Iron deficiency in one-year-old infants: Comparison of results of a therapeutic trial in infants with anemia or low-normal hemoglobin values
The purpose of this study was to determine the Hgb response to a therapeutic trial of iron in infants with anemia compared to those with low-normal hemoglobin values. Hgb was determined in 1,128 one-year-old infants. The 278 infants (25%) who had an Hgb
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| Veröffentlicht in: | The Journal of pediatrics 1981-05, Vol.98 (5), p.753-758 |
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| container_title | The Journal of pediatrics |
| container_volume | 98 |
| creator | Driggers, David A. Reeves, Jerry D. Lo, Edward Y.T. Dallman, Peter R. |
| description | The purpose of this study was to determine the Hgb response to a therapeutic trial of iron in infants with anemia compared to those with low-normal hemoglobin values. Hgb was determined in 1,128 one-year-old infants. The 278 infants (25%) who had an Hgb |
| doi_str_mv | 10.1016/S0022-3476(81)80836-0 |
| format | Article |
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anemic range (Hgb <11.0 gm/dl), 45% had an increase in venous Hgb ≥1.0 gm/dl. Of the 113 infants with initial capillary values in the
lownormal range (11.0 to 11.4 gm/dl), 28% had a ≥1.0 gm/dl Hgb response. Despite the lower rate of response in the low-normal group, almost half of the infants with a ≥1 gm/dl response would have been missed by using the generally accepted cutoff value of 11 gm/dl for a therapeutic trial. Because of the low cost and simplicity of a therapeutic trial, we favor including the low-normal Hgb group for a therapeutic trial of iron in order to avold missing iron-responsive individuals among groups of infants with a similarly high prevalence of iron deficiency anemia.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(81)80836-0</identifier><identifier>PMID: 7229753</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adult ; Anemia, Hypochromic - drug therapy ; Evaluation Studies as Topic ; Female ; Ferrous Compounds - therapeutic use ; Hemoglobins - analysis ; Humans ; Infant ; Iron - therapeutic use ; Male ; Mass Screening ; Reference Values</subject><ispartof>The Journal of pediatrics, 1981-05, Vol.98 (5), p.753-758</ispartof><rights>1981 The C. V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-647cea92ef48cca40e566b1ffa0778bee71cb3881725b54f0560516056d43a2a3</citedby><cites>FETCH-LOGICAL-c360t-647cea92ef48cca40e566b1ffa0778bee71cb3881725b54f0560516056d43a2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(81)80836-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7229753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Driggers, David A.</creatorcontrib><creatorcontrib>Reeves, Jerry D.</creatorcontrib><creatorcontrib>Lo, Edward Y.T.</creatorcontrib><creatorcontrib>Dallman, Peter R.</creatorcontrib><title>Iron deficiency in one-year-old infants: Comparison of results of a therapeutic trial in infants with anemia or low-normal hemoglobin values</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>The purpose of this study was to determine the Hgb response to a therapeutic trial of iron in infants with anemia compared to those with low-normal hemoglobin values. Hgb was determined in 1,128 one-year-old infants. The 278 infants (25%) who had an Hgb <11.5 gm/dl were given a three-month oral course of ferrous sulfate (3 mg iron/kg/day); the regimen was satisfactorily completed by 188 infants. Of the 75 infants whose initial capillary Hgb was in the
anemic range (Hgb <11.0 gm/dl), 45% had an increase in venous Hgb ≥1.0 gm/dl. Of the 113 infants with initial capillary values in the
lownormal range (11.0 to 11.4 gm/dl), 28% had a ≥1.0 gm/dl Hgb response. Despite the lower rate of response in the low-normal group, almost half of the infants with a ≥1 gm/dl response would have been missed by using the generally accepted cutoff value of 11 gm/dl for a therapeutic trial. Because of the low cost and simplicity of a therapeutic trial, we favor including the low-normal Hgb group for a therapeutic trial of iron in order to avold missing iron-responsive individuals among groups of infants with a similarly high prevalence of iron deficiency anemia.</description><subject>Adult</subject><subject>Anemia, Hypochromic - drug therapy</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Ferrous Compounds - therapeutic use</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Infant</subject><subject>Iron - therapeutic use</subject><subject>Male</subject><subject>Mass Screening</subject><subject>Reference Values</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhYnRjO3oI0zCyugCvUAV0G7MpKMzk0ziQl0TirplY6qKFqiZ9Dv40NI_ma0LAuR-9x44h5ArDh84cPXxO4AQTDZavTP8vQEjFYNnZMVhrZkyUj4nqyfkJXmV828AWDcAF-RCC7HWrVyRv3cpzrTHIfiAs9_TMNM4I9ujSyyOfb0Pbi75E93EaedSyBWPA02Yl7Hkw9HRssXkdriU4GlJwY2HKedG-hjKlroZp-BoTHSMj2yOaarQFqf4a4xdhR_cuGB-TV4Mbsz45rxfkp9fv_zY3LL7bzd3m-t75qWCwlSjPbq1wKEx3rsGsFWq48PgQGvTIWruO2kM16Lt2maAVkHL61J9I51w8pK8Pc3dpfin6hY7hexxHOsz45KtbpUQQvEKtifQp5hzwsHuUphc2lsO9pCCPaZgDxZbw-0xBQu17-ossHQT9k9dZ9tr_fOpjvWXDwGTzUf7sQ8JfbF9DP9R-AekpZka</recordid><startdate>198105</startdate><enddate>198105</enddate><creator>Driggers, David A.</creator><creator>Reeves, Jerry D.</creator><creator>Lo, Edward Y.T.</creator><creator>Dallman, Peter R.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198105</creationdate><title>Iron deficiency in one-year-old infants: Comparison of results of a therapeutic trial in infants with anemia or low-normal hemoglobin values</title><author>Driggers, David A. ; Reeves, Jerry D. ; Lo, Edward Y.T. ; Dallman, Peter R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-647cea92ef48cca40e566b1ffa0778bee71cb3881725b54f0560516056d43a2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Adult</topic><topic>Anemia, Hypochromic - drug therapy</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Ferrous Compounds - therapeutic use</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Infant</topic><topic>Iron - therapeutic use</topic><topic>Male</topic><topic>Mass Screening</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Driggers, David A.</creatorcontrib><creatorcontrib>Reeves, Jerry D.</creatorcontrib><creatorcontrib>Lo, Edward Y.T.</creatorcontrib><creatorcontrib>Dallman, Peter R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Driggers, David A.</au><au>Reeves, Jerry D.</au><au>Lo, Edward Y.T.</au><au>Dallman, Peter R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron deficiency in one-year-old infants: Comparison of results of a therapeutic trial in infants with anemia or low-normal hemoglobin values</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1981-05</date><risdate>1981</risdate><volume>98</volume><issue>5</issue><spage>753</spage><epage>758</epage><pages>753-758</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>The purpose of this study was to determine the Hgb response to a therapeutic trial of iron in infants with anemia compared to those with low-normal hemoglobin values. Hgb was determined in 1,128 one-year-old infants. The 278 infants (25%) who had an Hgb <11.5 gm/dl were given a three-month oral course of ferrous sulfate (3 mg iron/kg/day); the regimen was satisfactorily completed by 188 infants. Of the 75 infants whose initial capillary Hgb was in the
anemic range (Hgb <11.0 gm/dl), 45% had an increase in venous Hgb ≥1.0 gm/dl. Of the 113 infants with initial capillary values in the
lownormal range (11.0 to 11.4 gm/dl), 28% had a ≥1.0 gm/dl Hgb response. Despite the lower rate of response in the low-normal group, almost half of the infants with a ≥1 gm/dl response would have been missed by using the generally accepted cutoff value of 11 gm/dl for a therapeutic trial. Because of the low cost and simplicity of a therapeutic trial, we favor including the low-normal Hgb group for a therapeutic trial of iron in order to avold missing iron-responsive individuals among groups of infants with a similarly high prevalence of iron deficiency anemia.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>7229753</pmid><doi>10.1016/S0022-3476(81)80836-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1981-05, Vol.98 (5), p.753-758 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Anemia, Hypochromic - drug therapy Evaluation Studies as Topic Female Ferrous Compounds - therapeutic use Hemoglobins - analysis Humans Infant Iron - therapeutic use Male Mass Screening Reference Values |
| title | Iron deficiency in one-year-old infants: Comparison of results of a therapeutic trial in infants with anemia or low-normal hemoglobin values |
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