Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy
The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1993-04, Vol.53 (7), p.1489-1492 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | CHI-HO MOK, S BELL, D. A KNAPP, R. C FISHBAUGH, P. M WELCH, W. R MUTO, M. G BERKOWITZ, R. S SAI-WAH TSAO |
| description | The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases. |
| format | Article |
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A ; KNAPP, R. C ; FISHBAUGH, P. M ; WELCH, W. R ; MUTO, M. G ; BERKOWITZ, R. S ; SAI-WAH TSAO</creator><creatorcontrib>CHI-HO MOK, S ; BELL, D. A ; KNAPP, R. C ; FISHBAUGH, P. M ; WELCH, W. R ; MUTO, M. G ; BERKOWITZ, R. S ; SAI-WAH TSAO</creatorcontrib><description>The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 8384077</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenocarcinoma, Mucinous - genetics ; Adenocarcinoma, Mucinous - pathology ; Base Sequence ; Biological and medical sciences ; Codon - genetics ; Cystadenocarcinoma - genetics ; Cystadenocarcinoma - pathology ; DNA Mutational Analysis ; Female ; Female genital diseases ; Genes, ras - genetics ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Molecular Sequence Data ; Mutation - genetics ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - pathology ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 1993-04, Vol.53 (7), p.1489-1492</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4679385$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8384077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHI-HO MOK, S</creatorcontrib><creatorcontrib>BELL, D. A</creatorcontrib><creatorcontrib>KNAPP, R. C</creatorcontrib><creatorcontrib>FISHBAUGH, P. M</creatorcontrib><creatorcontrib>WELCH, W. R</creatorcontrib><creatorcontrib>MUTO, M. G</creatorcontrib><creatorcontrib>BERKOWITZ, R. S</creatorcontrib><creatorcontrib>SAI-WAH TSAO</creatorcontrib><title>Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases.</description><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Codon - genetics</subject><subject>Cystadenocarcinoma - genetics</subject><subject>Cystadenocarcinoma - pathology</subject><subject>DNA Mutational Analysis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Genes, ras - genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Mutation - genetics</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LxDAQxYMo67r6EYQexFuh-ddkj7KoK6542ZuHkqbTbSRN1iQV9tsbsXh6DO_3hnlzhpaYU1kKxvg5WlZVJUvOBLlEVzF-5pHjii_QQlLJKiGW6ONtSioZ7wrfF69lULE4Bp-8d9ofwEFhXDFMo8r-twomKxxNGsAaZYs0jT7E32TrQwfBmhwYlTUHp5w-XaOLXtkIN7Ou0P7pcb_Zlrv355fNw64cSC1TSUTHCKkxWYuW6privqUtk1oClZJzCTVg0gLV_ZqTXjDKoKu0xpwQyYSgK3T_tzYf_jVBTM1oogZrlQM_xUbwmhLMcAZvZ3BqR-iaYzCjCqdmfkb272ZfRa1sH3IJE_8xVos1lZz-AL6zaQk</recordid><startdate>19930401</startdate><enddate>19930401</enddate><creator>CHI-HO MOK, S</creator><creator>BELL, D. A</creator><creator>KNAPP, R. 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S ; SAI-WAH TSAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-27d42261297b3c631fb3b48c8e388558e6e12be3cf952f7434ed0cc152284773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adenocarcinoma, Mucinous - genetics</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Codon - genetics</topic><topic>Cystadenocarcinoma - genetics</topic><topic>Cystadenocarcinoma - pathology</topic><topic>DNA Mutational Analysis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Genes, ras - genetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Mutation - genetics</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHI-HO MOK, S</creatorcontrib><creatorcontrib>BELL, D. A</creatorcontrib><creatorcontrib>KNAPP, R. C</creatorcontrib><creatorcontrib>FISHBAUGH, P. M</creatorcontrib><creatorcontrib>WELCH, W. R</creatorcontrib><creatorcontrib>MUTO, M. G</creatorcontrib><creatorcontrib>BERKOWITZ, R. 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S</au><au>SAI-WAH TSAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1993-04-01</date><risdate>1993</risdate><volume>53</volume><issue>7</issue><spage>1489</spage><epage>1492</epage><pages>1489-1492</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>The mutation of K-ras protooncogene was examined in 44 cases of borderline ovarian epithelial tumors and 18 cases of invasive ovarian carcinomas. In borderline tumors, K-ras mutations are a common feature, having been found in 21 of 44 cases (48%). Twenty of the 21 mutations were identified at codon 12, and one was identified at codon 13. A detailed analysis of the mutation pattern of K-ras revealed a close association with the histological cell types of the tumor. Mutation of K-ras was detected at a higher frequency in mucinous borderline tumor (identified in 12 of 19 cases) compared to serous borderline tumor (identified in 9 of 25 cases). K-ras mutation was also detected in invasive mucinous and serous ovarian carcinomas, hence supporting the notion that borderline ovarian tumors may represent a pathological continuum between benign and frankly invasive diseases.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>8384077</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1993-04, Vol.53 (7), p.1489-1492 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - pathology Base Sequence Biological and medical sciences Codon - genetics Cystadenocarcinoma - genetics Cystadenocarcinoma - pathology DNA Mutational Analysis Female Female genital diseases Genes, ras - genetics Gynecology. Andrology. Obstetrics Humans Medical sciences Molecular Sequence Data Mutation - genetics Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Tumors |
| title | Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy |
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