Evidence that endogenous generation of leukotrienes does not regulate proliferation of malignant hemopoietic cell lines

The proliferation of malignant hemopoietic cell lines is inhibited by antagonists of 5-lipoxygenase, suggesting that the endogenous generation of leukotrienes via the action of this enzyme may play some role in the proliferation of these cells (Snyder D. S., Castro R. & Desforges J. F. (1989), E...

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Veröffentlicht in:	Leukemia research 1993-03, Vol.17 (3), p.241-245
Hauptverfasser:	Ayyub Khan, M., Tateson, James E., Hoffbrand, A.Victor, Wickremasinghe, R.Gitendra
Format:	Artikel
Sprache:	eng
Schlagworte:	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine - pharmacology Antineoplastic agents Benzeneacetamides Biological and medical sciences Blast Crisis Burkitt Lymphoma - drug therapy Burkitt Lymphoma - enzymology Burkitt Lymphoma - pathology Cell Division - drug effects Cell Division - physiology cell proliferation Epoprostenol - analogs & derivatives Epoprostenol - pharmacology General aspects Hematopoietic System - cytology Hematopoietic System - metabolism Hematopoietic System - physiology Humans Hydroxamic Acids - pharmacology Indoles - pharmacology Leukemia - drug therapy Leukemia - metabolism Leukemia - pathology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - enzymology Leukemia, Promyelocytic, Acute - pathology Leukemia-Lymphoma, Adult T-Cell - drug therapy Leukemia-Lymphoma, Adult T-Cell - enzymology Leukemia-Lymphoma, Adult T-Cell - pathology Leukotriene Antagonists Leukotrienes Leukotrienes - biosynthesis Leukotrienes - physiology lipoxygenase Lipoxygenase Inhibitors - pharmacology Masoprocol - pharmacology Medical sciences Pharmacology. Drug treatments Tumor Cells, Cultured
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