Delays in Time to Treatment and Survival Impact in Breast Cancer
Background Time interval from diagnosis of breast cancer to treatment has been promulgated as one factor that can be used to evaluate cancer care quality. It remains controversial, however, whether a delay to treatment impacts survival. The purpose of this study was to evaluate whether delays from d...
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| Veröffentlicht in: | Annals of surgical oncology 2010-10, Vol.17 (Suppl 3), p.291-296 |
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| container_title | Annals of surgical oncology |
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| creator | Brazda, Amy Estroff, Jordan Euhus, David Leitch, A. Marilyn Huth, James Andrews, Valerie Moldrem, Amy Rao, Roshni |
| description | Background
Time interval from diagnosis of breast cancer to treatment has been promulgated as one factor that can be used to evaluate cancer care quality. It remains controversial, however, whether a delay to treatment impacts survival. The purpose of this study was to evaluate whether delays from diagnosis to initial treatment in breast cancer impacts survival.
Materials and Methods
A retrospective review of patients undergoing breast cancer treatment between August 2005 and December 2008 in a comprehensive, multidisciplinary breast oncology program was undertaken. Two hospital systems were included: a county hospital (CH) treating a primarily minority, indigent population and a university hospital (UH) treating a primarily Caucasian, insured population. Interval to treatment, calculated from date of diagnosis to surgery, chemotherapy, or radiation treatment, and overall survival was compared between the two groups.
Results
A total of 1337 patients were included; 634 patients were treated in the CH and 703 in the UH. Interval to treatment was longer in the CH compared with the UH (53.4 ± 2.0 vs 33.2 ± 1.2 days; mean ± standard error of the mean [SEM],
P
|
| doi_str_mv | 10.1245/s10434-010-1250-6 |
| format | Article |
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Time interval from diagnosis of breast cancer to treatment has been promulgated as one factor that can be used to evaluate cancer care quality. It remains controversial, however, whether a delay to treatment impacts survival. The purpose of this study was to evaluate whether delays from diagnosis to initial treatment in breast cancer impacts survival.
Materials and Methods
A retrospective review of patients undergoing breast cancer treatment between August 2005 and December 2008 in a comprehensive, multidisciplinary breast oncology program was undertaken. Two hospital systems were included: a county hospital (CH) treating a primarily minority, indigent population and a university hospital (UH) treating a primarily Caucasian, insured population. Interval to treatment, calculated from date of diagnosis to surgery, chemotherapy, or radiation treatment, and overall survival was compared between the two groups.
Results
A total of 1337 patients were included; 634 patients were treated in the CH and 703 in the UH. Interval to treatment was longer in the CH compared with the UH (53.4 ± 2.0 vs 33.2 ± 1.2 days; mean ± standard error of the mean [SEM],
P
< .0001). Patients treated at the CH had overall worse survival (
P
= .02); however, this difference did not hold true when controlled for stage. Additionally, when time to treatment was analyzed as an individual variable for all patients, there was no impact on survival.
Conclusions
Interval from diagnosis to treatment of breast cancer within the same cancer center was longer at the CH than the UH. There was, however, no effect on overall survival. Time to treatment may not be a meaningful indicator of cancer care quality.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-010-1250-6</identifier><identifier>PMID: 20853049</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>American Society of Breast Surgeons ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - mortality ; Breast Neoplasms - therapy ; Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Medicine ; Medicine & Public Health ; Neoplasm Staging ; Oncology ; Prognosis ; Retrospective Studies ; Surgery ; Surgical Oncology ; Survival Rate ; Time Factors</subject><ispartof>Annals of surgical oncology, 2010-10, Vol.17 (Suppl 3), p.291-296</ispartof><rights>Society of Surgical Oncology 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-96afc9a9065536d50b7f17048e635f6766923c86739f4d46235b59c95cfcbd0b3</citedby><cites>FETCH-LOGICAL-c484t-96afc9a9065536d50b7f17048e635f6766923c86739f4d46235b59c95cfcbd0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-010-1250-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-010-1250-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20853049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brazda, Amy</creatorcontrib><creatorcontrib>Estroff, Jordan</creatorcontrib><creatorcontrib>Euhus, David</creatorcontrib><creatorcontrib>Leitch, A. Marilyn</creatorcontrib><creatorcontrib>Huth, James</creatorcontrib><creatorcontrib>Andrews, Valerie</creatorcontrib><creatorcontrib>Moldrem, Amy</creatorcontrib><creatorcontrib>Rao, Roshni</creatorcontrib><title>Delays in Time to Treatment and Survival Impact in Breast Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Time interval from diagnosis of breast cancer to treatment has been promulgated as one factor that can be used to evaluate cancer care quality. It remains controversial, however, whether a delay to treatment impacts survival. The purpose of this study was to evaluate whether delays from diagnosis to initial treatment in breast cancer impacts survival.
Materials and Methods
A retrospective review of patients undergoing breast cancer treatment between August 2005 and December 2008 in a comprehensive, multidisciplinary breast oncology program was undertaken. Two hospital systems were included: a county hospital (CH) treating a primarily minority, indigent population and a university hospital (UH) treating a primarily Caucasian, insured population. Interval to treatment, calculated from date of diagnosis to surgery, chemotherapy, or radiation treatment, and overall survival was compared between the two groups.
Results
A total of 1337 patients were included; 634 patients were treated in the CH and 703 in the UH. Interval to treatment was longer in the CH compared with the UH (53.4 ± 2.0 vs 33.2 ± 1.2 days; mean ± standard error of the mean [SEM],
P
< .0001). Patients treated at the CH had overall worse survival (
P
= .02); however, this difference did not hold true when controlled for stage. Additionally, when time to treatment was analyzed as an individual variable for all patients, there was no impact on survival.
Conclusions
Interval from diagnosis to treatment of breast cancer within the same cancer center was longer at the CH than the UH. There was, however, no effect on overall survival. Time to treatment may not be a meaningful indicator of cancer care quality.</description><subject>American Society of Breast Surgeons</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - therapy</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Time Factors</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kMlOwzAQhi0EoqXwAFyQxYVTYLzGvgFlq1SJA-UcOY6DUmUpdlKpb49LWSQkTrN988_oR-iUwCWhXFwFApzxBAgkhApI5B4aExE7XCqyH3OQKtFUihE6CmEJQFIG4hCNKCjBgOsxur5ztdkEXLV4UTUO9x1eeGf6xrU9Nm2BXwa_rtamxrNmZWy_BW8jEHo8Na11_hgdlKYO7uQrTtDrw_1i-pTMnx9n05t5YrnifaKlKa02GqQQTBYC8rQkKXDlJBOlTKXUlFklU6ZLXnBJmciFtlrY0uYF5GyCLna6K9-9Dy70WVMF6-ratK4bQpYKSbVkqYrk-R9y2Q2-jc9FiKnoFJMRIjvI-i4E78ps5avG-E1GINuam-3MzeCzFpBtd86-hIe8ccXPxrebEaA7IMRR--b87-X_VT8AfwKBgQ</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Brazda, Amy</creator><creator>Estroff, Jordan</creator><creator>Euhus, David</creator><creator>Leitch, A. Marilyn</creator><creator>Huth, James</creator><creator>Andrews, Valerie</creator><creator>Moldrem, Amy</creator><creator>Rao, Roshni</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20101001</creationdate><title>Delays in Time to Treatment and Survival Impact in Breast Cancer</title><author>Brazda, Amy ; Estroff, Jordan ; Euhus, David ; Leitch, A. Marilyn ; Huth, James ; Andrews, Valerie ; Moldrem, Amy ; Rao, Roshni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-96afc9a9065536d50b7f17048e635f6766923c86739f4d46235b59c95cfcbd0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>American Society of Breast Surgeons</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - therapy</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brazda, Amy</creatorcontrib><creatorcontrib>Estroff, Jordan</creatorcontrib><creatorcontrib>Euhus, David</creatorcontrib><creatorcontrib>Leitch, A. Marilyn</creatorcontrib><creatorcontrib>Huth, James</creatorcontrib><creatorcontrib>Andrews, Valerie</creatorcontrib><creatorcontrib>Moldrem, Amy</creatorcontrib><creatorcontrib>Rao, Roshni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brazda, Amy</au><au>Estroff, Jordan</au><au>Euhus, David</au><au>Leitch, A. Marilyn</au><au>Huth, James</au><au>Andrews, Valerie</au><au>Moldrem, Amy</au><au>Rao, Roshni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delays in Time to Treatment and Survival Impact in Breast Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>17</volume><issue>Suppl 3</issue><spage>291</spage><epage>296</epage><pages>291-296</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Time interval from diagnosis of breast cancer to treatment has been promulgated as one factor that can be used to evaluate cancer care quality. It remains controversial, however, whether a delay to treatment impacts survival. The purpose of this study was to evaluate whether delays from diagnosis to initial treatment in breast cancer impacts survival.
Materials and Methods
A retrospective review of patients undergoing breast cancer treatment between August 2005 and December 2008 in a comprehensive, multidisciplinary breast oncology program was undertaken. Two hospital systems were included: a county hospital (CH) treating a primarily minority, indigent population and a university hospital (UH) treating a primarily Caucasian, insured population. Interval to treatment, calculated from date of diagnosis to surgery, chemotherapy, or radiation treatment, and overall survival was compared between the two groups.
Results
A total of 1337 patients were included; 634 patients were treated in the CH and 703 in the UH. Interval to treatment was longer in the CH compared with the UH (53.4 ± 2.0 vs 33.2 ± 1.2 days; mean ± standard error of the mean [SEM],
P
< .0001). Patients treated at the CH had overall worse survival (
P
= .02); however, this difference did not hold true when controlled for stage. Additionally, when time to treatment was analyzed as an individual variable for all patients, there was no impact on survival.
Conclusions
Interval from diagnosis to treatment of breast cancer within the same cancer center was longer at the CH than the UH. There was, however, no effect on overall survival. Time to treatment may not be a meaningful indicator of cancer care quality.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>20853049</pmid><doi>10.1245/s10434-010-1250-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2010-10, Vol.17 (Suppl 3), p.291-296 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_756296378 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | American Society of Breast Surgeons Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - mortality Breast Neoplasms - therapy Cohort Studies Female Follow-Up Studies Humans Medicine Medicine & Public Health Neoplasm Staging Oncology Prognosis Retrospective Studies Surgery Surgical Oncology Survival Rate Time Factors |
| title | Delays in Time to Treatment and Survival Impact in Breast Cancer |
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