Relation between patent foramen ovale and unexplained stroke
To better elucidate the possible role of the patent foramen ovale (PFO) in patients with unexplained stroke, the relation between the incidence of stroke and 3 characteristics of PFO (timing, magnitude of appearance of echocardiographic contrast in the left atrium, and morphology of the atrial septu...
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| Veröffentlicht in: | The American journal of cardiology 1993-03, Vol.71 (7), p.596-598 |
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| creator | Van Camp, Guy Schulze, Dominique Cosyns, Bernard Vandenbossche, Jean-Luc |
| description | To better elucidate the possible role of the patent foramen ovale (PFO) in patients with unexplained stroke, the relation between the incidence of stroke and 3 characteristics of PFO (timing, magnitude of appearance of echocardiographic contrast in the left atrium, and morphology of the atrial septum) was analyzed. Twentynine patients with unexplained stroke and 28 without stroke were compared. A significant relation was only found between the incidence of cerebrovascular accident and positive contrast echocardiography in patients with early and massive passage of contrast in the left atrium (6 of 29 [21%] in the stroke group vs 0 of 28 [0%] in the control group; p < 0.05). An abnormal morphology of the foramen ovale was found more frequently in patients with PFO than in those without PFO (9 of 13 [69%] vs 1 of 44 [2%]; p < 0.001).
The results suggest the use of timing and quantification of contrast appearance in the left atrium during contrast transesophageal echocardiography, and that paradoxical embolism through a PFO is a possible mechanism of cryptogenic stroke only if there is a massive passage of contrast through an abnormal foramen ovale. |
| doi_str_mv | 10.1016/0002-9149(93)90518-H |
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The results suggest the use of timing and quantification of contrast appearance in the left atrium during contrast transesophageal echocardiography, and that paradoxical embolism through a PFO is a possible mechanism of cryptogenic stroke only if there is a massive passage of contrast through an abnormal foramen ovale.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(93)90518-H</identifier><identifier>PMID: 8438748</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Biological and medical sciences ; Cardiovascular disease ; Cough - physiopathology ; Echocardiography ; Female ; Heart Septal Defects, Atrial - complications ; Heart Septal Defects, Atrial - diagnostic imaging ; Humans ; Intracranial Embolism and Thrombosis - etiology ; Male ; Medical research ; Medical sciences ; Middle Aged ; Neurology ; Stroke ; Valsalva Maneuver ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>The American journal of cardiology, 1993-03, Vol.71 (7), p.596-598</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Mar 1, 1993</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-6bc4ad493a921e9a59a9db8d7a069423c50607416312cb267ab4b53281aad3293</citedby><cites>FETCH-LOGICAL-c413t-6bc4ad493a921e9a59a9db8d7a069423c50607416312cb267ab4b53281aad3293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000291499390518H$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4629689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8438748$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Camp, Guy</creatorcontrib><creatorcontrib>Schulze, Dominique</creatorcontrib><creatorcontrib>Cosyns, Bernard</creatorcontrib><creatorcontrib>Vandenbossche, Jean-Luc</creatorcontrib><title>Relation between patent foramen ovale and unexplained stroke</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>To better elucidate the possible role of the patent foramen ovale (PFO) in patients with unexplained stroke, the relation between the incidence of stroke and 3 characteristics of PFO (timing, magnitude of appearance of echocardiographic contrast in the left atrium, and morphology of the atrial septum) was analyzed. Twentynine patients with unexplained stroke and 28 without stroke were compared. A significant relation was only found between the incidence of cerebrovascular accident and positive contrast echocardiography in patients with early and massive passage of contrast in the left atrium (6 of 29 [21%] in the stroke group vs 0 of 28 [0%] in the control group; p < 0.05). An abnormal morphology of the foramen ovale was found more frequently in patients with PFO than in those without PFO (9 of 13 [69%] vs 1 of 44 [2%]; p < 0.001).
The results suggest the use of timing and quantification of contrast appearance in the left atrium during contrast transesophageal echocardiography, and that paradoxical embolism through a PFO is a possible mechanism of cryptogenic stroke only if there is a massive passage of contrast through an abnormal foramen ovale.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Cough - physiopathology</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Heart Septal Defects, Atrial - complications</subject><subject>Heart Septal Defects, Atrial - diagnostic imaging</subject><subject>Humans</subject><subject>Intracranial Embolism and Thrombosis - etiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Stroke</subject><subject>Valsalva Maneuver</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGKFDEQhoMo67j6BgqNiOihNZWk0wnIwrKos7AgiJ5DdVIDWXuSMele17e3xxnm4MFT8VNfFVUfY8-BvwMO-j3nXLQWlH1j5VvLOzDt-gFbgeltCxbkQ7Y6IY_Zk1pvlwjQ6TN2ZpQ0vTIr9uErjTjFnJqBpl9EqdnhRGlqNrngdon5DkdqMIVmTnS_GzEmCk2dSv5BT9mjDY6Vnh3rOfv-6eO3q3V78-Xz9dXlTesVyKnVg1cYlJVoBZDFzqINgwk9cm2VkL7jmvcKtAThB6F7HNTQSWEAMUhh5Tl7fdi7K_nnTHVy21g9jSMmynN1facF74VewJf_gLd5Lmm5zQnJpVIGzAKpA-RLrrXQxu1K3GL57YC7vVm31-b22pyV7q9Zt17GXhx3z8OWwmnoqHLpvzr2sXocNwWTj_WEKS2sNvtfLg4YLcLuIhVXfaTkKcRCfnIhx__f8QfhzZKs</recordid><startdate>19930301</startdate><enddate>19930301</enddate><creator>Van Camp, Guy</creator><creator>Schulze, Dominique</creator><creator>Cosyns, Bernard</creator><creator>Vandenbossche, Jean-Luc</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19930301</creationdate><title>Relation between patent foramen ovale and unexplained stroke</title><author>Van Camp, Guy ; Schulze, Dominique ; Cosyns, Bernard ; Vandenbossche, Jean-Luc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-6bc4ad493a921e9a59a9db8d7a069423c50607416312cb267ab4b53281aad3293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Cough - physiopathology</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Heart Septal Defects, Atrial - complications</topic><topic>Heart Septal Defects, Atrial - diagnostic imaging</topic><topic>Humans</topic><topic>Intracranial Embolism and Thrombosis - etiology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Stroke</topic><topic>Valsalva Maneuver</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Camp, Guy</creatorcontrib><creatorcontrib>Schulze, Dominique</creatorcontrib><creatorcontrib>Cosyns, Bernard</creatorcontrib><creatorcontrib>Vandenbossche, Jean-Luc</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Camp, Guy</au><au>Schulze, Dominique</au><au>Cosyns, Bernard</au><au>Vandenbossche, Jean-Luc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation between patent foramen ovale and unexplained stroke</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1993-03-01</date><risdate>1993</risdate><volume>71</volume><issue>7</issue><spage>596</spage><epage>598</epage><pages>596-598</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>To better elucidate the possible role of the patent foramen ovale (PFO) in patients with unexplained stroke, the relation between the incidence of stroke and 3 characteristics of PFO (timing, magnitude of appearance of echocardiographic contrast in the left atrium, and morphology of the atrial septum) was analyzed. Twentynine patients with unexplained stroke and 28 without stroke were compared. A significant relation was only found between the incidence of cerebrovascular accident and positive contrast echocardiography in patients with early and massive passage of contrast in the left atrium (6 of 29 [21%] in the stroke group vs 0 of 28 [0%] in the control group; p < 0.05). An abnormal morphology of the foramen ovale was found more frequently in patients with PFO than in those without PFO (9 of 13 [69%] vs 1 of 44 [2%]; p < 0.001).
The results suggest the use of timing and quantification of contrast appearance in the left atrium during contrast transesophageal echocardiography, and that paradoxical embolism through a PFO is a possible mechanism of cryptogenic stroke only if there is a massive passage of contrast through an abnormal foramen ovale.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8438748</pmid><doi>10.1016/0002-9149(93)90518-H</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Aged Biological and medical sciences Cardiovascular disease Cough - physiopathology Echocardiography Female Heart Septal Defects, Atrial - complications Heart Septal Defects, Atrial - diagnostic imaging Humans Intracranial Embolism and Thrombosis - etiology Male Medical research Medical sciences Middle Aged Neurology Stroke Valsalva Maneuver Vascular diseases and vascular malformations of the nervous system |
| title | Relation between patent foramen ovale and unexplained stroke |
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