Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of life
Moraxella catarrhalis is an established bacterial pathogen, previously thought to be an innocent commensal of the respiratory tract of children and adults. The objective of this study was to identify significant risk factors associated with M. catarrhalis colonization in the first year of life in he...
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| Veröffentlicht in: | Clinical microbiology and infection 2010-07, Vol.16 (7), p.992-997 |
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| creator | Verhaegh, S.J.C. Lebon, A. Saarloos, J.A. Verbrugh, H.A. Jaddoe, V.W.V. Hofman, A. Hays, J.P. Moll, H.A. van Belkum, A. |
| description | Moraxella catarrhalis is an established bacterial pathogen, previously thought to be an innocent commensal of the respiratory tract of children and adults. The objective of this study was to identify significant risk factors associated with M. catarrhalis colonization in the first year of life in healthy Dutch children. This study investigated a target cohort group of 1079 children forming part of the Generation R Study, a population-based prospective cohort study following children from fetal life until young adulthood, conducted in Rotterdam, The Netherlands. Nasopharyngeal swabs for M. catarrhalis culture were obtained at 1.5, 6 and 14 months of age, with all three swabs being available for analyses from 443 children. Data on risk factors possibly associated with M. catarrhalis colonization were obtained by questionnaire at 2, 6 and 12 months. M. catarrhalis colonization increased from 11.8% at age 1.5 months to 29.9% and 29.7% at 6 and 14 months, respectively. Two significantly important colonization risk factors were found: the presence of siblings and day-care attendance, which both increased the risk of being positive for M. catarrhalis colonization on two or more occasions within the first year of life. Colonization with M. catarrhalis was not associated with gender, educational level of the mother, maternal smoking, breast-feeding, or antibiotic use. Apparently, crowding is an important risk factor for early and frequent colonization with M. catarrhalis in the first year of life. |
| doi_str_mv | 10.1111/j.1469-0691.2009.03008.x |
| format | Article |
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The objective of this study was to identify significant risk factors associated with M. catarrhalis colonization in the first year of life in healthy Dutch children. This study investigated a target cohort group of 1079 children forming part of the Generation R Study, a population-based prospective cohort study following children from fetal life until young adulthood, conducted in Rotterdam, The Netherlands. Nasopharyngeal swabs for M. catarrhalis culture were obtained at 1.5, 6 and 14 months of age, with all three swabs being available for analyses from 443 children. Data on risk factors possibly associated with M. catarrhalis colonization were obtained by questionnaire at 2, 6 and 12 months. M. catarrhalis colonization increased from 11.8% at age 1.5 months to 29.9% and 29.7% at 6 and 14 months, respectively. Two significantly important colonization risk factors were found: the presence of siblings and day-care attendance, which both increased the risk of being positive for M. catarrhalis colonization on two or more occasions within the first year of life. Colonization with M. catarrhalis was not associated with gender, educational level of the mother, maternal smoking, breast-feeding, or antibiotic use. Apparently, crowding is an important risk factor for early and frequent colonization with M. catarrhalis in the first year of life.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2009.03008.x</identifier><identifier>PMID: 19681950</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Age ; Age Distribution ; Antibiotics ; Child Day Care Centers ; Children ; Cohort Studies ; Colonization ; Commensals ; Crowding ; Data processing ; Environmental Exposure ; Female ; Fetuses ; Humans ; Infant ; Infant, Newborn ; Inventories ; Male ; Moraxella (Branhamella) catarrhalis - growth & development ; Moraxella (Branhamella) catarrhalis - isolation & purification ; Moraxella catarrhalis ; Nasopharynx - microbiology ; Netherlands ; pathogen ; Pathogens ; Respiratory tract ; Risk Factors ; Siblings ; Smoking ; Surveys and Questionnaires</subject><ispartof>Clinical microbiology and infection, 2010-07, Vol.16 (7), p.992-997</ispartof><rights>2010 European Society of Clinical Infectious Diseases</rights><rights>2009 The Authors. Journal Compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6038-58c957ce486dcba97bb3da204432280d83ebe6b14f13faae343288817f85ecca3</citedby><cites>FETCH-LOGICAL-c6038-58c957ce486dcba97bb3da204432280d83ebe6b14f13faae343288817f85ecca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1469-0691.2009.03008.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1469-0691.2009.03008.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19681950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verhaegh, S.J.C.</creatorcontrib><creatorcontrib>Lebon, A.</creatorcontrib><creatorcontrib>Saarloos, J.A.</creatorcontrib><creatorcontrib>Verbrugh, H.A.</creatorcontrib><creatorcontrib>Jaddoe, V.W.V.</creatorcontrib><creatorcontrib>Hofman, A.</creatorcontrib><creatorcontrib>Hays, J.P.</creatorcontrib><creatorcontrib>Moll, H.A.</creatorcontrib><creatorcontrib>van Belkum, A.</creatorcontrib><title>Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of life</title><title>Clinical microbiology and infection</title><addtitle>Clin Microbiol Infect</addtitle><description>Moraxella catarrhalis is an established bacterial pathogen, previously thought to be an innocent commensal of the respiratory tract of children and adults. The objective of this study was to identify significant risk factors associated with M. catarrhalis colonization in the first year of life in healthy Dutch children. This study investigated a target cohort group of 1079 children forming part of the Generation R Study, a population-based prospective cohort study following children from fetal life until young adulthood, conducted in Rotterdam, The Netherlands. Nasopharyngeal swabs for M. catarrhalis culture were obtained at 1.5, 6 and 14 months of age, with all three swabs being available for analyses from 443 children. Data on risk factors possibly associated with M. catarrhalis colonization were obtained by questionnaire at 2, 6 and 12 months. M. catarrhalis colonization increased from 11.8% at age 1.5 months to 29.9% and 29.7% at 6 and 14 months, respectively. Two significantly important colonization risk factors were found: the presence of siblings and day-care attendance, which both increased the risk of being positive for M. catarrhalis colonization on two or more occasions within the first year of life. Colonization with M. catarrhalis was not associated with gender, educational level of the mother, maternal smoking, breast-feeding, or antibiotic use. Apparently, crowding is an important risk factor for early and frequent colonization with M. catarrhalis in the first year of life.</description><subject>Age</subject><subject>Age Distribution</subject><subject>Antibiotics</subject><subject>Child Day Care Centers</subject><subject>Children</subject><subject>Cohort Studies</subject><subject>Colonization</subject><subject>Commensals</subject><subject>Crowding</subject><subject>Data processing</subject><subject>Environmental Exposure</subject><subject>Female</subject><subject>Fetuses</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inventories</subject><subject>Male</subject><subject>Moraxella (Branhamella) catarrhalis - growth & development</subject><subject>Moraxella (Branhamella) catarrhalis - isolation & purification</subject><subject>Moraxella catarrhalis</subject><subject>Nasopharynx - microbiology</subject><subject>Netherlands</subject><subject>pathogen</subject><subject>Pathogens</subject><subject>Respiratory tract</subject><subject>Risk Factors</subject><subject>Siblings</subject><subject>Smoking</subject><subject>Surveys and Questionnaires</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-P1SAUxYnROH_0KxgSF65aodAWFi70jY4mb-JGE3eE0lvLSwsj0PE9P7103osmbkY23MDvnMvlIIQpKWler3cl5Y0sSCNpWREiS8IIEeX-ETr_c_E411SKouXs2xm6iHFHCKkY40_RGZWNoLIm58hfQYIwW6dditgP-MYHvYdp0tjopEMY9WQjNn7yzv7SyXqHrcMj6CmNB3y1JDNiM9qpD-BwvwTrvuM0Ah5siAlTjmfv0nhvPdkBnqEng54iPD_tl-jrh_dfNh-L7efrT5u328I0hImiFkbWrQEumt50WrZdx3pdEc5ZVQnSCwYdNB3lA2WD1sDyuRCCtoOowRjNLtGro-9t8D8WiEnNNpp1Lgd-iaqtm0q2sqUPk7yWrGGkyeTLf8idX4LLYyharxQhtM2UOFIm-BgDDOo22FmHg6JErempnVpDUmtIak1P3aen9ln64tRg6Wbo_wpPcWXgzRH4aSc4_Lex2mxv1irr3x31kL_-zkJQ0VhwBnobwCTVe_vwK38DPMC97w</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Verhaegh, S.J.C.</creator><creator>Lebon, A.</creator><creator>Saarloos, J.A.</creator><creator>Verbrugh, H.A.</creator><creator>Jaddoe, V.W.V.</creator><creator>Hofman, A.</creator><creator>Hays, J.P.</creator><creator>Moll, H.A.</creator><creator>van Belkum, A.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of life</title><author>Verhaegh, S.J.C. ; Lebon, A. ; Saarloos, J.A. ; Verbrugh, H.A. ; Jaddoe, V.W.V. ; Hofman, A. ; Hays, J.P. ; Moll, H.A. ; van Belkum, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6038-58c957ce486dcba97bb3da204432280d83ebe6b14f13faae343288817f85ecca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age</topic><topic>Age Distribution</topic><topic>Antibiotics</topic><topic>Child Day Care Centers</topic><topic>Children</topic><topic>Cohort Studies</topic><topic>Colonization</topic><topic>Commensals</topic><topic>Crowding</topic><topic>Data processing</topic><topic>Environmental Exposure</topic><topic>Female</topic><topic>Fetuses</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Inventories</topic><topic>Male</topic><topic>Moraxella (Branhamella) catarrhalis - growth & development</topic><topic>Moraxella (Branhamella) catarrhalis - isolation & purification</topic><topic>Moraxella catarrhalis</topic><topic>Nasopharynx - microbiology</topic><topic>Netherlands</topic><topic>pathogen</topic><topic>Pathogens</topic><topic>Respiratory tract</topic><topic>Risk Factors</topic><topic>Siblings</topic><topic>Smoking</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verhaegh, S.J.C.</creatorcontrib><creatorcontrib>Lebon, A.</creatorcontrib><creatorcontrib>Saarloos, J.A.</creatorcontrib><creatorcontrib>Verbrugh, H.A.</creatorcontrib><creatorcontrib>Jaddoe, V.W.V.</creatorcontrib><creatorcontrib>Hofman, A.</creatorcontrib><creatorcontrib>Hays, J.P.</creatorcontrib><creatorcontrib>Moll, H.A.</creatorcontrib><creatorcontrib>van Belkum, A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical microbiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verhaegh, S.J.C.</au><au>Lebon, A.</au><au>Saarloos, J.A.</au><au>Verbrugh, H.A.</au><au>Jaddoe, V.W.V.</au><au>Hofman, A.</au><au>Hays, J.P.</au><au>Moll, H.A.</au><au>van Belkum, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of life</atitle><jtitle>Clinical microbiology and infection</jtitle><addtitle>Clin Microbiol Infect</addtitle><date>2010-07</date><risdate>2010</risdate><volume>16</volume><issue>7</issue><spage>992</spage><epage>997</epage><pages>992-997</pages><issn>1198-743X</issn><eissn>1469-0691</eissn><abstract>Moraxella catarrhalis is an established bacterial pathogen, previously thought to be an innocent commensal of the respiratory tract of children and adults. The objective of this study was to identify significant risk factors associated with M. catarrhalis colonization in the first year of life in healthy Dutch children. This study investigated a target cohort group of 1079 children forming part of the Generation R Study, a population-based prospective cohort study following children from fetal life until young adulthood, conducted in Rotterdam, The Netherlands. Nasopharyngeal swabs for M. catarrhalis culture were obtained at 1.5, 6 and 14 months of age, with all three swabs being available for analyses from 443 children. Data on risk factors possibly associated with M. catarrhalis colonization were obtained by questionnaire at 2, 6 and 12 months. M. catarrhalis colonization increased from 11.8% at age 1.5 months to 29.9% and 29.7% at 6 and 14 months, respectively. Two significantly important colonization risk factors were found: the presence of siblings and day-care attendance, which both increased the risk of being positive for M. catarrhalis colonization on two or more occasions within the first year of life. Colonization with M. catarrhalis was not associated with gender, educational level of the mother, maternal smoking, breast-feeding, or antibiotic use. Apparently, crowding is an important risk factor for early and frequent colonization with M. catarrhalis in the first year of life.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>19681950</pmid><doi>10.1111/j.1469-0691.2009.03008.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Age Distribution Antibiotics Child Day Care Centers Children Cohort Studies Colonization Commensals Crowding Data processing Environmental Exposure Female Fetuses Humans Infant Infant, Newborn Inventories Male Moraxella (Branhamella) catarrhalis - growth & development Moraxella (Branhamella) catarrhalis - isolation & purification Moraxella catarrhalis Nasopharynx - microbiology Netherlands pathogen Pathogens Respiratory tract Risk Factors Siblings Smoking Surveys and Questionnaires |
| title | Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of life |
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