Studies on cerebral protective agents. IV: Synthesis of novel 4-arylpyridine and 4-arylpyridazine derivatives with anti-anoxic activity
In a search for new cerebral protective agents, a series of 4-(3- or 4-nitrophenyl)-6-phenylpyridines (or pyridazines) and 2-(3-nitrophenyl)-6-phenylpyridines, possessing an amino moiety at the C-3 position of the pyridine (or pyridazine) ring, were synthesized through the corresponding novel 1,4-di...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1993, Vol.41 (1), p.156-162 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | KUNO, A SAKAI, H SUGIYAMA, Y TAKASUGI, H |
| description | In a search for new cerebral protective agents, a series of 4-(3- or 4-nitrophenyl)-6-phenylpyridines (or pyridazines) and 2-(3-nitrophenyl)-6-phenylpyridines, possessing an amino moiety at the C-3 position of the pyridine (or pyridazine) ring, were synthesized through the corresponding novel 1,4-dihydro derivatives and tested for anti-anoxic (AA) activity in mice. Four compounds (2c, 2f, 3a, 4a) possessed significant AA activity at a dose of 32 mg/kg, i.p. These results suggest that four-atom linkages between the C-3 position of the pyridine (or pyridazine) ring and the nitrogenous basic moiety also seems to be a prerequisite for the expression of AA activity. |
| doi_str_mv | 10.1248/cpb.41.156 |
| format | Article |
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These results suggest that four-atom linkages between the C-3 position of the pyridine (or pyridazine) ring and the nitrogenous basic moiety also seems to be a prerequisite for the expression of AA activity.</description><subject>Animals</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Heterocyclic compounds</subject><subject>Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings</subject><subject>Hypoxia, Brain - prevention & control</subject><subject>Mice</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>Pyridazines - chemical synthesis</subject><subject>Pyridazines - pharmacology</subject><subject>Pyridines - chemical synthesis</subject><subject>Pyridines - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLJDEUhYOMaPvYuBeyGFwI1eadKneD-ALBhY9tkUpujRmqU22S7rH9A_5t09iIqwvnfJzLOQgdUTKlTNRndt5NBZ1SqbbQhHKhK8kY_4UmhJCmYlzxXbSX0j9CmCSa76CdWoi6pmqCPh7ywnlIeAzYQoQumgHP45jBZr8EbP5CyGmKb5_P8cMq5BdIvsA9DuMSBiwqE1fDfBW986HQwf2UzPtadBD90qzTEv7v80uhsq9MGN-8xWb9xufVAdruzZDgcHP30dPV5ePFTXV3f3178eeuspzVqqK8k0o7J6zUHWucM8Rq0kvHHZG9bKxwjoPWzDFVg1Sddj3jFHopZCec4vvo5Cu3dHxdQMrtzCcLw2ACjIvUaqloQ5Qu4OkXaOOYUoS-nUc_K9VaStr16m1ZvRW0LasX-HiTuuhm4L7RzczF_73xTbJm6KMJ1qdvTGgmG8L4J0q1jLk</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>KUNO, A</creator><creator>SAKAI, H</creator><creator>SUGIYAMA, Y</creator><creator>TAKASUGI, H</creator><general>Maruzen</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Studies on cerebral protective agents. 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IV: Synthesis of novel 4-arylpyridine and 4-arylpyridazine derivatives with anti-anoxic activity</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem Pharm Bull (Tokyo)</addtitle><date>1993</date><risdate>1993</risdate><volume>41</volume><issue>1</issue><spage>156</spage><epage>162</epage><pages>156-162</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><coden>CPBTAL</coden><abstract>In a search for new cerebral protective agents, a series of 4-(3- or 4-nitrophenyl)-6-phenylpyridines (or pyridazines) and 2-(3-nitrophenyl)-6-phenylpyridines, possessing an amino moiety at the C-3 position of the pyridine (or pyridazine) ring, were synthesized through the corresponding novel 1,4-dihydro derivatives and tested for anti-anoxic (AA) activity in mice. Four compounds (2c, 2f, 3a, 4a) possessed significant AA activity at a dose of 32 mg/kg, i.p. 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| ispartof | Chemical & pharmaceutical bulletin, 1993, Vol.41 (1), p.156-162 |
| issn | 0009-2363 1347-5223 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Hypoxia, Brain - prevention & control Mice Organic chemistry Preparations and properties Pyridazines - chemical synthesis Pyridazines - pharmacology Pyridines - chemical synthesis Pyridines - pharmacology Structure-Activity Relationship |
| title | Studies on cerebral protective agents. IV: Synthesis of novel 4-arylpyridine and 4-arylpyridazine derivatives with anti-anoxic activity |
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