Effect of ascorbic acid on pituitary prolactin secretion in the non-ascorbate synthesizing osteogenic disorder shionogi (ODS) rat
We examined the secretion of prolactin (PRL) in the hereditary scurvy-prone Osteogenic Disorder Shionogi (ODS) rat to investigate the role of ascorbic acid (AsA) in pituitary lactotroph and hypothalamic function. Plasma PRL concentrations of conscious AsA-deficient or control ODS rats were measured...
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| Veröffentlicht in: | Life sciences (1973) 1993, Vol.52 (11), p.975-979 |
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| container_title | Life sciences (1973) |
| container_volume | 52 |
| creator | Kawaguchi, Masanobu Hayakawa, Fuminori Kamiya, Yoshinobu Fujii, Toru Ito, Junko Sakuma, Nagahiko Fujinami, Takao |
| description | We examined the secretion of prolactin (PRL) in the hereditary scurvy-prone Osteogenic Disorder Shionogi (ODS) rat to investigate the role of ascorbic acid (AsA) in pituitary lactotroph and hypothalamic function. Plasma PRL concentrations of conscious AsA-deficient or control ODS rats were measured before and after the administration of metoclopramide (MCP), 5- hydroxy-L-tryptophan (5-HTP) or saline. The basal plasma PRL levels did not differ between the two groups. However, the AsA-deficient rats exhibited significantly larger changes in plasma prolactin concentration in response to MCP or 5-HTP than the control ODS rats. Thus, AsA deficiency enhanced the stimulated, but not the basal, secretion of PRL in ODS rats. Our findings suggest that AsA may have an inhibitory effect on PRL secretion. |
| doi_str_mv | 10.1016/0024-3205(93)90533-9 |
| format | Article |
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Plasma PRL concentrations of conscious AsA-deficient or control ODS rats were measured before and after the administration of metoclopramide (MCP), 5- hydroxy-L-tryptophan (5-HTP) or saline. The basal plasma PRL levels did not differ between the two groups. However, the AsA-deficient rats exhibited significantly larger changes in plasma prolactin concentration in response to MCP or 5-HTP than the control ODS rats. Thus, AsA deficiency enhanced the stimulated, but not the basal, secretion of PRL in ODS rats. 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Plasma PRL concentrations of conscious AsA-deficient or control ODS rats were measured before and after the administration of metoclopramide (MCP), 5- hydroxy-L-tryptophan (5-HTP) or saline. The basal plasma PRL levels did not differ between the two groups. However, the AsA-deficient rats exhibited significantly larger changes in plasma prolactin concentration in response to MCP or 5-HTP than the control ODS rats. Thus, AsA deficiency enhanced the stimulated, but not the basal, secretion of PRL in ODS rats. Our findings suggest that AsA may have an inhibitory effect on PRL secretion.</description><subject>5-Hydroxytryptophan - pharmacology</subject><subject>Animals</subject><subject>Ascorbic Acid - analysis</subject><subject>Ascorbic Acid Deficiency - metabolism</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Metoclopramide - pharmacology</subject><subject>Pituitary Gland - chemistry</subject><subject>Prolactin - blood</subject><subject>Prolactin - metabolism</subject><subject>Rats</subject><subject>Rats, Mutant Strains</subject><subject>Vertebrates: endocrinology</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1PHCEYx4lpo-u230ATDo3RwygMwwCXJo21rYmJB9szYeCZFTMLK7Ameus3L-tu9tgTL_-XPPxA6ISSS0pof0VI2zWsJfxcsQtFOGONOkAzKoVqSM_oBzTbW47Qcc5PhBDOBTtEh7LruJJyhv7ejCPYguOITbYxDd5iY73DMeCVL2tfTHrFqxQnY4sPOINNUHxV66E8Ag4xNNukKYDza6iX2b_5sMAxF4gLCLXS-RyTg4TzY83Ghcfn998fLnAy5RP6OJopw-fdOkd_ftz8vv7V3N3_vL3-dtdYRmhprCRStIJwM1BO21Yq1o9GOEtYZ8w4UGe5laYfjGWul8CpaXslnaBSctVKNkdn2976mOc15KKXPluYJhMgrrMWvGcVIq_Gbmu0KeacYNSr5JcVg6ZEb8jrDVa9waoV0-_k62aOTnf962EJbh_aoa76l51ecZlpTCZYn_e2ThAq3sf8urVBZfHiIelsPQQLzqf6UdpF__85_gEkXKCX</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Kawaguchi, Masanobu</creator><creator>Hayakawa, Fuminori</creator><creator>Kamiya, Yoshinobu</creator><creator>Fujii, Toru</creator><creator>Ito, Junko</creator><creator>Sakuma, Nagahiko</creator><creator>Fujinami, Takao</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Effect of ascorbic acid on pituitary prolactin secretion in the non-ascorbate synthesizing osteogenic disorder shionogi (ODS) rat</title><author>Kawaguchi, Masanobu ; Hayakawa, Fuminori ; Kamiya, Yoshinobu ; Fujii, Toru ; Ito, Junko ; Sakuma, Nagahiko ; Fujinami, Takao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-c80872705ab151228936fa7dc034aafb1dc5c8a6bac3d68e51a2698d718859283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>5-Hydroxytryptophan - pharmacology</topic><topic>Animals</topic><topic>Ascorbic Acid - analysis</topic><topic>Ascorbic Acid Deficiency - metabolism</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>Metoclopramide - pharmacology</topic><topic>Pituitary Gland - chemistry</topic><topic>Prolactin - blood</topic><topic>Prolactin - metabolism</topic><topic>Rats</topic><topic>Rats, Mutant Strains</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawaguchi, Masanobu</creatorcontrib><creatorcontrib>Hayakawa, Fuminori</creatorcontrib><creatorcontrib>Kamiya, Yoshinobu</creatorcontrib><creatorcontrib>Fujii, Toru</creatorcontrib><creatorcontrib>Ito, Junko</creatorcontrib><creatorcontrib>Sakuma, Nagahiko</creatorcontrib><creatorcontrib>Fujinami, Takao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawaguchi, Masanobu</au><au>Hayakawa, Fuminori</au><au>Kamiya, Yoshinobu</au><au>Fujii, Toru</au><au>Ito, Junko</au><au>Sakuma, Nagahiko</au><au>Fujinami, Takao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ascorbic acid on pituitary prolactin secretion in the non-ascorbate synthesizing osteogenic disorder shionogi (ODS) rat</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1993</date><risdate>1993</risdate><volume>52</volume><issue>11</issue><spage>975</spage><epage>979</epage><pages>975-979</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>We examined the secretion of prolactin (PRL) in the hereditary scurvy-prone Osteogenic Disorder Shionogi (ODS) rat to investigate the role of ascorbic acid (AsA) in pituitary lactotroph and hypothalamic function. Plasma PRL concentrations of conscious AsA-deficient or control ODS rats were measured before and after the administration of metoclopramide (MCP), 5- hydroxy-L-tryptophan (5-HTP) or saline. The basal plasma PRL levels did not differ between the two groups. However, the AsA-deficient rats exhibited significantly larger changes in plasma prolactin concentration in response to MCP or 5-HTP than the control ODS rats. Thus, AsA deficiency enhanced the stimulated, but not the basal, secretion of PRL in ODS rats. Our findings suggest that AsA may have an inhibitory effect on PRL secretion.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>8445988</pmid><doi>10.1016/0024-3205(93)90533-9</doi><tpages>5</tpages></addata></record> |
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| subjects | 5-Hydroxytryptophan - pharmacology Animals Ascorbic Acid - analysis Ascorbic Acid Deficiency - metabolism Biological and medical sciences Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Liver - chemistry Male Metoclopramide - pharmacology Pituitary Gland - chemistry Prolactin - blood Prolactin - metabolism Rats Rats, Mutant Strains Vertebrates: endocrinology |
| title | Effect of ascorbic acid on pituitary prolactin secretion in the non-ascorbate synthesizing osteogenic disorder shionogi (ODS) rat |
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