Hemodynamic effects of nipradilol, a new β-adrenergic antagonist combined with a nitroxy base, in rats with intra- or extra-hepatic portal hypertension
It has been demonstrated that β-adrenergic antagonists and nitrovasodilators reduce portal pressure in patients with portal hypertension. Thus, the hemodynamic effects of nipradilol, a new β-adrenergic antagonist combined with a nitroxy base, was studied in conscious and unrestrained rats in two mod...
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| Veröffentlicht in: | Journal of hepatology 1993, Vol.17 (2), p.236-240 |
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| creator | Ohsuga, Masaru Cailmail, Stéphane Lebrec, Didier |
| description | It has been demonstrated that
β-adrenergic antagonists and nitrovasodilators reduce portal pressure in patients with portal hypertension. Thus, the hemodynamic effects of nipradilol, a new
β-adrenergic antagonist combined with a nitroxy base, was studied in conscious and unrestrained rats in two models of portal hypertension. The hemodynamic effects were compared to those obtained after propranolol administration. Both nipradilol (20 mg/kg) and propranolol (20 mg/kg) significantly decreased portal pressure in both groups of portal hypertensive rats. In cirrhotic rats, nipradilol decreased portal pressure (−24 ± 2%) more than propranolol (−9 ± 2%). Both nipradilol and propranolol significantly decreased portal tributary blood flow and cardiac index in both groups. Changes in portal tributary blood flow and cardiac index were not significantly different between nipradilol and propranolol. Propranolol, but not nipradilol significantly increased hepatocollateral resistance in cirrhotic rats but not in portal vein stenosed rats. Thus, the marked reduction of portal pressure after nipradilol administration depends in part on a limited increase in hepatocollateral resistance. Nipradilol significantly decreased mean arterial pressure, while propranolol did not change this value in either groups. In conclusion, nipradilol markedly decreased portal pressure in rats with portal hypertension. This beneficial effect suggests that nipradilol should be tested in the patients with portal hypertension. |
| doi_str_mv | 10.1016/S0168-8278(05)80044-3 |
| format | Article |
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β-adrenergic antagonists and nitrovasodilators reduce portal pressure in patients with portal hypertension. Thus, the hemodynamic effects of nipradilol, a new
β-adrenergic antagonist combined with a nitroxy base, was studied in conscious and unrestrained rats in two models of portal hypertension. The hemodynamic effects were compared to those obtained after propranolol administration. Both nipradilol (20 mg/kg) and propranolol (20 mg/kg) significantly decreased portal pressure in both groups of portal hypertensive rats. In cirrhotic rats, nipradilol decreased portal pressure (−24 ± 2%) more than propranolol (−9 ± 2%). Both nipradilol and propranolol significantly decreased portal tributary blood flow and cardiac index in both groups. Changes in portal tributary blood flow and cardiac index were not significantly different between nipradilol and propranolol. Propranolol, but not nipradilol significantly increased hepatocollateral resistance in cirrhotic rats but not in portal vein stenosed rats. Thus, the marked reduction of portal pressure after nipradilol administration depends in part on a limited increase in hepatocollateral resistance. Nipradilol significantly decreased mean arterial pressure, while propranolol did not change this value in either groups. In conclusion, nipradilol markedly decreased portal pressure in rats with portal hypertension. This beneficial effect suggests that nipradilol should be tested in the patients with portal hypertension.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/S0168-8278(05)80044-3</identifier><identifier>PMID: 8095275</identifier><identifier>CODEN: JOHEEC</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Adrenergic beta-Antagonists - pharmacology ; Animals ; Antihypertensive agents ; Biological and medical sciences ; Blood Circulation - drug effects ; Cardiac output ; Cardiovascular system ; Cirrhosis ; Hemodynamic ; Hemodynamics - drug effects ; Hypertension, Portal - drug therapy ; Hypertension, Portal - physiopathology ; Male ; Medical sciences ; Nitrovasodilatation ; Pharmaceutical Vehicles ; Pharmacology. Drug treatments ; Portal pressure ; Propanolamines - pharmacology ; Propranolol ; Propranolol - pharmacology ; Rats ; Rats, Sprague-Dawley ; Splanchnic ; Splanchnic Circulation - drug effects</subject><ispartof>Journal of hepatology, 1993, Vol.17 (2), p.236-240</ispartof><rights>1993 Elsevier Scientific Publishers Ireland Ltd. All rights reserved</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c304t-f175455ff8195a957f2b1d7beab73902faccc99d42a35c39bdda896f58b871c63</citedby><cites>FETCH-LOGICAL-c304t-f175455ff8195a957f2b1d7beab73902faccc99d42a35c39bdda896f58b871c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8278(05)80044-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,4012,27906,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4671004$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8095275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohsuga, Masaru</creatorcontrib><creatorcontrib>Cailmail, Stéphane</creatorcontrib><creatorcontrib>Lebrec, Didier</creatorcontrib><title>Hemodynamic effects of nipradilol, a new β-adrenergic antagonist combined with a nitroxy base, in rats with intra- or extra-hepatic portal hypertension</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>It has been demonstrated that
β-adrenergic antagonists and nitrovasodilators reduce portal pressure in patients with portal hypertension. Thus, the hemodynamic effects of nipradilol, a new
β-adrenergic antagonist combined with a nitroxy base, was studied in conscious and unrestrained rats in two models of portal hypertension. The hemodynamic effects were compared to those obtained after propranolol administration. Both nipradilol (20 mg/kg) and propranolol (20 mg/kg) significantly decreased portal pressure in both groups of portal hypertensive rats. In cirrhotic rats, nipradilol decreased portal pressure (−24 ± 2%) more than propranolol (−9 ± 2%). Both nipradilol and propranolol significantly decreased portal tributary blood flow and cardiac index in both groups. Changes in portal tributary blood flow and cardiac index were not significantly different between nipradilol and propranolol. Propranolol, but not nipradilol significantly increased hepatocollateral resistance in cirrhotic rats but not in portal vein stenosed rats. Thus, the marked reduction of portal pressure after nipradilol administration depends in part on a limited increase in hepatocollateral resistance. Nipradilol significantly decreased mean arterial pressure, while propranolol did not change this value in either groups. In conclusion, nipradilol markedly decreased portal pressure in rats with portal hypertension. This beneficial effect suggests that nipradilol should be tested in the patients with portal hypertension.</description><subject>Adrenergic beta-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Blood Circulation - drug effects</subject><subject>Cardiac output</subject><subject>Cardiovascular system</subject><subject>Cirrhosis</subject><subject>Hemodynamic</subject><subject>Hemodynamics - drug effects</subject><subject>Hypertension, Portal - drug therapy</subject><subject>Hypertension, Portal - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitrovasodilatation</subject><subject>Pharmaceutical Vehicles</subject><subject>Pharmacology. Drug treatments</subject><subject>Portal pressure</subject><subject>Propanolamines - pharmacology</subject><subject>Propranolol</subject><subject>Propranolol - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Splanchnic</subject><subject>Splanchnic Circulation - drug effects</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EKkvhESr5gBBIDdhJHCenClVAkSpxAM7WxB53jRI72F7afROegwfhmfD-0V65jEf6fvONNR8hF5y95Yx3776W0ld9LfvXTLzpGWvbqnlEVrxjrGJdyx-T1Ql5Sp6l9IMx1rChPSNnPRtELcWK_L7BOZith9lpitaizokGS71bIhg3hemSAvV4T__-qcBE9BjvCgo-w13wLmWqwzw6j4beu7zewS7H8LClIyS8pM7TCMVzLzqfI1Q0RIoPu26NC-TitoSYYaLr7YIxo08u-OfkiYUp4Yvje06-f_zw7fqmuv3y6fP1-9tKN6zNleVStEJY2_NBwCCkrUdu5IgwymZgtQWt9TCYtoZG6GYYjYF-6Kzox15y3TXn5NXBd4nh5wZTVrNLGqcJPIZNUlJ0dVfXrIDiAOoYUopo1RLdDHGrOFO7RNQ-EbU7t2JC7RNRTZm7OC7YjDOa09QxgqK_POqQNEw2gtcunbC2k7w4FezqgGE5xi-HUSXt0Gs0LpbQlAnuPx_5Bzb6q48</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Ohsuga, Masaru</creator><creator>Cailmail, Stéphane</creator><creator>Lebrec, Didier</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Hemodynamic effects of nipradilol, a new β-adrenergic antagonist combined with a nitroxy base, in rats with intra- or extra-hepatic portal hypertension</title><author>Ohsuga, Masaru ; Cailmail, Stéphane ; Lebrec, Didier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c304t-f175455ff8195a957f2b1d7beab73902faccc99d42a35c39bdda896f58b871c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adrenergic beta-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Biological and medical sciences</topic><topic>Blood Circulation - drug effects</topic><topic>Cardiac output</topic><topic>Cardiovascular system</topic><topic>Cirrhosis</topic><topic>Hemodynamic</topic><topic>Hemodynamics - drug effects</topic><topic>Hypertension, Portal - drug therapy</topic><topic>Hypertension, Portal - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitrovasodilatation</topic><topic>Pharmaceutical Vehicles</topic><topic>Pharmacology. Drug treatments</topic><topic>Portal pressure</topic><topic>Propanolamines - pharmacology</topic><topic>Propranolol</topic><topic>Propranolol - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Splanchnic</topic><topic>Splanchnic Circulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohsuga, Masaru</creatorcontrib><creatorcontrib>Cailmail, Stéphane</creatorcontrib><creatorcontrib>Lebrec, Didier</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohsuga, Masaru</au><au>Cailmail, Stéphane</au><au>Lebrec, Didier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemodynamic effects of nipradilol, a new β-adrenergic antagonist combined with a nitroxy base, in rats with intra- or extra-hepatic portal hypertension</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>1993</date><risdate>1993</risdate><volume>17</volume><issue>2</issue><spage>236</spage><epage>240</epage><pages>236-240</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><coden>JOHEEC</coden><abstract>It has been demonstrated that
β-adrenergic antagonists and nitrovasodilators reduce portal pressure in patients with portal hypertension. Thus, the hemodynamic effects of nipradilol, a new
β-adrenergic antagonist combined with a nitroxy base, was studied in conscious and unrestrained rats in two models of portal hypertension. The hemodynamic effects were compared to those obtained after propranolol administration. Both nipradilol (20 mg/kg) and propranolol (20 mg/kg) significantly decreased portal pressure in both groups of portal hypertensive rats. In cirrhotic rats, nipradilol decreased portal pressure (−24 ± 2%) more than propranolol (−9 ± 2%). Both nipradilol and propranolol significantly decreased portal tributary blood flow and cardiac index in both groups. Changes in portal tributary blood flow and cardiac index were not significantly different between nipradilol and propranolol. Propranolol, but not nipradilol significantly increased hepatocollateral resistance in cirrhotic rats but not in portal vein stenosed rats. Thus, the marked reduction of portal pressure after nipradilol administration depends in part on a limited increase in hepatocollateral resistance. Nipradilol significantly decreased mean arterial pressure, while propranolol did not change this value in either groups. In conclusion, nipradilol markedly decreased portal pressure in rats with portal hypertension. This beneficial effect suggests that nipradilol should be tested in the patients with portal hypertension.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>8095275</pmid><doi>10.1016/S0168-8278(05)80044-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of hepatology, 1993, Vol.17 (2), p.236-240 |
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| subjects | Adrenergic beta-Antagonists - pharmacology Animals Antihypertensive agents Biological and medical sciences Blood Circulation - drug effects Cardiac output Cardiovascular system Cirrhosis Hemodynamic Hemodynamics - drug effects Hypertension, Portal - drug therapy Hypertension, Portal - physiopathology Male Medical sciences Nitrovasodilatation Pharmaceutical Vehicles Pharmacology. Drug treatments Portal pressure Propanolamines - pharmacology Propranolol Propranolol - pharmacology Rats Rats, Sprague-Dawley Splanchnic Splanchnic Circulation - drug effects |
| title | Hemodynamic effects of nipradilol, a new β-adrenergic antagonist combined with a nitroxy base, in rats with intra- or extra-hepatic portal hypertension |
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