Cytokeratin expression in oral cancer and its relationship to tumor differentiation
Although cytokeratin expression is said to alter with the state of tumor differentiation, few studies appear to have confirmed this in fresh tissues biopsies from oral squamous cell carcinomas. Previous studies have been limited by the number of antibodies utilized, small sample size, or lack of inf...
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| Veröffentlicht in: | Journal of oral pathology & medicine 1993-02, Vol.22 (2), p.82-86 |
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| container_title | Journal of oral pathology & medicine |
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| creator | Ogden, Graham R. Chisholm, Derrick M. Adi, Mohammed Lane, E. Birgitte |
| description | Although cytokeratin expression is said to alter with the state of tumor differentiation, few studies appear to have confirmed this in fresh tissues biopsies from oral squamous cell carcinomas. Previous studies have been limited by the number of antibodies utilized, small sample size, or lack of information regarding tumor differentiation. A panel of 8 antikeratin antibodies (of which five recognised the simple epithelial karatins, 8. 18 and 19) were applied to fresh tissue biopsies from 24 oral cancer and 15 normal oral mucosal biopsies. A standard immunocytochemical technique was followed (Vectastain Abc Method), with keratin expression graded on a 3 point scale. Our analysis indicated that simple epithelial keratins (K8. K.I8, K19) were not confined to the more poorly differentiated tumors. This may be relevant to tumor prognosis. |
| doi_str_mv | 10.1111/j.1600-0714.1993.tb00049.x |
| format | Article |
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Birgitte</creatorcontrib><title>Cytokeratin expression in oral cancer and its relationship to tumor differentiation</title><title>Journal of oral pathology & medicine</title><addtitle>J Oral Pathol Med</addtitle><description>Although cytokeratin expression is said to alter with the state of tumor differentiation, few studies appear to have confirmed this in fresh tissues biopsies from oral squamous cell carcinomas. Previous studies have been limited by the number of antibodies utilized, small sample size, or lack of information regarding tumor differentiation. A panel of 8 antikeratin antibodies (of which five recognised the simple epithelial karatins, 8. 18 and 19) were applied to fresh tissue biopsies from 24 oral cancer and 15 normal oral mucosal biopsies. A standard immunocytochemical technique was followed (Vectastain Abc Method), with keratin expression graded on a 3 point scale. Our analysis indicated that simple epithelial keratins (K8. K.I8, K19) were not confined to the more poorly differentiated tumors. This may be relevant to tumor prognosis.</description><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor</subject><subject>Carcinoma, Squamous Cell - chemistry</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>cytokeratins</subject><subject>Dentistry</subject><subject>Ent. Stomatology</subject><subject>epithelial differentiation</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keratins - analysis</subject><subject>Keratins - immunology</subject><subject>Keratins - metabolism</subject><subject>Medical sciences</subject><subject>Mouth Neoplasms - chemistry</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasm Proteins - metabolism</subject><subject>oral cancer</subject><subject>oral mucosa</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><issn>0904-2512</issn><issn>1600-0714</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1v2yAYhdG0qUvb_YRJqJp2ZxeMMfakXUxZP1W1q9aql-g1BpXUMRkQNfn3xY2V-3ED6JzzwnkQOqEkp2mdLnJaEZIRQcucNg3LY0sIKZt88wHN9tJHNCMNKbOC0-IzOgxhQQgVrKQH6EBUNWFCzNDf-Ta6F-0h2gHrzcrrEKwbcLo5Dz1WMCjtMQwdtjFgr_vkdEN4tiscHY7rpfO4s8Zor4do38Vj9MlAH_SXaT9Cj-dnD_PL7Obu4mr-6yZTnNAiY0SDAMZVR7sCGDBjWDqKirZtW3ZlKmagKBWYhmvCUgvgdV2rlG5a3ih2hL7v5q68-7fWIcqlDUr3PQzarYMUvCo4K4pk_LEzKu9C8NrIlbdL8FtJiRyJyoUcsckRmxyJyomo3KTw1-mVdbvU3T46IUz6t0mHoKA3PhGzYW8rK87qmifbz53t1fZ6-x8fkNd3f-qxQ7bL2xD1Zp8H_yIrwQSXT7cX8p7-fqpu-b18YG-lA6MI</recordid><startdate>199302</startdate><enddate>199302</enddate><creator>Ogden, Graham R.</creator><creator>Chisholm, Derrick M.</creator><creator>Adi, Mohammed</creator><creator>Lane, E. Birgitte</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199302</creationdate><title>Cytokeratin expression in oral cancer and its relationship to tumor differentiation</title><author>Ogden, Graham R. ; Chisholm, Derrick M. ; Adi, Mohammed ; Lane, E. Birgitte</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5012-30ea7a35cd1d2a3a3ff3d1d761bbb4d4993fa24caf95e03512a5888cc509b59c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor</topic><topic>Carcinoma, Squamous Cell - chemistry</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>cytokeratins</topic><topic>Dentistry</topic><topic>Ent. Stomatology</topic><topic>epithelial differentiation</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Keratins - analysis</topic><topic>Keratins - immunology</topic><topic>Keratins - metabolism</topic><topic>Medical sciences</topic><topic>Mouth Neoplasms - chemistry</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasm Proteins - metabolism</topic><topic>oral cancer</topic><topic>oral mucosa</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogden, Graham R.</creatorcontrib><creatorcontrib>Chisholm, Derrick M.</creatorcontrib><creatorcontrib>Adi, Mohammed</creatorcontrib><creatorcontrib>Lane, E. Birgitte</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of oral pathology & medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogden, Graham R.</au><au>Chisholm, Derrick M.</au><au>Adi, Mohammed</au><au>Lane, E. Birgitte</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokeratin expression in oral cancer and its relationship to tumor differentiation</atitle><jtitle>Journal of oral pathology & medicine</jtitle><addtitle>J Oral Pathol Med</addtitle><date>1993-02</date><risdate>1993</risdate><volume>22</volume><issue>2</issue><spage>82</spage><epage>86</epage><pages>82-86</pages><issn>0904-2512</issn><eissn>1600-0714</eissn><abstract>Although cytokeratin expression is said to alter with the state of tumor differentiation, few studies appear to have confirmed this in fresh tissues biopsies from oral squamous cell carcinomas. Previous studies have been limited by the number of antibodies utilized, small sample size, or lack of information regarding tumor differentiation. A panel of 8 antikeratin antibodies (of which five recognised the simple epithelial karatins, 8. 18 and 19) were applied to fresh tissue biopsies from 24 oral cancer and 15 normal oral mucosal biopsies. A standard immunocytochemical technique was followed (Vectastain Abc Method), with keratin expression graded on a 3 point scale. Our analysis indicated that simple epithelial keratins (K8. K.I8, K19) were not confined to the more poorly differentiated tumors. This may be relevant to tumor prognosis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7680377</pmid><doi>10.1111/j.1600-0714.1993.tb00049.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of oral pathology & medicine, 1993-02, Vol.22 (2), p.82-86 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antibodies, Monoclonal Biological and medical sciences Biomarkers, Tumor Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - pathology cytokeratins Dentistry Ent. Stomatology epithelial differentiation Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Keratins - analysis Keratins - immunology Keratins - metabolism Medical sciences Mouth Neoplasms - chemistry Mouth Neoplasms - pathology Neoplasm Proteins - analysis Neoplasm Proteins - metabolism oral cancer oral mucosa Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis |
| title | Cytokeratin expression in oral cancer and its relationship to tumor differentiation |
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