creatorcontrib>IMAMURA, YOSHIHIKO</creatorcontrib><creatorcontrib>NAKAMURA, RYOICHI</creatorcontrib><creatorcontrib>INISHI, YOJI</creatorcontrib><creatorcontrib>MACHII, KIYOSHI</creatorcontrib><creatorcontrib>MAGUCHI, TETSUYA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>JAPANESE CIRCULATION JOURNAL</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HASE, HIROKI</au><au>IMAMURA, YOSHIHIKO</au><au>NAKAMURA, RYOICHI</au><au>INISHI, YOJI</au><au>MACHII, KIYOSHI</au><au>MAGUCHI, TETSUYA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF rHuEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS PATIENTS WITH CORONARY ARTERY DISEASE</atitle><jtitle>JAPANESE CIRCULATION JOURNAL</jtitle><addtitle>JAPANESE CIRCULATION JOURNAL</addtitle><date>1993-02-01</date><risdate>1993</risdate><volume>57</volume><issue>2</issue><spage>131</spage><epage>137</epage><pages>131-137</pages><issn>0047-1828</issn><eissn>1347-4839</eissn><coden>JCIRA2</coden><abstract>We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9±0.7g/dl, (mean±S.D.) rose to 10.4±1.1 g/dl, (p<0.01) after three months of rHuEPO therapy. The partial correction of renal anemia resulted in a significant increase in exercise duration (from 278±84 sec to 384±74 sec, p<0.01) and maximum pressure-rate product (from 228.3±50.3mmHg·bpm/l02 to 262.8±40.4 mmHg·bpm/102, p<0.01). The maximum exercise-induced ST segment depression significantly decreased after treatment (from 1.3 ±0.5 mm to 0.5±0.5 mm, p<0.05). These results suggest that the improvement in maximum coronary oxygen supply exceeded the increased maximum myocardial oxygen requirements after the partial correction of renal anemia by rHuEPO therapy in hemodialysis patients with coronary artery disease.</abstract><cop>Kyoto</cop><pub>The Japanese Circulation Society</pub><pmid>8450597</pmid><doi>10.1253/jcj.57.131</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Anemia - etiology Anemia - prevention & control Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Coronary artery disease Coronary Disease - complications Erythropoietin - therapeutic use Exercise Test Exercise-induced ST depression Female Hemodialysis Humans Male Medical sciences Middle Aged Pharmacology. Drug treatments Physical Endurance - drug effects Recombinant human erythropoietin Recombinant Proteins - therapeutic use Renal Dialysis - methods Treadmill exercise testing |
| title | EFFECTS OF rHuEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS PATIENTS WITH CORONARY ARTERY DISEASE |
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