Effects of Salicylate on Rectal Absorption of Theophylline
The rectal absorption of theophylline in rats was facilitated by concurrent administration of salicylic acid or sodium salicylate. The absorption of theophylline depended on the simultaneous absorption of salicylate and increased with an increasing concentration of salicylate. Calcium and magnesium...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical sciences 1981-01, Vol.70 (1), p.71-75 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 75 |
|---|---|
| container_issue | 1 |
| container_start_page | 71 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 70 |
| creator | Nishihata, Toshiaki Rytting, J.Howard Higuchi, Takeru |
| description | The rectal absorption of theophylline in rats was facilitated by concurrent administration of salicylic acid or sodium salicylate. The absorption of theophylline depended on the simultaneous absorption of salicylate and increased with an increasing concentration of salicylate. Calcium and magnesium ions inhibited the effects of salicylate at pH 7.4, but not at pH 4.5. Sodium lauryl sulfate caused lasting changes in rectal absorption, whereas the effects of salicylate on absorption were observed only when salicylate was present. Strong chelating agents, such as ethylenediaminetetraacetic acid and sodium citrate did not affect the absorption of theophylline, except at very high concentrations (30%), where membrane damage was observed. Rectal drug absorption was not enhanced by vasodilation or inflammation alone since sodium nicotinate and histamine did not facilitate the disappearance of theophylline from the perfusate. |
| doi_str_mv | 10.1002/jps.2600700114 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_75628858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022354915435543</els_id><sourcerecordid>75628858</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4274-e64a48b647030756806b148c5a121e2c3d58ca441a6651285f9852975991abf73</originalsourceid><addsrcrecordid>eNqFkU1v1DAQhq0KVJbSKzeknLhlGTv-7K2qyhaoWtQP9Wg53onq1rsJdha6_x5XWRVxQJwszTzvI_kdQt5TmFMA9ulhyHMmARQApXyPzKhgUEug6hWZFYDVjeDmDXmb8wMASBBin-wrxoxp-IwcnXYd-jFXfVdduxj8NroRq35dXZWxi9Vxm_s0jKFMCnJzj_1wv40xrPEded25mPFw9x6Q28-nNydn9fnl4svJ8XntOVO8Rskd163kChpQQmqQLeXaC0cZReabpdDecU6dlIIyLTqjBTNKGENd26nmgHycvEPqf2wwj3YVsscY3Rr7TbbFybQWuoDzCfSpzzlhZ4cUVi5tLQX7XJYtZdk_ZZXAh515065w-YLv2il7M-1_hYjb_9js1-_Xf7nrKRvyiE8vWZcerVSNEvbuYmEZE4sr9u3CmsLricdS5c-AyWYfcO1xGVK5hF324V_f-A2sv5S5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>75628858</pqid></control><display><type>article</type><title>Effects of Salicylate on Rectal Absorption of Theophylline</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Nishihata, Toshiaki ; Rytting, J.Howard ; Higuchi, Takeru</creator><creatorcontrib>Nishihata, Toshiaki ; Rytting, J.Howard ; Higuchi, Takeru</creatorcontrib><description>The rectal absorption of theophylline in rats was facilitated by concurrent administration of salicylic acid or sodium salicylate. The absorption of theophylline depended on the simultaneous absorption of salicylate and increased with an increasing concentration of salicylate. Calcium and magnesium ions inhibited the effects of salicylate at pH 7.4, but not at pH 4.5. Sodium lauryl sulfate caused lasting changes in rectal absorption, whereas the effects of salicylate on absorption were observed only when salicylate was present. Strong chelating agents, such as ethylenediaminetetraacetic acid and sodium citrate did not affect the absorption of theophylline, except at very high concentrations (30%), where membrane damage was observed. Rectal drug absorption was not enhanced by vasodilation or inflammation alone since sodium nicotinate and histamine did not facilitate the disappearance of theophylline from the perfusate.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600700114</identifier><identifier>PMID: 7229934</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Absorption ; Absorption, rectal—theophylline, effects of salicylate ; Animals ; Calcium - pharmacology ; effect of salicylate ; effects of salicylate ; Hydrogen-Ion Concentration ; Intestinal Absorption - drug effects ; Male ; Perfusion ; Rats ; rectal-theophylline ; Rectum - metabolism ; Salicylate-effect on rectal absorption of theophylline ; Salicylates - pharmacology ; Sodium Dodecyl Sulfate - pharmacology ; Theophylline - administration & dosage ; Theophylline - metabolism ; Theophylline-rectal absorption ; Theophylline—rectal absorption, effect of salicylate</subject><ispartof>Journal of pharmaceutical sciences, 1981-01, Vol.70 (1), p.71-75</ispartof><rights>1981 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1981 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4274-e64a48b647030756806b148c5a121e2c3d58ca441a6651285f9852975991abf73</citedby><cites>FETCH-LOGICAL-c4274-e64a48b647030756806b148c5a121e2c3d58ca441a6651285f9852975991abf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600700114$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600700114$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7229934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishihata, Toshiaki</creatorcontrib><creatorcontrib>Rytting, J.Howard</creatorcontrib><creatorcontrib>Higuchi, Takeru</creatorcontrib><title>Effects of Salicylate on Rectal Absorption of Theophylline</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>The rectal absorption of theophylline in rats was facilitated by concurrent administration of salicylic acid or sodium salicylate. The absorption of theophylline depended on the simultaneous absorption of salicylate and increased with an increasing concentration of salicylate. Calcium and magnesium ions inhibited the effects of salicylate at pH 7.4, but not at pH 4.5. Sodium lauryl sulfate caused lasting changes in rectal absorption, whereas the effects of salicylate on absorption were observed only when salicylate was present. Strong chelating agents, such as ethylenediaminetetraacetic acid and sodium citrate did not affect the absorption of theophylline, except at very high concentrations (30%), where membrane damage was observed. Rectal drug absorption was not enhanced by vasodilation or inflammation alone since sodium nicotinate and histamine did not facilitate the disappearance of theophylline from the perfusate.</description><subject>Absorption</subject><subject>Absorption, rectal—theophylline, effects of salicylate</subject><subject>Animals</subject><subject>Calcium - pharmacology</subject><subject>effect of salicylate</subject><subject>effects of salicylate</subject><subject>Hydrogen-Ion Concentration</subject><subject>Intestinal Absorption - drug effects</subject><subject>Male</subject><subject>Perfusion</subject><subject>Rats</subject><subject>rectal-theophylline</subject><subject>Rectum - metabolism</subject><subject>Salicylate-effect on rectal absorption of theophylline</subject><subject>Salicylates - pharmacology</subject><subject>Sodium Dodecyl Sulfate - pharmacology</subject><subject>Theophylline - administration & dosage</subject><subject>Theophylline - metabolism</subject><subject>Theophylline-rectal absorption</subject><subject>Theophylline—rectal absorption, effect of salicylate</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhq0KVJbSKzeknLhlGTv-7K2qyhaoWtQP9Wg53onq1rsJdha6_x5XWRVxQJwszTzvI_kdQt5TmFMA9ulhyHMmARQApXyPzKhgUEug6hWZFYDVjeDmDXmb8wMASBBin-wrxoxp-IwcnXYd-jFXfVdduxj8NroRq35dXZWxi9Vxm_s0jKFMCnJzj_1wv40xrPEded25mPFw9x6Q28-nNydn9fnl4svJ8XntOVO8Rskd163kChpQQmqQLeXaC0cZReabpdDecU6dlIIyLTqjBTNKGENd26nmgHycvEPqf2wwj3YVsscY3Rr7TbbFybQWuoDzCfSpzzlhZ4cUVi5tLQX7XJYtZdk_ZZXAh515065w-YLv2il7M-1_hYjb_9js1-_Xf7nrKRvyiE8vWZcerVSNEvbuYmEZE4sr9u3CmsLricdS5c-AyWYfcO1xGVK5hF324V_f-A2sv5S5</recordid><startdate>198101</startdate><enddate>198101</enddate><creator>Nishihata, Toshiaki</creator><creator>Rytting, J.Howard</creator><creator>Higuchi, Takeru</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198101</creationdate><title>Effects of Salicylate on Rectal Absorption of Theophylline</title><author>Nishihata, Toshiaki ; Rytting, J.Howard ; Higuchi, Takeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4274-e64a48b647030756806b148c5a121e2c3d58ca441a6651285f9852975991abf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Absorption</topic><topic>Absorption, rectal—theophylline, effects of salicylate</topic><topic>Animals</topic><topic>Calcium - pharmacology</topic><topic>effect of salicylate</topic><topic>effects of salicylate</topic><topic>Hydrogen-Ion Concentration</topic><topic>Intestinal Absorption - drug effects</topic><topic>Male</topic><topic>Perfusion</topic><topic>Rats</topic><topic>rectal-theophylline</topic><topic>Rectum - metabolism</topic><topic>Salicylate-effect on rectal absorption of theophylline</topic><topic>Salicylates - pharmacology</topic><topic>Sodium Dodecyl Sulfate - pharmacology</topic><topic>Theophylline - administration & dosage</topic><topic>Theophylline - metabolism</topic><topic>Theophylline-rectal absorption</topic><topic>Theophylline—rectal absorption, effect of salicylate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishihata, Toshiaki</creatorcontrib><creatorcontrib>Rytting, J.Howard</creatorcontrib><creatorcontrib>Higuchi, Takeru</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishihata, Toshiaki</au><au>Rytting, J.Howard</au><au>Higuchi, Takeru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Salicylate on Rectal Absorption of Theophylline</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1981-01</date><risdate>1981</risdate><volume>70</volume><issue>1</issue><spage>71</spage><epage>75</epage><pages>71-75</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>The rectal absorption of theophylline in rats was facilitated by concurrent administration of salicylic acid or sodium salicylate. The absorption of theophylline depended on the simultaneous absorption of salicylate and increased with an increasing concentration of salicylate. Calcium and magnesium ions inhibited the effects of salicylate at pH 7.4, but not at pH 4.5. Sodium lauryl sulfate caused lasting changes in rectal absorption, whereas the effects of salicylate on absorption were observed only when salicylate was present. Strong chelating agents, such as ethylenediaminetetraacetic acid and sodium citrate did not affect the absorption of theophylline, except at very high concentrations (30%), where membrane damage was observed. Rectal drug absorption was not enhanced by vasodilation or inflammation alone since sodium nicotinate and histamine did not facilitate the disappearance of theophylline from the perfusate.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7229934</pmid><doi>10.1002/jps.2600700114</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1981-01, Vol.70 (1), p.71-75 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75628858 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Absorption Absorption, rectal—theophylline, effects of salicylate Animals Calcium - pharmacology effect of salicylate effects of salicylate Hydrogen-Ion Concentration Intestinal Absorption - drug effects Male Perfusion Rats rectal-theophylline Rectum - metabolism Salicylate-effect on rectal absorption of theophylline Salicylates - pharmacology Sodium Dodecyl Sulfate - pharmacology Theophylline - administration & dosage Theophylline - metabolism Theophylline-rectal absorption Theophylline—rectal absorption, effect of salicylate |
| title | Effects of Salicylate on Rectal Absorption of Theophylline |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T12%3A39%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Salicylate%20on%20Rectal%20Absorption%20of%20Theophylline&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Nishihata,%20Toshiaki&rft.date=1981-01&rft.volume=70&rft.issue=1&rft.spage=71&rft.epage=75&rft.pages=71-75&rft.issn=0022-3549&rft.eissn=1520-6017&rft_id=info:doi/10.1002/jps.2600700114&rft_dat=%3Cproquest_cross%3E75628858%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=75628858&rft_id=info:pmid/7229934&rft_els_id=S0022354915435543&rfr_iscdi=true |