Effects of Salicylate on Rectal Absorption of Theophylline

The rectal absorption of theophylline in rats was facilitated by concurrent administration of salicylic acid or sodium salicylate. The absorption of theophylline depended on the simultaneous absorption of salicylate and increased with an increasing concentration of salicylate. Calcium and magnesium...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1981-01, Vol.70 (1), p.71-75
Hauptverfasser:	Nishihata, Toshiaki, Rytting, J.Howard, Higuchi, Takeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Absorption, rectal—theophylline, effects of salicylate Animals Calcium - pharmacology effect of salicylate effects of salicylate Hydrogen-Ion Concentration Intestinal Absorption - drug effects Male Perfusion Rats rectal-theophylline Rectum - metabolism Salicylate-effect on rectal absorption of theophylline Salicylates - pharmacology Sodium Dodecyl Sulfate - pharmacology Theophylline - administration & dosage Theophylline - metabolism Theophylline-rectal absorption Theophylline—rectal absorption, effect of salicylate
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