Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin
Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated...
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Veröffentlicht in: | Inflammation 1981-03, Vol.5 (1), p.55-60 |
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creator | Cushing, A H Murphy, S Skipper, B E |
description | Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested. |
doi_str_mv | 10.1007/BF00910779 |
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Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested.</description><identifier>ISSN: 0360-3997</identifier><identifier>DOI: 10.1007/BF00910779</identifier><identifier>PMID: 6262237</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Ascitic Fluid - cytology ; Chemotaxis ; Cyclic AMP ; Escherichia coli - immunology ; Hot Temperature ; Macrophage Migration-Inhibitory Factors - pharmacology ; Rabbits ; Toxins, Biological - pharmacology</subject><ispartof>Inflammation, 1981-03, Vol.5 (1), p.55-60</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6262237$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cushing, A H</creatorcontrib><creatorcontrib>Murphy, S</creatorcontrib><creatorcontrib>Skipper, B E</creatorcontrib><title>Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin</title><title>Inflammation</title><addtitle>Inflammation</addtitle><description>Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested.</description><subject>Animals</subject><subject>Ascitic Fluid - cytology</subject><subject>Chemotaxis</subject><subject>Cyclic AMP</subject><subject>Escherichia coli - immunology</subject><subject>Hot Temperature</subject><subject>Macrophage Migration-Inhibitory Factors - pharmacology</subject><subject>Rabbits</subject><subject>Toxins, Biological - pharmacology</subject><issn>0360-3997</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNot0D1PwzAYBGAPoFIKCzuSJ7YUfzseoWoBqRISH3Nkx29aoyQOdiLRf08RnW55dNIdQjeULCkh-v5xQ4ihRGtzhuaEK1JwY_QFusz5ixBSmpLP0EwxxRjXc_T2Pg1DgpxD7HFscLLOhREPkMIYe7At7myd4rC3O8Bd2CU7_kl3wHuwY9FaF1rA6yWuYxvwGH9Cf4XOG9tmuD7lAn1u1h-r52L7-vSyetgWA2V0LIxyWgmtpdSEuwZKCopy4KKRgjJeW8pAeC5AKAbMl5xLr0ohvWuM997yBbr77x1S_J4gj1UXcg1ta3uIU660VEweRx7h7QlOrgNfDSl0Nh2q0wn8F3LTWz4</recordid><startdate>198103</startdate><enddate>198103</enddate><creator>Cushing, A H</creator><creator>Murphy, S</creator><creator>Skipper, B E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198103</creationdate><title>Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin</title><author>Cushing, A H ; Murphy, S ; Skipper, B E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p121t-96b7647755703bfe81e613e34f54123ca12e4d34e462e2d8335d6845dbf9ddda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Ascitic Fluid - cytology</topic><topic>Chemotaxis</topic><topic>Cyclic AMP</topic><topic>Escherichia coli - immunology</topic><topic>Hot Temperature</topic><topic>Macrophage Migration-Inhibitory Factors - pharmacology</topic><topic>Rabbits</topic><topic>Toxins, Biological - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cushing, A H</creatorcontrib><creatorcontrib>Murphy, S</creatorcontrib><creatorcontrib>Skipper, B E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cushing, A H</au><au>Murphy, S</au><au>Skipper, B E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin</atitle><jtitle>Inflammation</jtitle><addtitle>Inflammation</addtitle><date>1981-03</date><risdate>1981</risdate><volume>5</volume><issue>1</issue><spage>55</spage><epage>60</epage><pages>55-60</pages><issn>0360-3997</issn><abstract>Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested.</abstract><cop>United States</cop><pmid>6262237</pmid><doi>10.1007/BF00910779</doi><tpages>6</tpages></addata></record> |
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subjects | Animals Ascitic Fluid - cytology Chemotaxis Cyclic AMP Escherichia coli - immunology Hot Temperature Macrophage Migration-Inhibitory Factors - pharmacology Rabbits Toxins, Biological - pharmacology |
title | Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin |
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