Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin

Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated...

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Veröffentlicht in:Inflammation 1981-03, Vol.5 (1), p.55-60
Hauptverfasser: Cushing, A H, Murphy, S, Skipper, B E
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creator Cushing, A H
Murphy, S
Skipper, B E
description Migration of rabbit peritoneal macrophages toward casein-serum was inhibited by preincubation of the cells with heat-labile toxin of Escherichia coli in direct relationship to the concentration of toxin in the incubation mixture. Cells preincubated with heated toxin or with toxin-antiserum migrated the same as those which had been incubated in toxin-free media. Toxin-preincubated cells had levels of cyclic AMP which were increased in direct relationship to the concentration of toxin in the preincubation mixture. Heated toxin failed to induce increased levels of cAMP in the cells at the highest concentration tested.
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source MEDLINE; Springer Online Journals
subjects Animals
Ascitic Fluid - cytology
Chemotaxis
Cyclic AMP
Escherichia coli - immunology
Hot Temperature
Macrophage Migration-Inhibitory Factors - pharmacology
Rabbits
Toxins, Biological - pharmacology
title Suppression of rabbit peritoneal macrophage migration by heat-labile E. coli toxin
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