Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)
The assembly of specific multiprotein complexes on the herpes simplex virus alpha/IE (immediate early) enhancer elements requires the interactions of the Oct-1 POU homeodomain, the viral alpha TIF (alpha-trans-induction factor) (VP16), and at least one additional cellular factor, the C1 factor. The...
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| Veröffentlicht in: | The Journal of biological chemistry 1993-03, Vol.268 (9), p.6525-6534 |
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| container_title | The Journal of biological chemistry |
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| creator | KRISTIE, T. M SHARP, P. A |
| description | The assembly of specific multiprotein complexes on the herpes simplex virus alpha/IE (immediate early) enhancer elements requires
the interactions of the Oct-1 POU homeodomain, the viral alpha TIF (alpha-trans-induction factor) (VP16), and at least one
additional cellular factor, the C1 factor. The C1 factor interacts directly with alpha TIF, likely forming an intermediate
protein complex that recognizes the Oct-1 homeodomain-DNA complex. The biochemical purification of the mammalian C1 factor
suggests that it is composed of multiple subunits of related, but heterogeneous, polypeptides. The interaction of a subset
of these polypeptides with alpha TIF is stimulated by post-translational modifications of the C1 proteins, suggesting that
this factor may be a critical target for the regulation of the herpes simplex virus alpha/IE transcription. |
| doi_str_mv | 10.1016/s0021-9258(18)53282-8 |
| format | Article |
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the interactions of the Oct-1 POU homeodomain, the viral alpha TIF (alpha-trans-induction factor) (VP16), and at least one
additional cellular factor, the C1 factor. The C1 factor interacts directly with alpha TIF, likely forming an intermediate
protein complex that recognizes the Oct-1 homeodomain-DNA complex. The biochemical purification of the mammalian C1 factor
suggests that it is composed of multiple subunits of related, but heterogeneous, polypeptides. The interaction of a subset
of these polypeptides with alpha TIF is stimulated by post-translational modifications of the C1 proteins, suggesting that
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the interactions of the Oct-1 POU homeodomain, the viral alpha TIF (alpha-trans-induction factor) (VP16), and at least one
additional cellular factor, the C1 factor. The C1 factor interacts directly with alpha TIF, likely forming an intermediate
protein complex that recognizes the Oct-1 homeodomain-DNA complex. The biochemical purification of the mammalian C1 factor
suggests that it is composed of multiple subunits of related, but heterogeneous, polypeptides. The interaction of a subset
of these polypeptides with alpha TIF is stimulated by post-translational modifications of the C1 proteins, suggesting that
this factor may be a critical target for the regulation of the herpes simplex virus alpha/IE transcription.</description><subject>Amino Acid Sequence</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HeLa Cells</subject><subject>herpes simplex virus</subject><subject>Herpes Simplex Virus Protein Vmw65 - chemistry</subject><subject>Herpes Simplex Virus Protein Vmw65 - metabolism</subject><subject>Host Cell Factor C1</subject><subject>Humans</subject><subject>Macromolecular Substances</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Multiprotein Complexes</subject><subject>Octamer Transcription Factor-1</subject><subject>Phosphorylation</subject><subject>Proteins - isolation & purification</subject><subject>Proteins - metabolism</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription. Transcription factor. Splicing. 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A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-9279d8694e03bb553c3338b2f0df788a33e07f55e26e08711300114d478a95a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Amino Acid Sequence</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HeLa Cells</topic><topic>herpes simplex virus</topic><topic>Herpes Simplex Virus Protein Vmw65 - chemistry</topic><topic>Herpes Simplex Virus Protein Vmw65 - metabolism</topic><topic>Host Cell Factor C1</topic><topic>Humans</topic><topic>Macromolecular Substances</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Multiprotein Complexes</topic><topic>Octamer Transcription Factor-1</topic><topic>Phosphorylation</topic><topic>Proteins - isolation & purification</topic><topic>Proteins - metabolism</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription. Transcription factor. Splicing. Rna processing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KRISTIE, T. M</creatorcontrib><creatorcontrib>SHARP, P. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KRISTIE, T. M</au><au>SHARP, P. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1993-03-25</date><risdate>1993</risdate><volume>268</volume><issue>9</issue><spage>6525</spage><epage>6534</epage><pages>6525-6534</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>The assembly of specific multiprotein complexes on the herpes simplex virus alpha/IE (immediate early) enhancer elements requires
the interactions of the Oct-1 POU homeodomain, the viral alpha TIF (alpha-trans-induction factor) (VP16), and at least one
additional cellular factor, the C1 factor. The C1 factor interacts directly with alpha TIF, likely forming an intermediate
protein complex that recognizes the Oct-1 homeodomain-DNA complex. The biochemical purification of the mammalian C1 factor
suggests that it is composed of multiple subunits of related, but heterogeneous, polypeptides. The interaction of a subset
of these polypeptides with alpha TIF is stimulated by post-translational modifications of the C1 proteins, suggesting that
this factor may be a critical target for the regulation of the herpes simplex virus alpha/IE transcription.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>8454622</pmid><doi>10.1016/s0021-9258(18)53282-8</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6525-6534 |
| issn | 0021-9258 1083-351X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75630801 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Biological and medical sciences Chromatography, High Pressure Liquid DNA-Binding Proteins - metabolism Fundamental and applied biological sciences. Psychology HeLa Cells herpes simplex virus Herpes Simplex Virus Protein Vmw65 - chemistry Herpes Simplex Virus Protein Vmw65 - metabolism Host Cell Factor C1 Humans Macromolecular Substances Molecular and cellular biology Molecular genetics Molecular Sequence Data Multiprotein Complexes Octamer Transcription Factor-1 Phosphorylation Proteins - isolation & purification Proteins - metabolism Transcription Factors - metabolism Transcription. Transcription factor. Splicing. Rna processing |
| title | Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16) |
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