A denaturing gradient gel electrophoresis assay for sensitive detection of p53 mutations

p53 is a tumor suppressor gene located on 17p, a region of the human genome frequently deleted in tumors. Mutation of the p53 gene is an important step leading to development of many forms of human cancer. To simplify the analysis of tumors for p53 point mutations, we describe a GC-clamped denaturin...

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Veröffentlicht in:	Human genetics 1993-03, Vol.91 (1), p.25-30
Hauptverfasser:	BECK, J. S, KWITEK, A. E, COGEN, P. H, METZGER, A. K, DUYK, G. M, SHEFFIELD, V. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Electrophoresis, Gel, Pulsed-Field - methods General aspects Genes, p53 - genetics Humans Medical sciences Molecular Sequence Data Point Mutation - genetics Tumors
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