Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is usually associated with the translocation t(15;17)(q22;q12‐21), which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a patient with typical APL without the common t(15;17). Cytogenetic studies...

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Veröffentlicht in:	Genes chromosomes & cancer 1993-02, Vol.6 (2), p.118-120
Hauptverfasser:	Baranger, L., Gardembas, M., Hillion, J., Foussard, C., Ifrah, N., Boasson, M., Berger, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute promyeloid leukemia Adult Bone Marrow Transplantation Carrier Proteins - genetics chromosomes Chromosomes, Human, Pair 15 - ultrastructure Chromosomes, Human, Pair 17 - ultrastructure Female Gene Rearrangement genes Humans Karyotyping Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - surgery Male man PML gene RARA gene rearrangement Receptors, Retinoic Acid Translocation, Genetic
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