Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients
Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the...
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| Veröffentlicht in: | American journal of hematology 1993-03, Vol.42 (3), p.316-321 |
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| creator | Adekile, A. D. McKie, K. M. Adeodu, O. O. Sulzer, A. J. Liu, J.‐S. McKie, V. C. Kutlar, F. Ramachandran, M. Kaine, W. Akenzua, G. I. Okolo, A. A. Asindi, A. A. Obinyan, E. A. Ogala, W. N. Ibrahim, M. Huisman, T. H. J. |
| description | Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age‐ and sex‐matched Nigerian and U.S. steady‐state SS patients were compared. Splenomegaly was found in 22.3% of Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean ± SE of IgG‐specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 ± 2,036; 9,334 ± 2,980 in those with spleens between 1 and 5 cm, 16,201 ± 4,502 in those with spleens between 6 and 10 cm, and 22,445 ± 8,456 in those with spleens above 10 cm. Coexistent α‐thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. © 1993 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/ajh.2830420313 |
| format | Article |
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D. ; McKie, K. M. ; Adeodu, O. O. ; Sulzer, A. J. ; Liu, J.‐S. ; McKie, V. C. ; Kutlar, F. ; Ramachandran, M. ; Kaine, W. ; Akenzua, G. I. ; Okolo, A. A. ; Asindi, A. A. ; Obinyan, E. A. ; Ogala, W. N. ; Ibrahim, M. ; Huisman, T. H. J.</creator><creatorcontrib>Adekile, A. D. ; McKie, K. M. ; Adeodu, O. O. ; Sulzer, A. J. ; Liu, J.‐S. ; McKie, V. C. ; Kutlar, F. ; Ramachandran, M. ; Kaine, W. ; Akenzua, G. I. ; Okolo, A. A. ; Asindi, A. A. ; Obinyan, E. A. ; Ogala, W. N. ; Ibrahim, M. ; Huisman, T. H. J.</creatorcontrib><description>Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age‐ and sex‐matched Nigerian and U.S. steady‐state SS patients were compared. Splenomegaly was found in 22.3% of Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean ± SE of IgG‐specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 ± 2,036; 9,334 ± 2,980 in those with spleens between 1 and 5 cm, 16,201 ± 4,502 in those with spleens between 6 and 10 cm, and 22,445 ± 8,456 in those with spleens above 10 cm. Coexistent α‐thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. © 1993 Wiley‐Liss, Inc.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.2830420313</identifier><identifier>PMID: 8438905</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; African SS patients ; alpha-Thalassemia - genetics ; Anemia, Sickle Cell - epidemiology ; Anemias. Hemoglobinopathies ; Antibodies, Protozoan - blood ; Biological and medical sciences ; Child ; Child, Preschool ; Chromosome Mapping ; Complement System Proteins - analysis ; Diseases of red blood cells ; Erythrocyte Count ; Female ; Georgia - epidemiology ; Globins - genetics ; Hematologic and hematopoietic diseases ; Humans ; Immunoglobulins - blood ; Infant ; malaria ; Malaria - immunology ; Male ; Medical sciences ; Nigeria - epidemiology ; splenomegaly ; Splenomegaly - epidemiology</subject><ispartof>American journal of hematology, 1993-03, Vol.42 (3), p.316-321</ispartof><rights>Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2843-b224996944312b6d471b6387f7dcdce458c5a0bc970a9d535588fe7fd6fedfc33</citedby><cites>FETCH-LOGICAL-c2843-b224996944312b6d471b6387f7dcdce458c5a0bc970a9d535588fe7fd6fedfc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajh.2830420313$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajh.2830420313$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4625953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8438905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adekile, A. D.</creatorcontrib><creatorcontrib>McKie, K. M.</creatorcontrib><creatorcontrib>Adeodu, O. O.</creatorcontrib><creatorcontrib>Sulzer, A. J.</creatorcontrib><creatorcontrib>Liu, J.‐S.</creatorcontrib><creatorcontrib>McKie, V. C.</creatorcontrib><creatorcontrib>Kutlar, F.</creatorcontrib><creatorcontrib>Ramachandran, M.</creatorcontrib><creatorcontrib>Kaine, W.</creatorcontrib><creatorcontrib>Akenzua, G. I.</creatorcontrib><creatorcontrib>Okolo, A. A.</creatorcontrib><creatorcontrib>Asindi, A. A.</creatorcontrib><creatorcontrib>Obinyan, E. A.</creatorcontrib><creatorcontrib>Ogala, W. N.</creatorcontrib><creatorcontrib>Ibrahim, M.</creatorcontrib><creatorcontrib>Huisman, T. H. J.</creatorcontrib><title>Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients</title><title>American journal of hematology</title><addtitle>Am J Hematol</addtitle><description>Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age‐ and sex‐matched Nigerian and U.S. steady‐state SS patients were compared. Splenomegaly was found in 22.3% of Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean ± SE of IgG‐specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 ± 2,036; 9,334 ± 2,980 in those with spleens between 1 and 5 cm, 16,201 ± 4,502 in those with spleens between 6 and 10 cm, and 22,445 ± 8,456 in those with spleens above 10 cm. Coexistent α‐thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. © 1993 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>African SS patients</subject><subject>alpha-Thalassemia - genetics</subject><subject>Anemia, Sickle Cell - epidemiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Antibodies, Protozoan - blood</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosome Mapping</subject><subject>Complement System Proteins - analysis</subject><subject>Diseases of red blood cells</subject><subject>Erythrocyte Count</subject><subject>Female</subject><subject>Georgia - epidemiology</subject><subject>Globins - genetics</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoglobulins - blood</subject><subject>Infant</subject><subject>malaria</subject><subject>Malaria - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nigeria - epidemiology</subject><subject>splenomegaly</subject><subject>Splenomegaly - epidemiology</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtvGzEQhAnDhiM_2nQBWBjpdOH7SHeCkNgxBKuQVR945DKhcy8fpRj696EgwXaXahfYb2cGg9BnSgpKCPtmn38XTHMiGOGUn6AJJUZNtZLsFE0IVzTvxHxCFyk9E0Kp0OQcnWvBtSFygparoQHocOxwiu5PA9hB02DbQRvtLZ737WBHu4l_AafN1kdIuA_4Mf6CMdoucx6vi1WBh8xAt0lX6CzYJsH1cV6i9Y_vT_P76WJ593M-W0wdy97TmjFhjDJCcMpq5UVJa8V1GUrvvAMhtZOW1M6UxBovuZRaByiDVwF8cJxfoq8H3WHsX7aQNlUb0z56Tt5vU1VKRQ0nZQaLA-jGPqURQjWMsbXjrqKk2jdY5Qar9wbzw5ej8rZuwb_hx8ry_eZ4t8nZJoy2czG9YUIxaeRexhyw19jA7j-m1ezh_kOEf8BOiDU</recordid><startdate>199303</startdate><enddate>199303</enddate><creator>Adekile, A. D.</creator><creator>McKie, K. M.</creator><creator>Adeodu, O. O.</creator><creator>Sulzer, A. J.</creator><creator>Liu, J.‐S.</creator><creator>McKie, V. C.</creator><creator>Kutlar, F.</creator><creator>Ramachandran, M.</creator><creator>Kaine, W.</creator><creator>Akenzua, G. I.</creator><creator>Okolo, A. A.</creator><creator>Asindi, A. A.</creator><creator>Obinyan, E. A.</creator><creator>Ogala, W. N.</creator><creator>Ibrahim, M.</creator><creator>Huisman, T. H. J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199303</creationdate><title>Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients</title><author>Adekile, A. D. ; McKie, K. M. ; Adeodu, O. O. ; Sulzer, A. J. ; Liu, J.‐S. ; McKie, V. C. ; Kutlar, F. ; Ramachandran, M. ; Kaine, W. ; Akenzua, G. I. ; Okolo, A. A. ; Asindi, A. A. ; Obinyan, E. A. ; Ogala, W. N. ; Ibrahim, M. ; Huisman, T. H. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2843-b224996944312b6d471b6387f7dcdce458c5a0bc970a9d535588fe7fd6fedfc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>African SS patients</topic><topic>alpha-Thalassemia - genetics</topic><topic>Anemia, Sickle Cell - epidemiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Antibodies, Protozoan - blood</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosome Mapping</topic><topic>Complement System Proteins - analysis</topic><topic>Diseases of red blood cells</topic><topic>Erythrocyte Count</topic><topic>Female</topic><topic>Georgia - epidemiology</topic><topic>Globins - genetics</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoglobulins - blood</topic><topic>Infant</topic><topic>malaria</topic><topic>Malaria - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nigeria - epidemiology</topic><topic>splenomegaly</topic><topic>Splenomegaly - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adekile, A. D.</creatorcontrib><creatorcontrib>McKie, K. M.</creatorcontrib><creatorcontrib>Adeodu, O. O.</creatorcontrib><creatorcontrib>Sulzer, A. 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J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adekile, A. D.</au><au>McKie, K. M.</au><au>Adeodu, O. O.</au><au>Sulzer, A. J.</au><au>Liu, J.‐S.</au><au>McKie, V. C.</au><au>Kutlar, F.</au><au>Ramachandran, M.</au><au>Kaine, W.</au><au>Akenzua, G. I.</au><au>Okolo, A. A.</au><au>Asindi, A. A.</au><au>Obinyan, E. A.</au><au>Ogala, W. N.</au><au>Ibrahim, M.</au><au>Huisman, T. H. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1993-03</date><risdate>1993</risdate><volume>42</volume><issue>3</issue><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Anecdotal reports have attributed persistent splenomegaly in African sickle cell anemia (SS) patients to the effects of malaria. However, no comparative studies of patients in malarial and nonmalarial regions have been conducted, and few studies of malaria antibody titers have been reported. In the present study, age‐ and sex‐matched Nigerian and U.S. steady‐state SS patients were compared. Splenomegaly was found in 22.3% of Nigerian patients (n = 310), while it was found only in 8% of U.S. patients (n = 100) from Georgia. There was significant linear correlation between spleen size and Hb levels and with serum immunoglobulins in the Nigerian group. However, serum complement levels (C3 and C4) were not affected by spleen size. In both groups, patients with splenomegaly had fewer circulating pitted red cells than their counterparts without splenomegaly. The mean ± SE of IgG‐specific malaria antibody titer among the Nigerian patients without palpable spleens was 9,386 ± 2,036; 9,334 ± 2,980 in those with spleens between 1 and 5 cm, 16,201 ± 4,502 in those with spleens between 6 and 10 cm, and 22,445 ± 8,456 in those with spleens above 10 cm. Coexistent α‐thalassemia did not influence the prevalence of splenomegaly among the Nigerian SS patients. This study provides additional evidence that malaria plays a significant role in the persistence of splenomegaly in African patients. © 1993 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8438905</pmid><doi>10.1002/ajh.2830420313</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult African SS patients alpha-Thalassemia - genetics Anemia, Sickle Cell - epidemiology Anemias. Hemoglobinopathies Antibodies, Protozoan - blood Biological and medical sciences Child Child, Preschool Chromosome Mapping Complement System Proteins - analysis Diseases of red blood cells Erythrocyte Count Female Georgia - epidemiology Globins - genetics Hematologic and hematopoietic diseases Humans Immunoglobulins - blood Infant malaria Malaria - immunology Male Medical sciences Nigeria - epidemiology splenomegaly Splenomegaly - epidemiology |
| title | Spleen in sickle cell anemia: Comparative studies of Nigerian and U.S. patients |
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